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Tuberculosis Cutis Miliaris Acuta Generalisata: Report of a Case in an Adult and Review of the Literature

Tuberculosis Cutis Miliaris Acuta Generalisata: Report of a Case in an Adult and Review of the... Abstract Tuberculosis cutis miliaris acuta generalisata is a rare form of cutaneous tuberculosis which occurs primarily in children from the dissemination of pulmonary or meningeal tuberculosis, or after various exanthematous diseases. Papulovesicles, pustules, macules, purpuric lesions, and subcutaneous nodules may be present. The histologic picture of an early lesion consists of a focal area of necrosis and abscess formation containing numerous tubercle bacilli surrounded by a nonspecific dermal inflammatory infiltrate. This report describes a case of tuberculosis cutis miliaris acuta in a 30-year-old white man. Only 15 cases in adults have been reported previously; the data are tabulated. References 1. Meyer, P.: Zwei Fälle von Metastatischer Hauttuberkulose , Inaug Dissert Kiel 1889 , pp 14 (Druck von H. Fiencke). 2. Naegeli, O.: Über Haematogene Hauttuberkulose , München Med Wschr 15:450-451 ( (April 12) ) 1898. 3. Nobl, G.: Zur Klinik und Histologie Seltener Formen der Hauttuberkulose , Arch Derm Syph , Festschrift fur Moriz Kaposi, 811-867, 1900. 4. Bruusgaard, E.: Beitrag zu den tuberkulösen Hauteruptionen , Arch Derm Syph 67:227-237, 1903.Crossref 5. Hedinger, E.: Miliartuberkulose der Haut bei Tuberkulose der Aorta abdominalis , Frankfurt Z Path 2:121-124, 1909. 6. Melik, W.: Tuberculosis Miliaris Cutis bei einem Erwachsenen , Dermat Ztschr 50:199-204 ( (May) ) 1927.Crossref 7. Leibowitz, S.: Tuberculous Sepsis With a Myeloblastic Blood Picture , Arch Path 25:365-374 ( (March) ) 1938. 8. Lees, A.W., and Munro, I.D.: Skin Lesions and Deafness in Disseminated Tuberculosis , Brit Med J 1:496-499 ( (Feb 27) ) 1954.Crossref 9. Platou, R.V., and Lennox, R.H.: Tuberculous Complexes in Children , Amer Rev Tuberc 74:160-172 ( (Aug) ) 1956. 10. Montgomery, H.: Histopathology of Various Types of Cutaneous Tuberculosis , Arch Derm Syph 35:698-715 ( (April) ) 1937.Crossref 11. Tileston, W.: Disseminated Miliary Tuberculosis of the Skin , Arch Intern Med 4:21-31 ( (July) ) 1909.Crossref 12. Wise, F.: Miliary Tuberculosis of the Skin, Lichen Scrofulosorum and the Papulotuberculids , J Cutan Dis 37:105-124 ( (Feb) ) 1919. 13. Leiner, C., and Spieler, F.: Über disseminierte Hauttuberkulosen in Kindesalter , Ergeb Inn Med Kinderheilk 7:59-114, 1911. 14. Jenkins, D.C., and Wolinsky, E.: " Mycobacterial Diseases of the Lung and Bronchial Tree: Treatment of Active Pulmonary Tuberculosis ," in Baum, G.L. (ed.): Textbook of Pulmonary Diseases , Boston: Little, Brown and Company, 1965, pp 210-255. 15. Fox, T.C.: On Acne Scrofulosorum in Infants , Brit J Derm 7:340-348 ( (Nov) ) 1895. 16. Rensburg, H.: Hauttuberkulide , Jahrb Kinderheilk 59:360-366 (No. (3) ) 1904. 17. Leiner, C., and Spieler, F.: Zum Nachweis der Brazillären Atiologie der Follikulitis , Arch Derm Syph 81:221-232, 1906.Crossref 18. Hamburger, F.: Ueber Hauttuberkulide in Säuglingsalter , Munchen Med Wschr 55:107-109 ( (Jan 21) ) 1908. 19. Shaw, H., and Laird, A.: The Diagnosis of Tuberculosis in Young Children , Arch Ped 26:481-489 ( (July) ) 1909. 