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Treatment of Vitiligo With Topical Methoxsalen and Blacklite

Treatment of Vitiligo With Topical Methoxsalen and Blacklite Abstract Fourteen of 15 vitiligo patients responded to the topical use of methoxsalen and subsequent exposure to long-wave ultraviolet light. Three of the subjects showed complete repigmentation. Adverse reactions were prevented by using a controlled energy source with a light emission pattern corresponding to the biologic action spectrum of the photosensitizer. As a delayed 48 to 72 hour erythema was produced, only weekly treatments were necessary. Repigmentation began after two to ten treatments and migrated out from the hair follicles or advanced in from the borders of the vitiliginous areas. This repigmentation was associated with the migration of Dopa-positive melanocytes into the treated areas. References 1. Lerner, A.B.; Denton, C.A.; and Fitzpatrick, T.B.: Clinical and Experimental Studies With 8-Methoxypsoralen in Vitiligo , J Invest Derm 20:299-313 ( (April) ) 1953. 2. Kanoff, N.B.: Melanin Formation in Vitiliginous Skin Under the External Influence of External Applications of 8-Methoxypsoralen , J Invest Derm 24:5-9 ( (Jan) ) 1955. 3. Fitzpatrick, T.B., et al: Hydroquinone and Psoralens in the Therapy of Hypermelanosis and Vitiligo , Arch Derm 93:589-598 ( (May) ) 1966.Crossref 4. Elliot, J.A.: Methoxsalen in the Treatment of Vitiligo , Arch Derm 79:237-241 ( (Feb) ) 1959.Crossref 5. Kelly, E., and Pinkus, H.: Local Application of 8-Methoxypsoralen in Vitiligo , J Invest Derm 25:453-456 ( (Dec) ) 1955.Crossref 6. Buck, H.W.; Magnus, I.A.; and Porter, A.D.: The Action Spectrum of 8-Methoxypsoralen for Erythema in Human Skin , Brit J Derm 72:249-255 ( (July) ) 1960.Crossref 7. Pathak, M.A., and Fellman, J.H.: Activating and Fluorescent Wave-lengths of Furocoumarins: Psoralens , Nature 185:382-383 ( (Feb) ) 1960.Crossref 8. Pathak, M.A.: Mechanism of Psoralen Photosensitization and in vivo Biological Action Spectrum of 8-Methoxypsoralen , J Invest Derm 37:397-407 ( (Nov) ) 1962.Crossref 9. Becker, W.S.: Psoralen Pathotherapeutic Agents , JAMA 202:422-424 ( (Oct 30) ) 1967.Crossref 10. Stegmair, O.C.: The Use of Methoxsalen in Sun Tanning , J Invest Derm 32:345 ( (Feb) ) 1959.Crossref 11. Papa, C.M., and Kligman, A.M.: The Behavior of Melanocytes in Inflammation , J Invest Derm 45:465-474 ( (Dec) ) 1965.Crossref 12. Breathnach, A.S.; Bor, S.; and Wyllie, L.M.A.: Electron Microscopy of Peripheral Nerve Terminals and Marginal Melanocytes in Vitiligo , J Invest Derm 47:125-140 ( (Aug) ) 1966.Crossref 13. Hu, F.; Fosnaugh, R.P.; and Lesney, P.F.: In Vitro Studies on Vitiligo , J Invest Derm 33:267-279 ( (Nov) ) 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Treatment of Vitiligo With Topical Methoxsalen and Blacklite

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1969.01610260100019
Publisher site
See Article on Publisher Site

Abstract

Abstract Fourteen of 15 vitiligo patients responded to the topical use of methoxsalen and subsequent exposure to long-wave ultraviolet light. Three of the subjects showed complete repigmentation. Adverse reactions were prevented by using a controlled energy source with a light emission pattern corresponding to the biologic action spectrum of the photosensitizer. As a delayed 48 to 72 hour erythema was produced, only weekly treatments were necessary. Repigmentation began after two to ten treatments and migrated out from the hair follicles or advanced in from the borders of the vitiliginous areas. This repigmentation was associated with the migration of Dopa-positive melanocytes into the treated areas. References 1. Lerner, A.B.; Denton, C.A.; and Fitzpatrick, T.B.: Clinical and Experimental Studies With 8-Methoxypsoralen in Vitiligo , J Invest Derm 20:299-313 ( (April) ) 1953. 2. Kanoff, N.B.: Melanin Formation in Vitiliginous Skin Under the External Influence of External Applications of 8-Methoxypsoralen , J Invest Derm 24:5-9 ( (Jan) ) 1955. 3. Fitzpatrick, T.B., et al: Hydroquinone and Psoralens in the Therapy of Hypermelanosis and Vitiligo , Arch Derm 93:589-598 ( (May) ) 1966.Crossref 4. Elliot, J.A.: Methoxsalen in the Treatment of Vitiligo , Arch Derm 79:237-241 ( (Feb) ) 1959.Crossref 5. Kelly, E., and Pinkus, H.: Local Application of 8-Methoxypsoralen in Vitiligo , J Invest Derm 25:453-456 ( (Dec) ) 1955.Crossref 6. Buck, H.W.; Magnus, I.A.; and Porter, A.D.: The Action Spectrum of 8-Methoxypsoralen for Erythema in Human Skin , Brit J Derm 72:249-255 ( (July) ) 1960.Crossref 7. Pathak, M.A., and Fellman, J.H.: Activating and Fluorescent Wave-lengths of Furocoumarins: Psoralens , Nature 185:382-383 ( (Feb) ) 1960.Crossref 8. Pathak, M.A.: Mechanism of Psoralen Photosensitization and in vivo Biological Action Spectrum of 8-Methoxypsoralen , J Invest Derm 37:397-407 ( (Nov) ) 1962.Crossref 9. Becker, W.S.: Psoralen Pathotherapeutic Agents , JAMA 202:422-424 ( (Oct 30) ) 1967.Crossref 10. Stegmair, O.C.: The Use of Methoxsalen in Sun Tanning , J Invest Derm 32:345 ( (Feb) ) 1959.Crossref 11. Papa, C.M., and Kligman, A.M.: The Behavior of Melanocytes in Inflammation , J Invest Derm 45:465-474 ( (Dec) ) 1965.Crossref 12. Breathnach, A.S.; Bor, S.; and Wyllie, L.M.A.: Electron Microscopy of Peripheral Nerve Terminals and Marginal Melanocytes in Vitiligo , J Invest Derm 47:125-140 ( (Aug) ) 1966.Crossref 13. Hu, F.; Fosnaugh, R.P.; and Lesney, P.F.: In Vitro Studies on Vitiligo , J Invest Derm 33:267-279 ( (Nov) ) 1959.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1969

References