Abstract The patch method of testing for specific hypersensitiveness to tuberculin has been in use since 1908.1 With the introduction of the Vollmer patch test, in 1937,2 there has been new interest in this technic. In the last few years many comparative studies of the patch test and intradermal (Mantoux) technics have been made. Reports vary considerably as to the relative efficiency of the two methods in detecting reactors. Some observers3 have found almost complete correlation between the results obtained with the Vollmer patch test4 and the Mantoux test with purified protein derivative5 and with old tuberculin Koch.6 Others have reported some disparities in the results obtained, having found the Vollmer patch test or patch tests with undiluted old tuberculin antigen either slightly more or slightly less sensitive than the intradermal test with various dilutions of purified protein derivative and References 1. Lautier, R.: Nouveau procédé de cuti-réaction à la tuberculine chez l'homme , Compt. rend. Soc. de biol. 64:91, 1908. 2. Nathan, E., and Kallos, P.: Ueber eine epikutane Tuberkulinreaktion bei Hauttuberkulosen bzw. Tuberkuliden , Dermat. Ztschr. 64:146, 1932.Crossref 3. Grozin, M.: The Tuberculin Patch Test , Am. J. Dis. Child. 46:17 ( (July) ) 1933.Crossref 4. Wolff, E.: Tape Test with Tuberculin Ointment , Am. Rev. Tuberc. 27:308, 1933 5. Tuberculin Ointment Patch Test , Am. J. Dis. Child. 47:764 ( (April) ) 1934 6. Vollmer, H., and Goldberger, E. W.: New Tuberculin Patch Test , Am. J. Dis. Child 54:1019 ( (Nov.) ) 1937. 7. Hart, F. D.: Tuberculin Patch Test in Children , Lancet 2:609, 1938.Crossref 8. Vollmer, H., and Goldberger, E. W.: Evaluation of the Tuberculin Patch Test (Vollmer-Lederle) , Am. J. Dis. Child. 57:1272 ( (June) ) 1939. 9. Crimm, P. D.; Cookson, H. N., and Broadbent, M.: Patch and P. P. D. Tests and X-Ray Correlation , Am. Rev. Tuberc. 43:779, 1941. 10. Smith, C. A.; Faulkner, W. H., and Corde, J. M.: Tuberculin Tests in Children: An Interpretation of Varying Intradermal Test Doses and a Comparable Series of Patch Tests , New England J. Med. 225:1008, 1941.Crossref 11. Narodick, P. H.: The Tuberculin Patch Test: Its Evaluation as Compared to Mantoux P. P. D. Test , Northwest Med. 41:193, 1942. 12. The antigen used in this preparation is tuberculin produced from a synthetic medium (purified protein derivative). Thin filter paper is saturated with the undiluted tuberculin, cut into squares 1 by 1 cm. and placed on adhesive tape 2.5 by 7.5 cm. Each strip of tape contains two such tuberculin test squares placed to either side of a control square, the latter consisting of filter paper saturated with glycerin broth. 13. Seibert, F. B.: Isolation and Properties of Purified Protein Derivative of Tuberculin , Am. Rev. Tuberc. 30:713, 1934 14. Old tuberculin Koch is prepared by growing tubercle bacilli in 5 per cent glycerin broth for six to eight weeks. After the culture is autoclaved and filtered, a clear, dark brown syrupy fluid is obtained containing glycerin, medium and products given off by the tubercle bacilli. 15. Court, D.: A Comparative Study of the Tuberculin "Patch Test" and the Intracutaneous Mantoux Test in Childhood , Brit. M. J. 1:824, 1939.Crossref 16. Pearse, A. J.; Fried, R. I., and Glover, V. A.: The Tuberculin Patch Test and the Mantoux Intradermal Test: A Comparative Study on Seven Hundred School Children , J. A. M. A. 114:227 ( (Jan. 20) ) 1940.Crossref 17. Hughes, J. G.: The New Tuberculin Patch Test: Review and Personal Experience , Memphis M. J. 15:6, 1940. 18. Fineman, A. H., and Bair, G.: Evaluation of the Tuberculin Patch Test , Am. J. Dis. Child. 60:631 ( (Sept.) ) 1940. 19. Weddington, R. E., and Arnold, W. O.: Comparative Study of Vollmer Patch Test and Mantoux Reaction in Two Hundred Cases , J. Arkansas M. Soc. 37:75, 1940. 20. Shapiro, A. D.: Patch Tuberculin Test: Study on Ninety-Six Cases , Virginia M. Monthly 68:100, 1941. 21. Peck, E. C., and Wegman, M. E.: Comparison of the Vollmer Tuberculin Patch Test with Purified Protein Derivative: Results of Tests on 880 Rural School Children in St. Mary's County, Maryland , J. Pediat. 15:219, 1939.Crossref 22. Lebovitz, E.: Mantoux vs. Patch Test , Dis. of Chest 7:53, 1941.Crossref 23. Kereszturi, E.: Present Status of the Tuberculin Patch Test , Am. Rev. Tuberc. 44:94, 1941. 24. Taylor, G.: Tuberculin Patch Test , Am. Rev. Tuberc. 40:236, 1939. 25. Weiner, S. B., and Neustadt, A.: Tuberculin Patch Test , J. Pediat. 14:752, 1939.Crossref 26. Kerr, R. B., and Winograd, A. L.: Comparative Study of Tuberculin Patch Test and Standard Intradermal Test (P. P. D.) , New England J. Med. 222:53, 1940.Crossref 27. Craig, J. D., and Scheurer, L. A.: The Vollmer Patch Test as a Routine Procedure , Arch. Pediat. 57:177, 1940. 28. Dormer, B. A., and Friedlander, J.: Comparison Between Mantoux Intradermal Test and Tuberculin Patch Test , Brit. J. Tuberc. 35:23, 1941.Crossref 29. Savage, C. L.: Comparison of Reactions to Different Tuberculins in the Same Individual , Am. Rev. Tuberc. 43: 527, 1941. 30. Feldman, F. M.: Vollmer Patch and Mantoux Test , Minnesota Med. 24:76, 1941. 31. Reisman, H. A., and Grozin, M.: The Tuberculin Test , Am. J. Dis. Child. 62:1197 ( (Dec.) ) 1941.Crossref 32. Cohen, P.: The Patch Test: Its Reliability; Comparison with Mantoux Test , California & West. Med. 56:70, 1942. 33. Longcope, W. T.: Sarcoidosis or Besnier-Boeck-Schaumann Disease: Frank Billing's Lecture , J. A. M. A. 117:1321 ( (Oct. 18) ) 1941. 34. Thomas, C. C.: Sarcoidosis , Arch. Dermat. & Syph. 47:58 ( (Jan.) ) 1943 35. The Department of Health of the City of New York supplied the material. 36. Lederle Laboratories, Inc., supplied the Vollmer test patches. 37. Martenstein, H., and Noll, R.: Statistische Untersuchungen der Tuberkulinreaction , Arch. f. Dermat. u. Syph. 158:409, 1929. 38. Sulzberger, M. B.: Dermatologic Allergy , Springfield, Ill., Charles C Thomas, Publisher, 1940, p. 230. 39. + denotes erythema; + +, erythema and induration; + + +, erythema, induration and vesiculation. 40. An isomorphic phenomenon is one in which non-specific irritation (trauma, light, heat, toxin or a primary irritant) produces reactions having the same appearance as the clinical dermatoses.
Archives of Dermatology and Syphilology – American Medical Association
Published: Apr 1, 1944
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