20. Wronker, B.M.: Papulonecrotic Tuberculides in Infants , Amer J Dis Child 5:447-456 ( (June) ) 1913. 21. Northrup, W.P.: Disseminated Miliary Tuberculosis of Lungs and Skin , Amer J Dis Child 7:24-31 ( (Jan) ) 1914. 22. Myers, J.: Natural History of Tuberculosis in the Human Body; Forty-five Years of Observation , JAMA 194:1086-1092 ( (Dec 6) ) 1965.Crossref 23. Leichtgenstein, O.: Acute Miliartuberkel der Haut Bei Allgemeiner Acuter Miliartuberculose , Munchen Med Wschr 1:1-3 ( (Jan 5) ) 1897. 24. Tobler, L.: Disseminierte Hauttuberkulose nach akuten Infektiösen Exanthem , Jahrb Kinderheilk 59:345-359 (No. (3) ) 1904. 25. Gaucher and Druelle: Tuberculose Cutaneé Papuleuse Consecutive a La Rougeole , J Mal Cutan Syph 16:106-108 ( (Feb) ) 1904. 26. Leiner, C.: " Tuberkulose Erkrankungen der Haut ," in Pfaundler, M., and Schlossman, A. (eds.): Handbuch der Kinderheilkunde , Leipzig: F. C. W. Vogel, 2:949-956, 1909. 27. Hamburegr, F.: Ein Fall von Angeborener Tuberkulose , Beitr Klin Tuberk 5:197-204 (No. (2) ) 1906.Crossref 28. Leopold, J., and Rosenstern, T.: The Significance of Tuberculids in the Diagnosis of Tuberculosis in Infants , JAMA 55:1721-1725 ( (Nov 12) ) 1910.Crossref 29. Little, E.G.: Case of Acute Miliary Tuberculosis Cutis , Brit J Derm 28:243-245 ( (July) -Sept) 1916. 30. Sundt, H.: A Case of Lupus Disseminatus (Post-Exanthematic Miliary Tuberculosis Cutis) , Brit J Derm 37:316-324 ( (July) ) 1925.Crossref 31. Stohr, D.: Fall von Miliartuberkulose der Haut in anergischen Stadium der Masern , Wien Med Wschr 77:590-591 ( (April 30) ) 1927. 32. Meijer, E.J.: Miliartuberculose van de Huid , Nederl Maandschr Geneesk 15:346-348, 1928. 33. Vail, S.S.: The Problem of Acute Miliary Tuberculosis (Rus.) , Vop Tuberk 7:629-632 ( (June) ) 1929. 34. Northrup, W.P.: General Tuberculosis in a Child Including the Skin , Amer J Obstet 72:554-555 ( (Sept) ) 1915. 35. Sales, G.: A Propos d'une observation de tuberculides papulo-nécrotiques avec granulie terminale , Arch Med Enf 25:513-536 ( (Sept) ) 1922. 36. Nedelman, E.: Beitrag zur Kenntnis der Tuberculosis Cutis Miliaris Acuta Generalisata im Kindesalter , Jahrb Kinderh 134:24-28 ( (Dec) ) 1932. 37. Geipel, P.: Die Beteiligung der Haut bei Miliartuberkulose , Virchow Arch Path Anat 286:591-603 ( (Oct) ) 1932.Crossref 38. Follman, J.: Tuberculosis cutis miliaris ulcerosa haemorhagica infantum , Derm Wschr 103:1061-1063 ( (Aug) ) 1936. 39. Rotsteinowa, H.: Wrzodziejace Postaci Grúzlicy Prosówkowej , Prezegl Dermat 32:16-27 ( (March) ) 1937. 40. Schmidt, P.W.: Zur Frage der atypischen hämatogenen Hauttuberkulosen (Tuberculosis nodosa abscedens disseminata, Tbc. lichenoides circinata, Tuberkulide der Kinder, Tbc. papulopustulosa, Mastitis tuberculosa obliterans) , Arch Derm Syph 175:539-564 ( (May 15) ) 1937.Crossref 41. Schmidt, P.W.: Die Klinik der haematogenen Tuberkulosen der Haut , Med Welt 12:46-51 ( (Jan 8) ) 1938. 42. Kux, A.: Tbc. disseminata cutis u kojenca , Bratisl Lek Listy 16:29-35 ( (Jan) ) 1936. 43. Gori Savellini, D.: Sopra Un Caso Di Gomme Tubercolari Multiple Disseminate In Un Lattante , Atti Accad Fisiocr Siena (Studi d Fac med Senese) 13:18, 1946. 44. Sarrouy, C.; Venezia, R.; and Debrie, M.: Tuberculose miliare cutanée de l'enfant, á propos d'une observation , Bull Soc Med Hop Paris 70:537-540 ( (May 14) ) 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Tuberculosis Cutis Miliaris Acuta Generalisata: Report of a Case in an Adult and Review of the Literature

