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TWOFOLD EFFECT OF CORTICOTROPIN (ACTH) ON BLOOD CLOTTING AND ITS IMPLICATIONS IN SURGERY

TWOFOLD EFFECT OF CORTICOTROPIN (ACTH) ON BLOOD CLOTTING AND ITS IMPLICATIONS IN SURGERY Abstract CONTRADICTORY reports can be found in the literature regarding the effect of corticotropin (ACTH) and cortisone on blood clotting.1a, b, c This paper will attempt to reconcile the discrepancies and to shed some light upon the problem involved. In addition, potential dangers in the clinical use of adrenal cortical hormones as regards the fluidity of the blood will be discussed. The corticotropin used in this study was an LA-1 Standard lot, supplied through the courtesy of the Parke, Davis & Company Division of Clinical Investigation. The amounts of hormone used varied from 100 to 500 mg. per diem, given intramuscularly in divided, single 20 to 25 mg. doses. It was administered over periods of from one to eight days. Thirteen persons afflicted with thrombophlebitis or phlebothrombosis were treated in this preliminary study. Twelve received corticotropin, and one cortisone. Of those 13 patients, 8 had phlebothrombosis following various operative procedures. References 1. (a) Cosgriff, W. S.; Diefenbach, A. F., and Vogt, W.: Am. J. Med. 9:752, 1950.Crossref 2. (b) Smith, R. W.; Margulis, R. R.; Brennan, M. J., and Monto, R. W.: Science 112:295, 1950.Crossref 3. (c) Fahey, J. L.: Proc. Soc. Exper. Biol. & Med. 77: 491, 1951. 4. (d) Margulis, R. R.: Proceedings of the Forum Sessions , American College of Surgeons, Philadelphia, W. B. Saunders Company, 1951, p. 507. 5. Quick, A. J.: Am. J. Clin. Path. 15: 560, 1945. 6. Shapiro, S.; Sherwin, B.; Retish, M., and Campbell, H. A.: Proc. Soc. Exper. Biol. & Med. 50: 85, 1942. 7. Allen, J. G.; Molder, P. V.; Elghammer, R. M.; Grosman, B. J.; McKean, C. L.; Sanderson, M. H.; Egner, W. M., and Crosbie, J.: J. Lab. & Clin. Med. 34: 473, 1949. 8. Forsham, P. H.; Thorn, G. W.; Prunty, F. T. G., and Hills, A. G.: J. Clin. Endocrinol. 8:15, 1948. 9. Our colleague Dr. D. E. Silagyi permitted us to report this case. 10. Hume, D. M., and Moore, F. D., in Proceedings of the Second ACTH Conference , edited by J. R. Mote, Philadelphia, The Blakiston Company, 1950, p. 289. 11. Jorpes, E.; Holmgren, H., and Wilander, O.: Ztschr. mikr.-anat. Forsch. 42: 279, 1937. 12. Stuart, E. G.: Anat. Rec. 109: 351, 1951. 13. Glick, D. J.: Bull. Mt. Sinai Hosp. 17: 207, 1950. 14. Glick, D. J., and Bengt, S.: Science 113:388, 1951. 15. Loomis, E.: Personal communication to the authors. 16. Slocumb, C., in discussion on Hume & Moore,7 p. 304. Moore, F. D.: Personal communication to the authors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

TWOFOLD EFFECT OF CORTICOTROPIN (ACTH) ON BLOOD CLOTTING AND ITS IMPLICATIONS IN SURGERY

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1952.01260020093008
Publisher site
See Article on Publisher Site

Abstract

Abstract CONTRADICTORY reports can be found in the literature regarding the effect of corticotropin (ACTH) and cortisone on blood clotting.1a, b, c This paper will attempt to reconcile the discrepancies and to shed some light upon the problem involved. In addition, potential dangers in the clinical use of adrenal cortical hormones as regards the fluidity of the blood will be discussed. The corticotropin used in this study was an LA-1 Standard lot, supplied through the courtesy of the Parke, Davis & Company Division of Clinical Investigation. The amounts of hormone used varied from 100 to 500 mg. per diem, given intramuscularly in divided, single 20 to 25 mg. doses. It was administered over periods of from one to eight days. Thirteen persons afflicted with thrombophlebitis or phlebothrombosis were treated in this preliminary study. Twelve received corticotropin, and one cortisone. Of those 13 patients, 8 had phlebothrombosis following various operative procedures. References 1. (a) Cosgriff, W. S.; Diefenbach, A. F., and Vogt, W.: Am. J. Med. 9:752, 1950.Crossref 2. (b) Smith, R. W.; Margulis, R. R.; Brennan, M. J., and Monto, R. W.: Science 112:295, 1950.Crossref 3. (c) Fahey, J. L.: Proc. Soc. Exper. Biol. & Med. 77: 491, 1951. 4. (d) Margulis, R. R.: Proceedings of the Forum Sessions , American College of Surgeons, Philadelphia, W. B. Saunders Company, 1951, p. 507. 5. Quick, A. J.: Am. J. Clin. Path. 15: 560, 1945. 6. Shapiro, S.; Sherwin, B.; Retish, M., and Campbell, H. A.: Proc. Soc. Exper. Biol. & Med. 50: 85, 1942. 7. Allen, J. G.; Molder, P. V.; Elghammer, R. M.; Grosman, B. J.; McKean, C. L.; Sanderson, M. H.; Egner, W. M., and Crosbie, J.: J. Lab. & Clin. Med. 34: 473, 1949. 8. Forsham, P. H.; Thorn, G. W.; Prunty, F. T. G., and Hills, A. G.: J. Clin. Endocrinol. 8:15, 1948. 9. Our colleague Dr. D. E. Silagyi permitted us to report this case. 10. Hume, D. M., and Moore, F. D., in Proceedings of the Second ACTH Conference , edited by J. R. Mote, Philadelphia, The Blakiston Company, 1950, p. 289. 11. Jorpes, E.; Holmgren, H., and Wilander, O.: Ztschr. mikr.-anat. Forsch. 42: 279, 1937. 12. Stuart, E. G.: Anat. Rec. 109: 351, 1951. 13. Glick, D. J.: Bull. Mt. Sinai Hosp. 17: 207, 1950. 14. Glick, D. J., and Bengt, S.: Science 113:388, 1951. 15. Loomis, E.: Personal communication to the authors. 16. Slocumb, C., in discussion on Hume & Moore,7 p. 304. Moore, F. D.: Personal communication to the authors.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Jul 1, 1952

References

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