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Two Cases of Acute Pandysautonomia

Two Cases of Acute Pandysautonomia Abstract Two men had acute nonprogressive pandysautonomia. Both of them showed orthostatic hypotension, fainting in upright position, pupillary disturbances, diminished sweating, anacidity, and impotence. Case 1 showed considerable but inadequate improvement within 31 months. Case 2 recovered completely after 11 months. Clinical and pharmacodynamic investigations suggested that the main lesion was located in postganglionic fibers in case 1 and in preganglionic fibers in case 2. The cause of this disorder is unknown, although both patients had undergone substantial weight loss. References 1. Bradbury S, Eggleston C: Postural hyotension: A report of three cases . Am Heart J 1:73-86, 1925.Crossref 2. Shy GM, Drager GA: A neurological syndrome associated with orthostatic hypotension: A clinical-pathologic study . Arch Neurol 2:511-527, 1960.Crossref 3. Chokroverty S, et al: The syndrome of primary orthostatic hypotension . Brain 92:743-768, 1969.Crossref 4. Young RR, et al: Pure pan-dysautonomia with recovery . Trans Am Neurol Assoc 94:355-357, 1969. 5. Tomashefsky AF, Horwitz SF, Feingold MH: Acute autonomic neuropathy . Neurology 22:251-255, 1972.Crossref 6. Wichser J, Vijayan N, Dreyfus PM: Dysautonomia: Its significance in neurological disease . Calif Med 117:28-37, 1972. 7. Andersen O, et al: Subacute dysautonomia with incomplete recovery . Acta Neurol Scand 48:510-519, 1972.Crossref 8. AppenzellerO, Kornfeld M: Acute pandysautonomia: Clinical and morphologic study . Arch Neurol 29:334-339, 1973.Crossref 9. Haber E, et al: Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects . J Clin Endocrinol 29:1349-1355, 1969.Crossref 10. Nagatsu T, Udenfriend S: Photometric assay of dopamine-β-hydroxylase activity in human blood . Clin Chem 18:980-983, 1972. 11. Cannon WB, Rosenblueth A: The Supersensitivity of Denervated Structures: A Law of Denervation . New York, MacMillan Co, 1949. 12. Walsh FB, Hoyt WF: Clinical Neuroophthalmology . Baltimore, Md, William & Wilkins Co, 1969. 13. Scheie HG: Site of disturbance in Adie's syndrome . Arch Ophthalmol 24:225-237, 1940.Crossref 14. Coon JM, Rothman S: The nature of the pilomotor response to acetylcholine: Some observations on the pharmacodynamics of the skin . J Pharmacol 68:301-311, 1940. 15. Hyndman OR, Wolkin J: The pilocarpine sweating test: I. A valid indicator in differentiation of preganglionic and postganglionic sympathectomy . Arch Neurol Psychiatr 45:992-1006, 1941.Crossref 16. Parks VJ, et al: Sympathomimetic drugs in orthostatic hypotension . Lancet 1:1133-1136, 1961.Crossref 17. Vander AJ: Control of renin release . Physiol Rev 47:359-382, 1967. 18. Brown JJ, et al: Plasma renin concentration in relation to changes in posture . Clin Sci 30:279-284, 1966. 19. Love DR, et al: Plasma renin in idiopathic orthostatic hypotension: Differential response in subjects with probable afferent and efferent autonomic failure . Clin Sci 41:289-299, 1971. 20. Viveros OH, Arqueros L, Kirshner N: Release of catecholamines and dopamine-β-oxidase from the adrenal medulla . Life Sci 7:609-618, 1968.Crossref 21. Weinshilboum RM, et al: Proportional release of norepinephrine and dopamine-β-hydroxylase from sympathetic nerves . Science 174:1349-1351, 1971.Crossref 22. Rinshilboum R, Axelrod J: Serum dopamine-β-hydroxylase: Decrease after chemical sympathectomy . Science 173:931-934, 1971.Crossref 23. Weinshilboum R, et al: Elevation of serumdopamine-β-hydroxylase activity with forced immobilization . Nature 230:287-288, 1971.Crossref 24. Wooten GF, Cardon PV: Plasma dopamine-β-hydroxylase activity: Elevation in man during cold pressor test and exercise . Arch Neurol 28:103-106, 1973.Crossref 25. Okada F, et al: Serum dopamine-β-hydroxylase activity: Its elevation in man during mecholyl test . Brain Nerve 26:1083-1092, 1974. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Two Cases of Acute Pandysautonomia

