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Type A2 Influenza Viral Infections in Children

Type A2 Influenza Viral Infections in Children Abstract • We retrospectively reviewed the manifestations of influenza A2 in 83 hospitalized young children. Our purpose was to define the spectrum of clinical illness in this age group. Findings included fever (91%), vomiting or diarrhea (49%), pharyngitis (34%), pneumonitis (29%), otitis media (24%), conjunctivitis (13%), croup (13%), and bronchiolitis (6%). Neuromuscular manifestations occurred in 16 patients (19%) and included seizures, apnea, opisthotonos, and myositis. Three children had cerebrospinal fluid pleocytosis. Children younger than 3 months of age had fever less often and gastrointestinal symptoms more often than older children. Three children died of progressive pneumonitis. We conclude that influenza A may cause a wide range of respiratory and neurologic findings in infancy and early childhood. (Am J Dis Child 132:34-36, 1978) References 1. Grist NR, Ross CAC, Scott EJ: Influenza, respiratory syncytial virus, and pneumonia in Glasgow, 1962-1965 . Br Med J 1:456-457, 1967.Crossref 2. Brocklebank JT, Court SDM, McQuillan J, et al: Influenza A infections in children . Lancet 2:497-500, 1972.Crossref 3. Howard JB, McCracken GH, Luby JP: Influenza A2 virus as a cause of croup requiring tracheotomy . J Pediatr 81:1148-1149, 1972.Crossref 4. Lindsay MI, Herrmann EC, Morrow GW, et al: Clinical, microbiologic, and pathologic features in 127 cases . JAMA 214:1825-1832, 1970.Crossref 5. Oseasohn R, Adelson L, Kaji M: Clinicopathologic study of 33 fatal cases of Asian influenza . N Engl J Med 260:509-518, 1959.Crossref 6. Simon NM, Kovner RN, Berlin BS: Acute myoglobinuria associated with type A, (Hong Kong) influenza . JAMA 212:1704-1705, 1970.Crossref 7. Middleton PJ, Alexander RM, Szymanski MT: Severe myositis during recovery from influenza . Lancet 2:533-535, 1970.Crossref 8. Bell WE, McKee AP, Utterback RA: Asian influenza virus as the cause of acute encephalitis . Neurology 8:500-503, 1958.Crossref 9. Mellman WJ: Influenza encephalitis . J Pediatr 53:292-295, 1958.Crossref 10. Riley HD Jr: Reye's syndrome . J Infect Dis 125:77-81, 1972.Crossref 11. Parrott RH, Kim HW, Vargosko AJ, et al: Serious respiratory illness as a result of Asian influenza and influenza B infections in children . J Pediatr 61:205-213, 1962.Crossref 12. Schmidt JP, Metcalf TG, Miltenberger FW: An epidemic of Asian influenza in children at Ladd Air Force Base, Alaska, 1960 . J Pediatr 61:214-219, 1962.Crossref 13. Lennette E, Schmidt N, (eds): Diagnostic Procedures for Viral and Rickettsial Infections ed 4. New York, American Public Health Assoc, Inc, 1969. 14. Podosin RL, Felton WL: The clinical picture of Far East influenza occurring at the fourth national Boy Scout jamboree . N Engl J Med 258:778-782, 1958.Crossref 15. Kerr AA, Downham MAPS, McQuillin J, et al: Gastric flu: Influenza B causing abdominal symptoms in children . Lancet 1:292-294, 1975. 16. Hall CB, Douglas G Jr: Nosocomial influenza infection as a cause of intercurrent fevers in infants . Pediatr 55:673-677, 1975. 17. Bruhn F, Mokrohisky S, McIntosh K: Apnea associated with respiratory syncytial virus infection in young infants . J Pediatr 90:382-386, 1977.Crossref 18. Strangert K: Clinical course and prognosis of whooping-cough in Swedish children during the first six months of life . Scand J Infect Dis 2:45-51, 1970. 19. Flewett TH, Hoult JG: Influenzal encephalopathy and postinfluenzal encephalitis . Lancet 2:11-14, 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120260036007
Publisher site
See Article on Publisher Site

