Abstract An outstanding characteristic of all neoplasms is their tendency to reproduce to a limited extent the design and function of the parent tissue, emphasizing the importance of histogenesis in the interpretation of their pathology. In tumors of the giant cell group, attention on the pathologic side has been directed usually to only the histologic appearances of these lesions, and because of this shortcoming, much confusion has arisen in classifying these growths, the microscopic resemblance of some of these tumors to granulation tissue having led to a seemingly endless debate regarding their inflammatory or neoplastic nature. In the studies summarized in this article, attention has been directed to the histogenic rather than to the histologic aspects of these lesions, and by an analysis which traces the origin of these tumors to embryonic functions, a fundamental pathologic relationship has been established between various forms of giant cell tumors heretofore considered under separate References 1. Geschickter, C. F., and Copeland, M. M.: Osteitis Fibrosa and Giant Cell Tumor , Arch. Surg. 19:169 ( (Aug.) ) 1929.Crossref 2. Von Recklinghausen: Die Fibrose oder deformierende Ostitis die Osteomalacie und die osteoplastiche Carcinose , Festschr. z. Rudolf Virchow , 1891. 3. Macewen, W.: The Growth of Bone , Glasgow, James Macelhose and Sons, 1912. 4. Bloodgood, J. C.: Epulis , Am. Pract. Surg. 6:818, 1909. 5. Scudder, C. L.: Tumors of the Jaw , Philadelphia, W. B. Saunders Company, 1912. 6. Konjetzny, G. E.: Die sogenannte "lokalisierte Ostitis fibrosa," Arch. f. klin. Chir. 121:567, 1922. 7. Lubarsch: Die Bedeutung des Traumas zur Enstehung und Wachstum krankhafter Gewachse , Med. Klin. 41:1651, 1912. 8. Pommer, G.: Zur Kenntnis der progressiven Hematom und Phlegmasieveränderungen , Arch. f. Orthop. u. Unfall. Chir. 17:17, 1919.Crossref 9. Lexer, E.: Die Enstehung entzündlicher Knockenherde , Arch. f. klin. Chir. 71:1, 1903. 10. Cone, S.: Ossifying Hematoma , J. Bone & Joint Surg. 10:474, 1928.
Archives of Surgery – American Medical Association
Published: Jul 1, 1930
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