EDITORIAL Greater Cardiovascular Risks and Greater Benefits of Therapy YPE 2 DIABETES MELLITUS is associated with Treatment Trial. In 1501 diabetic persons randomized a 2- to 3-fold increased risk of cardiovas- to a target diastolic BP of less than 90 mm Hg, less than cular morbidity and mortality. The risk is 85 mm Hg, or less than 80 mm Hg, felodipine-based an- approximately 2-fold in men and 4-fold in tihypertensive therapy reduced total stroke by 30% in the T women. The risk of coronary disease is most aggressively treated group compared with the least increased 4-fold in diabetic persons compared with non- aggressively treated group, although the result was not diabetic persons, and the risks of myocardial infarction statistically significant (P = .34), probably because of the (MI) and death from coronary disease are the same in relatively small cohort of diabetic persons and shorter diabetic persons without previous MI as in nondiabetic duration of follow-up. persons with previous MI. The relative risk of stroke in In addition to stroke, other cardiovascular end points diabetic persons is 2- to 3-fold the risk in nondiabetic are reduced by treating hypertension in persons with persons, and there is a greater relative
JAMA Internal Medicine – American Medical Association
Published: May 24, 1999
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera