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Two Trajectories to Melanoma on the Hands and Feet

Two Trajectories to Melanoma on the Hands and Feet Opinion EDITORIAL A. Hunter Shain, PhD Acral melanoma is a subtype of melanoma that occurs on the radiation, producing a common nevus, which can progress to glabrous (non–hair-bearing) skin of the hands and feet. The in- melanoma once additional mutations arise. However, the more cidence of acral melanoma is similar across people of differ- common route is for a melanocyte to acquire another muta- tion in the MAPK pathway, producing fields of poised mela- ent races and ethnicities. At the genetic level, acral melano- mas have diverse mutations nocytes that progress to melanoma once complementary mu- known to activate the mito- tations arise; the mutagenic factors operating during this route Related article page 831 gen-activated protein kinase to neoplasia remain unclear but are extraordinarily specific to 1,2 3 (MAPK) pathway. Their overall point mutation burdens are this class of acral melanomas. relatively low, but they are riddled with complex copy num- The study by Smalley and colleagues offers key observa- ber alterations, recently termed tyfonas. Tyfonas are “ty- tions to help sort out the routes to melanoma on the hands and phoons” of high-junction copy number events and fold-back feet; however, their study has limitations. Because acral nevi inversions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Two Trajectories to Melanoma on the Hands and Feet

JAMA Dermatology , Volume 157 (7) – Jul 12, 2021

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2021.0792
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL A. Hunter Shain, PhD Acral melanoma is a subtype of melanoma that occurs on the radiation, producing a common nevus, which can progress to glabrous (non–hair-bearing) skin of the hands and feet. The in- melanoma once additional mutations arise. However, the more cidence of acral melanoma is similar across people of differ- common route is for a melanocyte to acquire another muta- tion in the MAPK pathway, producing fields of poised mela- ent races and ethnicities. At the genetic level, acral melano- mas have diverse mutations nocytes that progress to melanoma once complementary mu- known to activate the mito- tations arise; the mutagenic factors operating during this route Related article page 831 gen-activated protein kinase to neoplasia remain unclear but are extraordinarily specific to 1,2 3 (MAPK) pathway. Their overall point mutation burdens are this class of acral melanomas. relatively low, but they are riddled with complex copy num- The study by Smalley and colleagues offers key observa- ber alterations, recently termed tyfonas. Tyfonas are “ty- tions to help sort out the routes to melanoma on the hands and phoons” of high-junction copy number events and fold-back feet; however, their study has limitations. Because acral nevi inversions

Journal

JAMA DermatologyAmerican Medical Association

Published: Jul 12, 2021

References