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Tuberculin Reaction in Children Treated With Isoniazid

Tuberculin Reaction in Children Treated With Isoniazid Abstract • This study involved 370 children infected by Mycobacterium tuberculosis. Follow-up tests, three to nine years after a course of isoniazid treatment, showed that the tuberculin reactions remained strongly positive, although some fluctuation in size was observed. The persistence of tuberculin hypersensitivity in these patients was considered an asset, as delayed-type hypersensitivity and cell-mediated immunity are related closely, according to recent studies on antituberculosis immunology. With the risk of endogenous disease removed by isoniazid treatment, the patients gained a bonus of cell-mediated immunity to protect them from future exogenous reinfection. (Am J Dis Child 1983;137:1090-1092) References 1. Blatman S, Rapmund G, Newstrand D, et al: Gastric contents in primary tuberculosis . Am J Dis Child 1957;94:384-385. 2. Adams WC: Variations in the endurance of positive Mantoux reactions in primary childhood tuberculosis . Am Rev Respir Dis 1960;81:955. 3. Miller FJW, Seal RME, Taylor MD: Tuberculosis in Children . Boston, Little Brown & Co, 1963. 4. Veening GJ: Long term isoniazid prophylaxis: Controlled trial on INH prophylaxis after recent tuberculin conversion in young adults . Bull Int Union Tuberc 1968;41:169-171. 5. Ferebee SH: Controlled chemoprophylaxis trials in tuberculosis: A general review . Adv Tuberc Res 1970;17:28-106. 6. Narain RAJ, Bagga AS, Naganna K, et al: Influence of isoniazid on naturally acquired tuberculin allergy and on induction of allergy by BCG vaccination . Bull WHO 1970;43:53-64. 7. Adams J: Reversal of tuberculin reaction in early tuberculosis . Dis Chest 1959;35:348-356.Crossref 8. Hall M: Reversion of positive tuberculin reactions . Med Officer 1960;104:351-352. 9. Hsu K: Prophylactic chemotherapy of tuberculosis in children: A study of 11 years in Houston, Texas. Proceedings of Eighth International Congress on Diseases of the Chest, Mexico City, Oct 11-15, 1964, p 27. 10. Hsu KHK: Isoniazid in the prevention and treatment of tuberculosis: A 20-year study of the effectiveness in children . JAMA 1974;229: 528-533.Crossref 11. Edwards LB, Krohn EF: Skin sensitivity to antigens made from various acid-fast bacteria . Am J Hyg 1957;66:253-273. 12. Edwards LB, Edwards PQ, Palmer CE: Sources of tuberculin sensitivity in human populations . Acta Tuberc Scand , 1959, (suppl 47) , pp 77-97. 13. Edwards LB, Palmer CE, Affronti LF, et al: Epidemiologic studies of tuberculin sensitivity: II. Response to experimental infection with mycobacteria isolated from human sources . Am J Hyg 1960;71:218-241. 14. Hsu K: The tuberculin reaction associated with tuberculous infection . Am Rev Respir Dis 1963;87:493-503. 15. Hsu K: Studies on the specific tuberculin reaction . Am Rev Respir Dis 1964;90:36-47. 16. Grzybowski S, Galbraith JD, Dorken E: Chemoprophylaxis trials in Canadian Eskimos . Tubercle 1976;57:263-269.Crossref 17. Comstock GW, Baum G, Snider DE: Isoniazid prophylaxis among Alaskan Eskimos: A final report of the Bethel isoniazid studies . Am Rev Respir Dis 1979;119:827-830. 18. Mackaness GB: The immunology of antituberculous immunity . Am Rev Respir Dis 1968;97:337-344. 19. Mackaness GB: Cell-mediated immunity to infection . Hosp Pract 1970;5:73. 20. Truitt GL, Mackaness GB: Cell-mediated resistance to aerogenic infection of the lung . Am Rev Respir Dis 1971;104:829-843. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Tuberculin Reaction in Children Treated With Isoniazid