Abstract

Abstract • We retrospectively reviewed the manifestations of influenza A2 in 83 hospitalized young children. Our purpose was to define the spectrum of clinical illness in this age group. Findings included fever (91%), vomiting or diarrhea (49%), pharyngitis (34%), pneumonitis (29%), otitis media (24%), conjunctivitis (13%), croup (13%), and bronchiolitis (6%). Neuromuscular manifestations occurred in 16 patients (19%) and included seizures, apnea, opisthotonos, and myositis. Three children had cerebrospinal fluid pleocytosis. Children younger than 3 months of age had fever less often and gastrointestinal symptoms more often than older children. Three children died of progressive pneumonitis. We conclude that influenza A may cause a wide range of respiratory and neurologic findings in infancy and early childhood. (Am J Dis Child 132:34-36, 1978) References 1. Grist NR, Ross CAC, Scott EJ: Influenza, respiratory syncytial virus, and pneumonia in Glasgow, 1962-1965 . Br Med J 1:456-457, 1967.Crossref 2. Brocklebank JT, Court SDM, McQuillan J, et al: Influenza A infections in children . Lancet 2:497-500, 1972.Crossref 3. Howard JB, McCracken GH, Luby JP: Influenza A2 virus as a cause of croup requiring tracheotomy . J Pediatr 81:1148-1149, 1972.Crossref 4. Lindsay MI, Herrmann EC, Morrow GW, et al: Clinical, microbiologic, and pathologic features in 127 cases . JAMA 214:1825-1832, 1970.Crossref 5. Oseasohn R, Adelson L, Kaji M: Clinicopathologic study of 33 fatal cases of Asian influenza . N Engl J Med 260:509-518, 1959.Crossref 6. Simon NM, Kovner RN, Berlin BS: Acute myoglobinuria associated with type A, (Hong Kong) influenza . JAMA 212:1704-1705, 1970.Crossref 7. Middleton PJ, Alexander RM, Szymanski MT: Severe myositis during recovery from influenza . Lancet 2:533-535, 1970.Crossref 8. Bell WE, McKee AP, Utterback RA: Asian influenza virus as the cause of acute encephalitis . Neurology 8:500-503, 1958.Crossref 9. Mellman WJ: Influenza encephalitis . J Pediatr 53:292-295, 1958.Crossref 10. Riley HD Jr: Reye's syndrome . J Infect Dis 125:77-81, 1972.Crossref 11. Parrott RH, Kim HW, Vargosko AJ, et al: Serious respiratory illness as a result of Asian influenza and influenza B infections in children . J Pediatr 61:205-213, 1962.Crossref 12. Schmidt JP, Metcalf TG, Miltenberger FW: An epidemic of Asian influenza in children at Ladd Air Force Base, Alaska, 1960 . J Pediatr 61:214-219, 1962.Crossref 13. Lennette E, Schmidt N, (eds): Diagnostic Procedures for Viral and Rickettsial Infections ed 4. New York, American Public Health Assoc, Inc, 1969. 14. Podosin RL, Felton WL: The clinical picture of Far East influenza occurring at the fourth national Boy Scout jamboree . N Engl J Med 258:778-782, 1958.Crossref 15. Kerr AA, Downham MAPS, McQuillin J, et al: Gastric flu: Influenza B causing abdominal symptoms in children . Lancet 1:292-294, 1975. 16. Hall CB, Douglas G Jr: Nosocomial influenza infection as a cause of intercurrent fevers in infants . Pediatr 55:673-677, 1975. 17. Bruhn F, Mokrohisky S, McIntosh K: Apnea associated with respiratory syncytial virus infection in young infants . J Pediatr 90:382-386, 1977.Crossref 18. Strangert K: Clinical course and prognosis of whooping-cough in Swedish children during the first six months of life . Scand J Infect Dis 2:45-51, 1970. 19. Flewett TH, Hoult JG: Influenzal encephalopathy and postinfluenzal encephalitis . Lancet 2:11-14, 1958.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1978

References