Abstract Trichoepithelioma is an uncommon, benign, often multiple tumor of the skin which is frequently hereditary and usually begins during puberty. Although many cases are somewhat cosmetically disfiguring, they usually result in no other physical handicap. The case presented here demonstrates a most severe form of the disease in which the patient's already compromised vision was further reduced by the physical obstruction from the large tumors. Report of Case This 67-year-old white female first noted the occurrence of small multiple skin tumors on her face, neck, back, and ears about the age of 12 years. These slowly increased in size and number during her life, but not until the past 15 years did these tumors become large enough to become quite disfiguring. She was first seen at the Oklahoma University Medical Center in 1952 at which time clinical diagnoses of lepromatous leprosy or diffuse neurofibromatosis were considered. However, on histopathologic examination References 1. Binkley, G. W., and Johnson, H. H.: Epithelioma Adenoides Cysticum; Basal Cell Nevi, Agenesis of Corpus Callosum and Dental Cysts , Arch Derm Syph 63:73-84, 1951.Crossref 2. Brooke, H. G.: Epithelioma Adenoides Cysticum , Brit J Derm 4:269, 1892. 3. Cockayne, E. A.: Inherited Abnormalities of the Skin and Its Appendages , New York: Oxford University Press, Inc., 1933. 4. Everett, M. A.: Personal communication to the author. 5. Fliegelman, M. T., and Druse, W. T.: Hereditary Multiple Benign Cystic Epithelioma , J Invest Derm 11:189-196, 1948.Crossref 6. Fordyce, J. A.: Multiple Benign Cystic Epithelioma , J Cutan Dis 10:459 ( (Dec) ) 1892. 7. Goldman, H. J.: Multiple Benign Cystic Epithelioma; Report of Ten Cases in One Family , JAMA 115:2,253-2,257, 1940. 8. Gorlin, R., and Goltz, R.: Multiple Nevoid Basal Cell Epithelioma, Jaw Cysts and Bifid Rib , New Eng J Med 908-912 ( (May 5) ) 1960. 9. Howell, J. B., and Caro, M.: Basal Cell Nevus , Arch Derm 79:67-80, 1959.Crossref 10. Jarisch: Zur Lehre von den Hautgeschwülsten , Arch Derm Syph 28:163, 1894.Crossref 11. Keyes: Trichoepithelioma of Eye Lid , Amer J Ophthal 28:189-191, 1945. 12. Lever, W. F.: Histopathology of Skin , ed 3, Philadelphia: J. B. Lippincott, 1961. 13. Lever, W. F.: Benign Tumors of Cutaneous Appendages , Arch Derm Syph 57:679-708, 1948.Crossref 14. Lever, W. F.: Discussion of Fitzpatrick, T. B.: Basal Cell Epithelioma with Trichoepithelioma, New England Derm Soc , Arch Derm 83: 513, 1961. 15. Lever, W. F.: Pathogenesis of Benign Tumors of Cutaneous Appendages and of Basal Cell Epithelioma. II. Basal Cell Epithelioma , Arch Derm Syph 57:709, 1948.Crossref 16. Lund, H. Z.: Tumors of the Skin AFIP Atlas of Tumor Pathology, Section 1, Fascicle 2. 17. Mescou, H.: Discussion of Fitzpatrick, T. B.: Basal Cell Epithelioma with Trichoepithelioma, New England Derm Soc , Arch Derm 83: 512-513, 1961.Crossref 18. Peterson, W., and Gorlin, R.: Possible Analogous Cutaneous and Odontogenic Tumors , Arch Derm 90:255-261, 1964.Crossref 19. Ricker, C., and Schwalb, J.: Die Geschwülste der Hautdrüsen , Berlin: S. Karger, 1914, p 23. 20. Savatard, L.: Epithelioma Adenoides Cysticum , Brit J Derm 50:333, 1938.Crossref 21. Summerill, F., and Hutton, J. G.: Multiple Benign Cystic Epithelioma (Epithelioma Adenoides Cysticum) With Summary of Literature , Arch Derm Syph 26:854-864, 1932.Crossref 22. Sutton, R. L.: Differential Study of Multiple Benign Cystic Epithelioma and Adenoma Sebaceum in Negro , J Cutan Dis 29:480, 1911. 23. Traenkle, H. L.: Epithelioma Adenoides Cysticum, Trichoepithelioma and Basal Cell Cancer , Arch Derm Syph 42:822, 1940.Crossref
Archives of Ophthalmology – American Medical Association
Published: Jul 1, 1965
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