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Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus EDITORIAL Greater Cardiovascular Risks and Greater Benefits of Therapy YPE 2 DIABETES MELLITUS is associated with Treatment Trial. In 1501 diabetic persons randomized a 2- to 3-fold increased risk of cardiovas- to a target diastolic BP of less than 90 mm Hg, less than cular morbidity and mortality. The risk is 85 mm Hg, or less than 80 mm Hg, felodipine-based an- approximately 2-fold in men and 4-fold in tihypertensive therapy reduced total stroke by 30% in the T women. The risk of coronary disease is most aggressively treated group compared with the least increased 4-fold in diabetic persons compared with non- aggressively treated group, although the result was not diabetic persons, and the risks of myocardial infarction statistically significant (P = .34), probably because of the (MI) and death from coronary disease are the same in relatively small cohort of diabetic persons and shorter diabetic persons without previous MI as in nondiabetic duration of follow-up. persons with previous MI. The relative risk of stroke in In addition to stroke, other cardiovascular end points diabetic persons is 2- to 3-fold the risk in nondiabetic are reduced by treating hypertension in persons with persons, and there is a greater relative http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinte.159.10.1033
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Greater Cardiovascular Risks and Greater Benefits of Therapy YPE 2 DIABETES MELLITUS is associated with Treatment Trial. In 1501 diabetic persons randomized a 2- to 3-fold increased risk of cardiovas- to a target diastolic BP of less than 90 mm Hg, less than cular morbidity and mortality. The risk is 85 mm Hg, or less than 80 mm Hg, felodipine-based an- approximately 2-fold in men and 4-fold in tihypertensive therapy reduced total stroke by 30% in the T women. The risk of coronary disease is most aggressively treated group compared with the least increased 4-fold in diabetic persons compared with non- aggressively treated group, although the result was not diabetic persons, and the risks of myocardial infarction statistically significant (P = .34), probably because of the (MI) and death from coronary disease are the same in relatively small cohort of diabetic persons and shorter diabetic persons without previous MI as in nondiabetic duration of follow-up. persons with previous MI. The relative risk of stroke in In addition to stroke, other cardiovascular end points diabetic persons is 2- to 3-fold the risk in nondiabetic are reduced by treating hypertension in persons with persons, and there is a greater relative

Journal

JAMA Internal MedicineAmerican Medical Association

Published: May 24, 1999

References

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