Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Trifluridine in Resistant Human Herpetic Keratitis

Trifluridine in Resistant Human Herpetic Keratitis Abstract • Patients with active dendritic herpetic keratitis that was unresponsive to topical idoxuridine or vidarabine therapy were treated topically with a 1% solution of trifluridine. The dendritic ulcers healed in an average time of 6.1 days. All patients tolerated the drug well except for one patient in whom a reversible crystalline epithelial keratitis developed. References 1. Kaufman HE, Nesburn AB, Maloney ED: IDU therapy of herpes simplex . Arch Ophthalmol 67:583-591, 1962.Crossref 2. Laibson PR, Leopold IH: An evaluation of double-blind IDU therapy in 100 cases of herpetic keratitis . Trans Am Acad Ophthalmol Otolaryngol 68:22-34, 1964. 3. Coleman VR, Tsu E, Jawetz E: Treatment resistance of idoxuridine in herpetic keratitis . Proc Soc Exp Biol Med 129:761-765, 1968.Crossref 4. Hyndiuk RA, Hull DS, Schultz RO, et al: Adenine arabinoside in idoxuridine unresponsive and intolerant herpetic keratitis . Am J Ophthalmol 79:655-658, 1975. 5. McGill J, Williams H, McKinnon J, et al: Reassessment of idoxuridine therapy of herpetic keratitis . Trans Ophthalmol Soc UK 94:542-552, 1974. 6. Patterson A, Jones BR: The management of ocular herpes . Trans Ophthalmol Soc UK 87:59-84, 1967. 7. Kaufman HE, Heidelberger C: Therapeutic antiviral action of 5-trifluoromethyl-2'-deoxyuridine in herpes simplex keratitis . Science 145:585-586, 1964.Crossref 8. Hyndiuk RA, Kaufman HE: Newer compounds in therapy of herpes simplex keratitis . Arch Ophthalmol 78:600-605, 1967.Crossref 9. Wellings PC, Awdry PN, Bors FH, et al: Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers . Am J Ophthalmol 73:932-942, 1972. 10. Jawetz E, Schultz R, Coleman V, et al: Studies on herpes simplex . J Immunol 95:635-642, 1965. 11. Pavan-Langston D, Dohlman CH: A double blind clinical study of adenine arabinoside therapy in viral keratoconjunctivitis . Am J Ophthalmol 74:81-88, 1972. 12. McKinnon Jr, McGill JI, Jones BR: A coded clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of ulcerative herpetic keratitis , in Pavan-Langston D, Buchanan RAH, Alford CA Jr (eds): Adenine Arabinoside: An Antiviral Agent . New York, Raven Press, 1975, pp 401-410. 13. Coster DJ, McKinnon JR, McGill JI, et al: Clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of corneal ulcers caused by herpes simplex virus . J Infect Dis 133( (suppl) ):173-177, 1976.Crossref 14. McGill J, Holt-Wilson AD, McKinnon JR, et al: Some aspects of the clinical use of trifluorothymidine in the treatment of herpetic ulceration of the cornea . Trans Ophthalmol Soc UK 94:342-352, 1974. 15. Jones BR, McGill JI, McKinnon Jr, et al: Preliminary experience with adenine arabinoside in comparison with idoxuridine and trifluorothymidine in the management of herpetic keratitis , in Pavan-Langston D, Buchanan RAH, Alford CH Jr (eds): Adenine Arabinoside: An Antiviral Agent . Raven Press, New York, 1975 pp 411-416. 16. McGill J, Fraunfelder FT, Jones BR: Current and proposed management of ocular herpes simplex . Surv Ophthalmol 20:358-365, 1976.Crossref 17. Hyndiuk RA, Seideman S, Leibsohn JM: Treatment of vaccinial keratitis with trifluorothymidine . Arch Ophthalmol 94:1785-1786, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Trifluridine in Resistant Human Herpetic Keratitis

Loading next page...
 