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1969.01610190070013
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Abstract

Abstract Tuberculosis cutis miliaris acuta generalisata is a rare form of cutaneous tuberculosis which occurs primarily in children from the dissemination of pulmonary or meningeal tuberculosis, or after various exanthematous diseases. Papulovesicles, pustules, macules, purpuric lesions, and subcutaneous nodules may be present. The histologic picture of an early lesion consists of a focal area of necrosis and abscess formation containing numerous tubercle bacilli surrounded by a nonspecific dermal inflammatory infiltrate. This report describes a case of tuberculosis cutis miliaris acuta in a 30-year-old white man. Only 15 cases in adults have been reported previously; the data are tabulated. References 1. Meyer, P.: Zwei Fälle von Metastatischer Hauttuberkulose , Inaug Dissert Kiel 1889 , pp 14 (Druck von H. Fiencke). 2. Naegeli, O.: Über Haematogene Hauttuberkulose , München Med Wschr 15:450-451 ( (April 12) ) 1898. 3. Nobl, G.: Zur Klinik und Histologie Seltener Formen der Hauttuberkulose , Arch Derm Syph , Festschrift fur Moriz Kaposi, 811-867, 1900. 4. Bruusgaard, E.: Beitrag zu den tuberkulösen Hauteruptionen , Arch Derm Syph 67:227-237, 1903.Crossref 5. Hedinger, E.: Miliartuberkulose der Haut bei Tuberkulose der Aorta abdominalis , Frankfurt Z Path 2:121-124, 1909. 6. Melik, W.: Tuberculosis Miliaris Cutis bei einem Erwachsenen , Dermat Ztschr 50:199-204 ( (May) ) 1927.Crossref 7. Leibowitz, S.: Tuberculous Sepsis With a Myeloblastic Blood Picture , Arch Path 25:365-374 ( (March) ) 1938. 8. Lees, A.W., and Munro, I.D.: Skin Lesions and Deafness in Disseminated Tuberculosis , Brit Med J 1:496-499 ( (Feb 27) ) 1954.Crossref 9. Platou, R.V., and Lennox, R.H.: Tuberculous Complexes in Children , Amer Rev Tuberc 74:160-172 ( (Aug) ) 1956. 10. Montgomery, H.: Histopathology of Various Types of Cutaneous Tuberculosis , Arch Derm Syph 35:698-715 ( (April) ) 1937.Crossref 11. Tileston, W.: Disseminated Miliary Tuberculosis of the Skin , Arch Intern Med 4:21-31 ( (July) ) 1909.Crossref 12. Wise, F.: Miliary Tuberculosis of the Skin, Lichen Scrofulosorum and the Papulotuberculids , J Cutan Dis 37:105-124 ( (Feb) ) 1919. 13. Leiner, C., and Spieler, F.: Über disseminierte Hauttuberkulosen in Kindesalter , Ergeb Inn Med Kinderheilk 7:59-114, 1911. 14. Jenkins, D.C., and Wolinsky, E.: " Mycobacterial Diseases of the Lung and Bronchial Tree: Treatment of Active Pulmonary Tuberculosis ," in Baum, G.L. (ed.): Textbook of Pulmonary Diseases , Boston: Little, Brown and Company, 1965, pp 210-255. 15. Fox, T.C.: On Acne Scrofulosorum in Infants , Brit J Derm 7:340-348 ( (Nov) ) 1895. 16. Rensburg, H.: Hauttuberkulide , Jahrb Kinderheilk 59:360-366 (No. (3) ) 1904. 17. Leiner, C., and Spieler, F.: Zum Nachweis der Brazillären Atiologie der Follikulitis , Arch Derm Syph 81:221-232, 1906.Crossref 18. Hamburger, F.: Ueber Hauttuberkulide in Säuglingsalter , Munchen Med Wschr 55:107-109 ( (Jan 21) ) 1908. 19. Shaw, H., and Laird, A.: The Diagnosis of Tuberculosis in Young Children , Arch Ped 26:481-489 ( (July) ) 1909. 20. Wronker, B.M.: Papulonecrotic Tuberculides in Infants , Amer J Dis Child 5:447-456 ( (June) ) 1913. 