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Trisomy 21 (Down Syndrome) Research Perspectives

Trisomy 21 (Down Syndrome) Research Perspectives This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This book comprises the written proceedings of a symposium on Down's syndrome that was held in Boston in 1978. The editors have drawn on a group of well-recognized leaders in Down's syndrome research to submit 19 contributions to this book, which is divided into five sections. The first section discusses the epidemiology of Down's syndrome and accounts for over one third of the written pages. Ernest Hook presents a comprehensive analysis of the frequency of Down's syndrome in human populations and factors that may affect its frequency. The next three articles present observations that, when taken in aggregate, challenge the traditional assumption that the extra 21 chromosome arises only from meiotic nondisjunction in the mother. How does one reconcile the observations that 25% of persons with Down's syndrome derive the extra 21 chromosome from the father and that the majority of trisomy 21 conceptuses do not come to term but http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Trisomy 21 (Down Syndrome) Research Perspectives

American Journal of Diseases of Children , Volume 135 (9) – Sep 1, 1981

Trisomy 21 (Down Syndrome) Research Perspectives

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This book comprises the written proceedings of a symposium on Down's syndrome that was held in Boston in 1978. The editors have drawn on a group of well-recognized leaders in Down's syndrome research to submit 19 contributions to this book, which is divided into five sections. The first section discusses the epidemiology of Down's...
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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1981.02130330075029
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This book comprises the written proceedings of a symposium on Down's syndrome that was held in Boston in 1978. The editors have drawn on a group of well-recognized leaders in Down's syndrome research to submit 19 contributions to this book, which is divided into five sections. The first section discusses the epidemiology of Down's syndrome and accounts for over one third of the written pages. Ernest Hook presents a comprehensive analysis of the frequency of Down's syndrome in human populations and factors that may affect its frequency. The next three articles present observations that, when taken in aggregate, challenge the traditional assumption that the extra 21 chromosome arises only from meiotic nondisjunction in the mother. How does one reconcile the observations that 25% of persons with Down's syndrome derive the extra 21 chromosome from the father and that the majority of trisomy 21 conceptuses do not come to term but

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1981

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