Abstract CONTRADICTORY reports can be found in the literature regarding the effect of corticotropin (ACTH) and cortisone on blood clotting.1a, b, c This paper will attempt to reconcile the discrepancies and to shed some light upon the problem involved. In addition, potential dangers in the clinical use of adrenal cortical hormones as regards the fluidity of the blood will be discussed. The corticotropin used in this study was an LA-1 Standard lot, supplied through the courtesy of the Parke, Davis & Company Division of Clinical Investigation. The amounts of hormone used varied from 100 to 500 mg. per diem, given intramuscularly in divided, single 20 to 25 mg. doses. It was administered over periods of from one to eight days. Thirteen persons afflicted with thrombophlebitis or phlebothrombosis were treated in this preliminary study. Twelve received corticotropin, and one cortisone. Of those 13 patients, 8 had phlebothrombosis following various operative procedures. References 1. (a) Cosgriff, W. S.; Diefenbach, A. F., and Vogt, W.: Am. J. Med. 9:752, 1950.Crossref 2. (b) Smith, R. W.; Margulis, R. R.; Brennan, M. J., and Monto, R. W.: Science 112:295, 1950.Crossref 3. (c) Fahey, J. L.: Proc. Soc. Exper. Biol. & Med. 77: 491, 1951. 4. (d) Margulis, R. R.: Proceedings of the Forum Sessions , American College of Surgeons, Philadelphia, W. B. Saunders Company, 1951, p. 507. 5. Quick, A. J.: Am. J. Clin. Path. 15: 560, 1945. 6. Shapiro, S.; Sherwin, B.; Retish, M., and Campbell, H. A.: Proc. Soc. Exper. Biol. & Med. 50: 85, 1942. 7. Allen, J. G.; Molder, P. V.; Elghammer, R. M.; Grosman, B. J.; McKean, C. L.; Sanderson, M. H.; Egner, W. M., and Crosbie, J.: J. Lab. & Clin. Med. 34: 473, 1949. 8. Forsham, P. H.; Thorn, G. W.; Prunty, F. T. G., and Hills, A. G.: J. Clin. Endocrinol. 8:15, 1948. 9. Our colleague Dr. D. E. Silagyi permitted us to report this case. 10. Hume, D. M., and Moore, F. D., in Proceedings of the Second ACTH Conference , edited by J. R. Mote, Philadelphia, The Blakiston Company, 1950, p. 289. 11. Jorpes, E.; Holmgren, H., and Wilander, O.: Ztschr. mikr.-anat. Forsch. 42: 279, 1937. 12. Stuart, E. G.: Anat. Rec. 109: 351, 1951. 13. Glick, D. J.: Bull. Mt. Sinai Hosp. 17: 207, 1950. 14. Glick, D. J., and Bengt, S.: Science 113:388, 1951. 15. Loomis, E.: Personal communication to the authors. 16. Slocumb, C., in discussion on Hume & Moore,7 p. 304. Moore, F. D.: Personal communication to the authors.
A.M.A. Archives Surgery – American Medical Association
Published: Jul 1, 1952
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera