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Undifferentiated Lymphoma, Non-Burkitt's Type: Meningeal and Bone Marrow Involvement in Children

Undifferentiated Lymphoma, Non-Burkitt's Type: Meningeal and Bone Marrow Involvement in Children Abstract Among 30 children with undifferentiated lymphoma, non-Burkitt's type, bone marrow involvement occurred in 21 (70%). Ten of the 21 (48%) children with bone marrow change also developed meningeal involvement. None of the nine patients whose bone marrow remained normal showed meningeal change. Ten of 11 (91%) children with mediastinal presentations developed bone marrow involvement. None of the six children with small-bowel presentations developed bone marrow or meningeal involvement. Children with both bone marrow and meningeal involvement experienced significantly longer survival than children whose bone marrow remained normal (P=.01); these children also had a better median survival time than children developing bone marrow change without meningeal disease (10 months vs 3.5 months). Lymphomatous meningitis was not uniformly associated with advanced disease or with an immediately grave prognosis. References 1. Jones B, Klingberg WG: Lymphosarcoma in children: A report of 43 cases and review of the recent literature . J Pediatr 63:11-20, 1963.Crossref 2. Rosenberg SA, et al: Lymphosarcoma in childhood . N Engl J Med 259:505-512, 1958.Crossref 3. Jenkin RDT, Sonley MJ: The management of malignant lymphoma in childhood , in Neoplasia in Childhood: A Collection of Papers Presented at the Twelfth Annual Clinical Conference on Cancer, 1967 at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas . Chicago, Year Book Medical Publishers Inc, 1969, pp 305-319. 4. Bailey RJ, Burgert EO, Dahlin DC: Malignant lymphoma in children . Pediatrics 28:985-992, 1961. 5. Dargeon HW: Tumors of Childhood . New York, Paul B Hoeber, Inc, 1960, pp 329-357. 6. Pierce MI: Lymphosarcoma and Hodgkin's disease in children , in Proceedings of The Fourth National Cancer Conference . Philadelphia and Montreal, JB Lippincott, 1960, pp 559-570. 7. Sullivan MP: Leukemic transformation in lymphosarcoma of childhood . Pediatrics 29:589-599, 1962. 8. Jones B, et al: Chemotherapy of the leukemic transformation of lymphosarcoma . J Pediatr 70:442-448, 1967.Crossref 9. Aur RJA, et al: Therapy of localized and regional lymphosarcoma of childhood . Cancer 27:1328-1331, 1971.Crossref 10. Griffin JW, et al: Lymphomatous leptomeningitis . Am J Med 51:201-208, 1971.Crossref 11. Gendelman S, Rizzo F, Mones RJ: Central nervous system complications of leukemic conversion of the lymphomas . Cancer 24:676-682, 1969.Crossref 12. Rosenberg SA, et al: Lymphosarcoma: A review of 1269 cases . Medicine 40:31-84, 1961.Crossref 13. Shullenberger CC: Natural history patterns in leukemia and lymphoma as related to clinicopathologic classification, in Leukemia-Lymphoma: A Collection of Papers Presented at the Fourteenth Annual Clinical Conference on Cancer, 1969 at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas. Chicago, Year Book Medical Publishers Inc, 1970, pp 143-148. 14. Sullivan MP: Non-Hodgkin's lymphoma of childhood, in Sutow WW, Vietti TJ, Fernbach DJ (eds): Clinical Pediatric Oncology. St. Louis, CV Mosby Co Publishers, to be published. 15. Butler JJ: Histopathology of malignant lymphomas and Hodgkin's disease, in Leukemia-Lymphoma: A Collection of Papers Presented at the Fourteenth Annual Clinical Conference on Cancer, 1969 at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas. Chicago, Year Book Medical Publishers Inc, 1970, pp 123-142. 16. Verity GL: Neurologic manifestations and complications of lymphoma . Radiol Clin North Am 6:97-109, 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Undifferentiated Lymphoma, Non-Burkitt's Type: Meningeal and Bone Marrow Involvement in Children