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1975.00490450026002
Publisher site
See Article on Publisher Site

Abstract

Abstract Two men had acute nonprogressive pandysautonomia. Both of them showed orthostatic hypotension, fainting in upright position, pupillary disturbances, diminished sweating, anacidity, and impotence. Case 1 showed considerable but inadequate improvement within 31 months. Case 2 recovered completely after 11 months. Clinical and pharmacodynamic investigations suggested that the main lesion was located in postganglionic fibers in case 1 and in preganglionic fibers in case 2. The cause of this disorder is unknown, although both patients had undergone substantial weight loss. References 1. Bradbury S, Eggleston C: Postural hyotension: A report of three cases . Am Heart J 1:73-86, 1925.Crossref 2. Shy GM, Drager GA: A neurological syndrome associated with orthostatic hypotension: A clinical-pathologic study . Arch Neurol 2:511-527, 1960.Crossref 3. Chokroverty S, et al: The syndrome of primary orthostatic hypotension . Brain 92:743-768, 1969.Crossref 4. Young RR, et al: Pure pan-dysautonomia with recovery . Trans Am Neurol Assoc 94:355-357, 1969. 5. Tomashefsky AF, Horwitz SF, Feingold MH: Acute autonomic neuropathy . Neurology 22:251-255, 1972.Crossref 6. Wichser J, Vijayan N, Dreyfus PM: Dysautonomia: Its significance in neurological disease . Calif Med 117:28-37, 1972. 7. Andersen O, et al: Subacute dysautonomia with incomplete recovery . Acta Neurol Scand 48:510-519, 1972.Crossref 8. AppenzellerO, Kornfeld M: Acute pandysautonomia: Clinical and morphologic study . Arch Neurol 29:334-339, 1973.Crossref 9. Haber E, et al: Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects . J Clin Endocrinol 29:1349-1355, 1969.Crossref 10. Nagatsu T, Udenfriend S: Photometric assay of dopamine-β-hydroxylase activity in human blood . Clin Chem 18:980-983, 1972. 11. Cannon WB, Rosenblueth A: The Supersensitivity of Denervated Structures: A Law of Denervation . New York, MacMillan Co, 1949. 12. Walsh FB, Hoyt WF: Clinical Neuroophthalmology . Baltimore, Md, William & Wilkins Co, 1969. 13. Scheie HG: Site of disturbance in Adie's syndrome . Arch Ophthalmol 24:225-237, 1940.Crossref 14. Coon JM, Rothman S: The nature of the pilomotor response to acetylcholine: Some observations on the pharmacodynamics of the skin . J Pharmacol 68:301-311, 1940. 15. Hyndman OR, Wolkin J: The pilocarpine sweating test: I. A valid indicator in differentiation of preganglionic and postganglionic sympathectomy . Arch Neurol Psychiatr 45:992-1006, 1941.Crossref 16. Parks VJ, et al: Sympathomimetic drugs in orthostatic hypotension . Lancet 1:1133-1136, 1961.Crossref 17. Vander AJ: Control of renin release . Physiol Rev 47:359-382, 1967. 18. Brown JJ, et al: Plasma renin concentration in relation to changes in posture . Clin Sci 30:279-284, 1966. 19. Love DR, et al: Plasma renin in idiopathic orthostatic hypotension: Differential response in subjects with probable afferent and efferent autonomic failure . Clin Sci 41:289-299, 1971. 20. Viveros OH, Arqueros L, Kirshner N: Release of catecholamines and dopamine-β-oxidase from the adrenal medulla . Life Sci 7:609-618, 1968.Crossref 21. Weinshilboum RM, et al: Proportional release of norepinephrine and dopamine-β-hydroxylase from sympathetic nerves . Science 174:1349-1351, 1971.Crossref 22. Rinshilboum R, Axelrod J: Serum dopamine-β-hydroxylase: Decrease after chemical sympathectomy . Science 173:931-934, 1971.Crossref 23. Weinshilboum R, et al: Elevation of serumdopamine-β-hydroxylase activity with forced immobilization . Nature 230:287-288, 1971.Crossref 24. Wooten GF, Cardon PV: Plasma dopamine-β-hydroxylase activity: Elevation in man during cold pressor test and exercise . Arch Neurol 28:103-106, 1973.Crossref 25. Okada F, et al: Serum dopamine-β-hydroxylase activity: Its elevation in man during mecholyl test . Brain Nerve 26:1083-1092, 1974.

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1975

References