/lp/american-medical-association/trifluridine-in-resistant-human-herpetic-keratitis-9qlETQAKVb
Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1978.03910060351011
Publisher site
See Article on Publisher Site

Abstract

Abstract • Patients with active dendritic herpetic keratitis that was unresponsive to topical idoxuridine or vidarabine therapy were treated topically with a 1% solution of trifluridine. The dendritic ulcers healed in an average time of 6.1 days. All patients tolerated the drug well except for one patient in whom a reversible crystalline epithelial keratitis developed. References 1. Kaufman HE, Nesburn AB, Maloney ED: IDU therapy of herpes simplex . Arch Ophthalmol 67:583-591, 1962.Crossref 2. Laibson PR, Leopold IH: An evaluation of double-blind IDU therapy in 100 cases of herpetic keratitis . Trans Am Acad Ophthalmol Otolaryngol 68:22-34, 1964. 3. Coleman VR, Tsu E, Jawetz E: Treatment resistance of idoxuridine in herpetic keratitis . Proc Soc Exp Biol Med 129:761-765, 1968.Crossref 4. Hyndiuk RA, Hull DS, Schultz RO, et al: Adenine arabinoside in idoxuridine unresponsive and intolerant herpetic keratitis . Am J Ophthalmol 79:655-658, 1975. 5. McGill J, Williams H, McKinnon J, et al: Reassessment of idoxuridine therapy of herpetic keratitis . Trans Ophthalmol Soc UK 94:542-552, 1974. 6. Patterson A, Jones BR: The management of ocular herpes . Trans Ophthalmol Soc UK 87:59-84, 1967. 7. Kaufman HE, Heidelberger C: Therapeutic antiviral action of 5-trifluoromethyl-2'-deoxyuridine in herpes simplex keratitis . Science 145:585-586, 1964.Crossref 8. Hyndiuk RA, Kaufman HE: Newer compounds in therapy of herpes simplex keratitis . Arch Ophthalmol 78:600-605, 1967.Crossref 9. Wellings PC, Awdry PN, Bors FH, et al: Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers . Am J Ophthalmol 73:932-942, 1972. 10. Jawetz E, Schultz R, Coleman V, et al: Studies on herpes simplex . J Immunol 95:635-642, 1965. 11. Pavan-Langston D, Dohlman CH: A double blind clinical study of adenine arabinoside therapy in viral keratoconjunctivitis . Am J Ophthalmol 74:81-88, 1972. 12. McKinnon Jr, McGill JI, Jones BR: A coded clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of ulcerative herpetic keratitis , in Pavan-Langston D, Buchanan RAH, Alford CA Jr (eds): Adenine Arabinoside: An Antiviral Agent . New York, Raven Press, 1975, pp 401-410. 13. Coster DJ, McKinnon JR, McGill JI, et al: Clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of corneal ulcers caused by herpes simplex virus . J Infect Dis 133( (suppl) ):173-177, 1976.Crossref 14. McGill J, Holt-Wilson AD, McKinnon JR, et al: Some aspects of the clinical use of trifluorothymidine in the treatment of herpetic ulceration of the cornea . Trans Ophthalmol Soc UK 94:342-352, 1974. 15. Jones BR, McGill JI, McKinnon Jr, et al: Preliminary experience with adenine arabinoside in comparison with idoxuridine and trifluorothymidine in the management of herpetic keratitis , in Pavan-Langston D, Buchanan RAH, Alford CH Jr (eds): Adenine Arabinoside: An Antiviral Agent . Raven Press, New York, 1975 pp 411-416. 16. McGill J, Fraunfelder FT, Jones BR: Current and proposed management of ocular herpes simplex . Surv Ophthalmol 20:358-365, 1976.Crossref 17. Hyndiuk RA, Seideman S, Leibsohn JM: Treatment of vaccinial keratitis with trifluorothymidine . Arch Ophthalmol 94:1785-1786, 1976.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Oct 1, 1978

References