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Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1973.04160010035008
Publisher site
See Article on Publisher Site

Abstract

Abstract Among 30 children with undifferentiated lymphoma, non-Burkitt's type, bone marrow involvement occurred in 21 (70%). Ten of the 21 (48%) children with bone marrow change also developed meningeal involvement. None of the nine patients whose bone marrow remained normal showed meningeal change. Ten of 11 (91%) children with mediastinal presentations developed bone marrow involvement. None of the six children with small-bowel presentations developed bone marrow or meningeal involvement. Children with both bone marrow and meningeal involvement experienced significantly longer survival than children whose bone marrow remained normal (P=.01); these children also had a better median survival time than children developing bone marrow change without meningeal disease (10 months vs 3.5 months). Lymphomatous meningitis was not uniformly associated with advanced disease or with an immediately grave prognosis. References 1. Jones B, Klingberg WG: Lymphosarcoma in children: A report of 43 cases and review of the recent literature . J Pediatr 63:11-20, 1963.Crossref 2. Rosenberg SA, et al: Lymphosarcoma in childhood . N Engl J Med 259:505-512, 1958.Crossref 3. Jenkin RDT, Sonley MJ: The management of malignant lymphoma in childhood , in Neoplasia in Childhood: A Collection of Papers Presented at the Twelfth Annual Clinical Conference on Cancer, 1967 at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas . Chicago, Year Book Medical Publishers Inc, 1969, pp 305-319. 4. Bailey RJ, Burgert EO, Dahlin DC: Malignant lymphoma in children . Pediatrics 28:985-992, 1961. 5. Dargeon HW: Tumors of Childhood . New York, Paul B Hoeber, Inc, 1960, pp 329-357. 6. Pierce MI: Lymphosarcoma and Hodgkin's disease in children , in Proceedings of The Fourth National Cancer Conference . Philadelphia and Montreal, JB Lippincott, 1960, pp 559-570. 7. Sullivan MP: Leukemic transformation in lymphosarcoma of childhood . Pediatrics 29:589-599, 1962. 8. Jones B, et al: Chemotherapy of the leukemic transformation of lymphosarcoma . J Pediatr 70:442-448, 1967.Crossref 9. Aur RJA, et al: Therapy of localized and regional lymphosarcoma of childhood . Cancer 27:1328-1331, 1971.Crossref 10. Griffin JW, et al: Lymphomatous leptomeningitis . Am J Med 51:201-208, 1971.Crossref 11. Gendelman S, Rizzo F, Mones RJ: Central nervous system complications of leukemic conversion of the lymphomas . Cancer 24:676-682, 1969.Crossref 12. Rosenberg SA, et al: Lymphosarcoma: A review of 1269 cases . Medicine 40:31-84, 1961.Crossref 13. Shullenberger CC: Natural history patterns in leukemia and lymphoma as related to clinicopathologic classification, in Leukemia-Lymphoma: A Collection of Papers Presented at the Fourteenth Annual Clinical Conference on Cancer, 1969 at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas. Chicago, Year Book Medical Publishers Inc, 1970, pp 143-148. 14. Sullivan MP: Non-Hodgkin's lymphoma of childhood, in Sutow WW, Vietti TJ, Fernbach DJ (eds): Clinical Pediatric Oncology. St. Louis, CV Mosby Co Publishers, to be published. 15. Butler JJ: Histopathology of malignant lymphomas and Hodgkin's disease, in Leukemia-Lymphoma: A Collection of Papers Presented at the Fourteenth Annual Clinical Conference on Cancer, 1969 at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas. Chicago, Year Book Medical Publishers Inc, 1970, pp 123-142. 16. Verity GL: Neurologic manifestations and complications of lymphoma . Radiol Clin North Am 6:97-109, 1968.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1973

References