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Twin Studies and Genetic Models of Schizophrenia

Twin Studies and Genetic Models of Schizophrenia Abstract To the Editor.— The elegant and important data reported by Farmer and colleagues1 raise several issues that deserve comment. A different interpretation of their data would be to exclude from analysis those twin pairs with one twin with an affective disorder and one schizophrenic twin, on the grounds that there is a reasonable possibility of a misdiagnosed affective psychosis in the schizophrenic twin. Reanalysis of the remainder of the sample lends support to the possibility of a single-gene dominant form of schizophrenia.The co-occurrence of schizophrenia and affective psychosis in the same identical twin pair is more likely (in any individual case) to be due to misdiagnosis of the "schizophrenic" twin than to a genetic relationship between schizophrenia and mood-incongruent affective disorders (as suggested by Farmer and associates). Patients with early-onset affective psychoses often receive schizophrenic diagnoses because they tend to have more bizarre and psychotic symptoms than patients References 1. Farmer AE, McGuffin P, Gottesman II: Twin concordance for DSM-III schizophrenia: Scrutinizing the validity of the definition . Arch Gen Psychiatry 1987;44:634-644.Crossref 2. Ballenger JC, Reus VI, Post RM: The 'atypical' clinical picture of adolescent mania . Am J Psychiatry 1982;139:602-606. 3. Joyce PR: Age of onset in bipolar affective disorder and misdiagnosis as schizophrenia . Psychol Med 1984;14:145-149.Crossref 4. Baron M, Gruen R, Asnis L, Kane J: Schizoaffective illness, schizophrenia and affective disorders: Morbidity risk and genetic transmission . Acta Psychiatr Scand 1982;65:253-262.Crossref 5. Baron M, Gruen R, Rainer JD, Kane J, Asnis L, Lord S: A family study of schizophrenic and normal control probands: Implications for the spectrum concept of schizophrenia . Am J Psychiatry 1985;142:447-455. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Twin Studies and Genetic Models of Schizophrenia

Archives of General Psychiatry , Volume 45 (9) – Sep 1, 1988

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1988.01800330110016
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The elegant and important data reported by Farmer and colleagues1 raise several issues that deserve comment. A different interpretation of their data would be to exclude from analysis those twin pairs with one twin with an affective disorder and one schizophrenic twin, on the grounds that there is a reasonable possibility of a misdiagnosed affective psychosis in the schizophrenic twin. Reanalysis of the remainder of the sample lends support to the possibility of a single-gene dominant form of schizophrenia.The co-occurrence of schizophrenia and affective psychosis in the same identical twin pair is more likely (in any individual case) to be due to misdiagnosis of the "schizophrenic" twin than to a genetic relationship between schizophrenia and mood-incongruent affective disorders (as suggested by Farmer and associates). Patients with early-onset affective psychoses often receive schizophrenic diagnoses because they tend to have more bizarre and psychotic symptoms than patients References 1. Farmer AE, McGuffin P, Gottesman II: Twin concordance for DSM-III schizophrenia: Scrutinizing the validity of the definition . Arch Gen Psychiatry 1987;44:634-644.Crossref 2. Ballenger JC, Reus VI, Post RM: The 'atypical' clinical picture of adolescent mania . Am J Psychiatry 1982;139:602-606. 3. Joyce PR: Age of onset in bipolar affective disorder and misdiagnosis as schizophrenia . Psychol Med 1984;14:145-149.Crossref 4. Baron M, Gruen R, Asnis L, Kane J: Schizoaffective illness, schizophrenia and affective disorders: Morbidity risk and genetic transmission . Acta Psychiatr Scand 1982;65:253-262.Crossref 5. Baron M, Gruen R, Rainer JD, Kane J, Asnis L, Lord S: A family study of schizophrenic and normal control probands: Implications for the spectrum concept of schizophrenia . Am J Psychiatry 1985;142:447-455.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Sep 1, 1988

References