21. Northrup, W.P.: Disseminated Miliary Tuberculosis of Lungs and Skin , Amer J Dis Child 7:24-31 ( (Jan) ) 1914. 22. Myers, J.: Natural History of Tuberculosis in the Human Body; Forty-five Years of Observation , JAMA 194:1086-1092 ( (Dec 6) ) 1965.Crossref 23. Leichtgenstein, O.: Acute Miliartuberkel der Haut Bei Allgemeiner Acuter Miliartuberculose , Munchen Med Wschr 1:1-3 ( (Jan 5) ) 1897. 24. Tobler, L.: Disseminierte Hauttuberkulose nach akuten Infektiösen Exanthem , Jahrb Kinderheilk 59:345-359 (No. (3) ) 1904. 25. Gaucher and Druelle: Tuberculose Cutaneé Papuleuse Consecutive a La Rougeole , J Mal Cutan Syph 16:106-108 ( (Feb) ) 1904. 26. Leiner, C.: " Tuberkulose Erkrankungen der Haut ," in Pfaundler, M., and Schlossman, A. (eds.): Handbuch der Kinderheilkunde , Leipzig: F. C. W. Vogel, 2:949-956, 1909. 27. Hamburegr, F.: Ein Fall von Angeborener Tuberkulose , Beitr Klin Tuberk 5:197-204 (No. (2) ) 1906.Crossref 28. Leopold, J., and Rosenstern, T.: The Significance of Tuberculids in the Diagnosis of Tuberculosis in Infants , JAMA 55:1721-1725 ( (Nov 12) ) 1910.Crossref 29. Little, E.G.: Case of Acute Miliary Tuberculosis Cutis , Brit J Derm 28:243-245 ( (July) -Sept) 1916. 30. Sundt, H.: A Case of Lupus Disseminatus (Post-Exanthematic Miliary Tuberculosis Cutis) , Brit J Derm 37:316-324 ( (July) ) 1925.Crossref 31. Stohr, D.: Fall von Miliartuberkulose der Haut in anergischen Stadium der Masern , Wien Med Wschr 77:590-591 ( (April 30) ) 1927. 32. Meijer, E.J.: Miliartuberculose van de Huid , Nederl Maandschr Geneesk 15:346-348, 1928. 33. Vail, S.S.: The Problem of Acute Miliary Tuberculosis (Rus.) , Vop Tuberk 7:629-632 ( (June) ) 1929. 34. Northrup, W.P.: General Tuberculosis in a Child Including the Skin , Amer J Obstet 72:554-555 ( (Sept) ) 1915. 35. Sales, G.: A Propos d'une observation de tuberculides papulo-nécrotiques avec granulie terminale , Arch Med Enf 25:513-536 ( (Sept) ) 1922. 36. Nedelman, E.: Beitrag zur Kenntnis der Tuberculosis Cutis Miliaris Acuta Generalisata im Kindesalter , Jahrb Kinderh 134:24-28 ( (Dec) ) 1932. 37. Geipel, P.: Die Beteiligung der Haut bei Miliartuberkulose , Virchow Arch Path Anat 286:591-603 ( (Oct) ) 1932.Crossref 38. Follman, J.: Tuberculosis cutis miliaris ulcerosa haemorhagica infantum , Derm Wschr 103:1061-1063 ( (Aug) ) 1936. 39. Rotsteinowa, H.: Wrzodziejace Postaci Grúzlicy Prosówkowej , Prezegl Dermat 32:16-27 ( (March) ) 1937. 40. Schmidt, P.W.: Zur Frage der atypischen hämatogenen Hauttuberkulosen (Tuberculosis nodosa abscedens disseminata, Tbc. lichenoides circinata, Tuberkulide der Kinder, Tbc. papulopustulosa, Mastitis tuberculosa obliterans) , Arch Derm Syph 175:539-564 ( (May 15) ) 1937.Crossref 41. Schmidt, P.W.: Die Klinik der haematogenen Tuberkulosen der Haut , Med Welt 12:46-51 ( (Jan 8) ) 1938. 42. Kux, A.: Tbc. disseminata cutis u kojenca , Bratisl Lek Listy 16:29-35 ( (Jan) ) 1936. 43. Gori Savellini, D.: Sopra Un Caso Di Gomme Tubercolari Multiple Disseminate In Un Lattante , Atti Accad Fisiocr Siena (Studi d Fac med Senese) 13:18, 1946. 44. Sarrouy, C.; Venezia, R.; and Debrie, M.: Tuberculose miliare cutanée de l'enfant, á propos d'une observation , Bull Soc Med Hop Paris 70:537-540 ( (May 14) ) 1954.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1969

References