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Ultrasound Measurement of Brain Atrophy in Multiple Sclerosis

Ultrasound Measurement of Brain Atrophy in Multiple Sclerosis EDITORIAL Ultrasound Measurement of Brain Atrophy in Multiple Sclerosis RAIN ATROPHY has become a significant fac- What is now needed is a prospective, long-term study tor in the evaluation of patients with multiple of all of these measurements to understand the interre- sclerosis (MS). Observed over time, there lationship among MS lesions (MRI), axonal loss (MRS), seems to be a progressive loss of brain tissue axonal damage (MRS), and atrophy (MRI and transcra- B that may start very early in the disease. Stud- nial sonography). ies of MS at postmortem have long recognized loss of brain tissue at the end of life. Recent magnetic resonance imag- Donald W. Paty, MD, FRCPC ing (MRI) studies have reemphasized brain and spinal cord Professor of Medicine, Neurology atrophy that can be measured in life, and sequential stud- 2211 Wesbrook Mall, S195 ies have shown that the tissue loss is a progressive one. Vancouver, British Columbia Canada V6T 2B5 See also page 1289 The underlying pathological feature of atrophy is REFERENCES probably a mixture of demyelination and axonal loss. Understanding the evolution of the tissue loss will be a significant advance in MS research. Magnetic resonance 1. Lumsden CE. Pathology. In: McAlpine D, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Ultrasound Measurement of Brain Atrophy in Multiple Sclerosis

JAMA Neurology , Volume 57 (9) – Sep 1, 2000

Ultrasound Measurement of Brain Atrophy in Multiple Sclerosis

Abstract

EDITORIAL Ultrasound Measurement of Brain Atrophy in Multiple Sclerosis RAIN ATROPHY has become a significant fac- What is now needed is a prospective, long-term study tor in the evaluation of patients with multiple of all of these measurements to understand the interre- sclerosis (MS). Observed over time, there lationship among MS lesions (MRI), axonal loss (MRS), seems to be a progressive loss of brain tissue axonal damage (MRS), and atrophy (MRI and transcra- B that may start very early in...
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Publisher
American Medical Association
Copyright
Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.57.9.1264
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Ultrasound Measurement of Brain Atrophy in Multiple Sclerosis RAIN ATROPHY has become a significant fac- What is now needed is a prospective, long-term study tor in the evaluation of patients with multiple of all of these measurements to understand the interre- sclerosis (MS). Observed over time, there lationship among MS lesions (MRI), axonal loss (MRS), seems to be a progressive loss of brain tissue axonal damage (MRS), and atrophy (MRI and transcra- B that may start very early in the disease. Stud- nial sonography). ies of MS at postmortem have long recognized loss of brain tissue at the end of life. Recent magnetic resonance imag- Donald W. Paty, MD, FRCPC ing (MRI) studies have reemphasized brain and spinal cord Professor of Medicine, Neurology atrophy that can be measured in life, and sequential stud- 2211 Wesbrook Mall, S195 ies have shown that the tissue loss is a progressive one. Vancouver, British Columbia Canada V6T 2B5 See also page 1289 The underlying pathological feature of atrophy is REFERENCES probably a mixture of demyelination and axonal loss. Understanding the evolution of the tissue loss will be a significant advance in MS research. Magnetic resonance 1. Lumsden CE. Pathology. In: McAlpine D,

Journal

JAMA NeurologyAmerican Medical Association

Published: Sep 1, 2000

References

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