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1983.02140370050016
Publisher site
See Article on Publisher Site

Abstract

Abstract • This study involved 370 children infected by Mycobacterium tuberculosis. Follow-up tests, three to nine years after a course of isoniazid treatment, showed that the tuberculin reactions remained strongly positive, although some fluctuation in size was observed. The persistence of tuberculin hypersensitivity in these patients was considered an asset, as delayed-type hypersensitivity and cell-mediated immunity are related closely, according to recent studies on antituberculosis immunology. With the risk of endogenous disease removed by isoniazid treatment, the patients gained a bonus of cell-mediated immunity to protect them from future exogenous reinfection. (Am J Dis Child 1983;137:1090-1092) References 1. Blatman S, Rapmund G, Newstrand D, et al: Gastric contents in primary tuberculosis . Am J Dis Child 1957;94:384-385. 2. Adams WC: Variations in the endurance of positive Mantoux reactions in primary childhood tuberculosis . Am Rev Respir Dis 1960;81:955. 3. Miller FJW, Seal RME, Taylor MD: Tuberculosis in Children . Boston, Little Brown & Co, 1963. 4. Veening GJ: Long term isoniazid prophylaxis: Controlled trial on INH prophylaxis after recent tuberculin conversion in young adults . Bull Int Union Tuberc 1968;41:169-171. 5. Ferebee SH: Controlled chemoprophylaxis trials in tuberculosis: A general review . Adv Tuberc Res 1970;17:28-106. 6. Narain RAJ, Bagga AS, Naganna K, et al: Influence of isoniazid on naturally acquired tuberculin allergy and on induction of allergy by BCG vaccination . Bull WHO 1970;43:53-64. 7. Adams J: Reversal of tuberculin reaction in early tuberculosis . Dis Chest 1959;35:348-356.Crossref 8. Hall M: Reversion of positive tuberculin reactions . Med Officer 1960;104:351-352. 9. Hsu K: Prophylactic chemotherapy of tuberculosis in children: A study of 11 years in Houston, Texas. Proceedings of Eighth International Congress on Diseases of the Chest, Mexico City, Oct 11-15, 1964, p 27. 10. Hsu KHK: Isoniazid in the prevention and treatment of tuberculosis: A 20-year study of the effectiveness in children . JAMA 1974;229: 528-533.Crossref 11. Edwards LB, Krohn EF: Skin sensitivity to antigens made from various acid-fast bacteria . Am J Hyg 1957;66:253-273. 12. Edwards LB, Edwards PQ, Palmer CE: Sources of tuberculin sensitivity in human populations . Acta Tuberc Scand , 1959, (suppl 47) , pp 77-97. 13. Edwards LB, Palmer CE, Affronti LF, et al: Epidemiologic studies of tuberculin sensitivity: II. Response to experimental infection with mycobacteria isolated from human sources . Am J Hyg 1960;71:218-241. 14. Hsu K: The tuberculin reaction associated with tuberculous infection . Am Rev Respir Dis 1963;87:493-503. 15. Hsu K: Studies on the specific tuberculin reaction . Am Rev Respir Dis 1964;90:36-47. 16. Grzybowski S, Galbraith JD, Dorken E: Chemoprophylaxis trials in Canadian Eskimos . Tubercle 1976;57:263-269.Crossref 17. Comstock GW, Baum G, Snider DE: Isoniazid prophylaxis among Alaskan Eskimos: A final report of the Bethel isoniazid studies . Am Rev Respir Dis 1979;119:827-830. 18. Mackaness GB: The immunology of antituberculous immunity . Am Rev Respir Dis 1968;97:337-344. 19. Mackaness GB: Cell-mediated immunity to infection . Hosp Pract 1970;5:73. 20. Truitt GL, Mackaness GB: Cell-mediated resistance to aerogenic infection of the lung . Am Rev Respir Dis 1971;104:829-843.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Nov 1, 1983

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