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Unconvincing Evidence of SARS-CoV-2–Associated Myositis in Autopsied Muscles—Reply

Unconvincing Evidence of SARS-CoV-2–Associated Myositis in Autopsied Muscles—Reply Letters Published Online: November 15, 2021. doi:10.1001/jamaneurol.2021.4112 cific inflammatory phenomena were also seen in some muscle Conflict of Interest Disclosures: Dr Haas reported personal fees from Sun and nerve specimens, and although they were liberally la- Pharmaceuticals outside the submitted work. Dr Glass has received payment for beled myositic without myositis, they were cautiously inter- legal consulting. Dr Shellhaas serves as associate editor for Neurology, receives preted as cytokine-released changes. Without costaining royalties from UpToDate for authorship of topics on neonatal seizures, and is a MHC-I with lymphoid subsets to demonstrate T-cell– consultant for the Epilepsy Study Consortium. The Patient-Centered Outcomes Research Institute supported the Original Investigation mediated or macrophage-mediated myocytotoxicity, the con- (grant 2015C2-1507-31187). tention that patients who were comatose with COVID-19 had Additional Contributions: The authors are grateful to the investigators of the myositis as an immune response against SARS-CoV-2 is un- Neonatal Seizure Registry for their contribution to the work. substantiated. The absence of complement deposits also sup- 1. Glass HC, Soul JS, Chang T, et al. Safety of early discontinuation of antiseizure ports the absence of ongoing muscle fiber necrosis. Impor- medication after acute symptomatic neonatal seizures. JAMA Neurol. 2021;78 tantly, the case-control examinations were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Unconvincing Evidence of SARS-CoV-2–Associated Myositis in Autopsied Muscles—Reply

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2021.4339
Publisher site
See Article on Publisher Site

Abstract

Letters Published Online: November 15, 2021. doi:10.1001/jamaneurol.2021.4112 cific inflammatory phenomena were also seen in some muscle Conflict of Interest Disclosures: Dr Haas reported personal fees from Sun and nerve specimens, and although they were liberally la- Pharmaceuticals outside the submitted work. Dr Glass has received payment for beled myositic without myositis, they were cautiously inter- legal consulting. Dr Shellhaas serves as associate editor for Neurology, receives preted as cytokine-released changes. Without costaining royalties from UpToDate for authorship of topics on neonatal seizures, and is a MHC-I with lymphoid subsets to demonstrate T-cell– consultant for the Epilepsy Study Consortium. The Patient-Centered Outcomes Research Institute supported the Original Investigation mediated or macrophage-mediated myocytotoxicity, the con- (grant 2015C2-1507-31187). tention that patients who were comatose with COVID-19 had Additional Contributions: The authors are grateful to the investigators of the myositis as an immune response against SARS-CoV-2 is un- Neonatal Seizure Registry for their contribution to the work. substantiated. The absence of complement deposits also sup- 1. Glass HC, Soul JS, Chang T, et al. Safety of early discontinuation of antiseizure ports the absence of ongoing muscle fiber necrosis. Impor- medication after acute symptomatic neonatal seizures. JAMA Neurol. 2021;78 tantly, the case-control examinations were

Journal

JAMA NeurologyAmerican Medical Association

Published: Jan 22, 2022

References