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TREATMENT OF TUBERCULOUS MENINGITIS

TREATMENT OF TUBERCULOUS MENINGITIS THIS REPORT presents the results of the treatment of two series of infants and children with tuberculous meningitis. The first, consisting of 19 patients, was treated from May, 1947, to February, 1952, with use of a regimen of intramuscular and intrathecal streptomycin, plus oral paraaminosalicylic acid and/or thiazolsulfone (Promizole). The current series of six patients has been treated since May, 1952, with the use of a regimen of intramuscular streptomycin and oral paraaminosalicylic acid and isoniazid, without intrathecal streptomycin. Serum and cerebrospinal fluid isoniazid levels and other laboratory studies are included for the first three patients of the second series and for a fourth patient with only miliary tuberculosis, who served as a control. Success in the treatment of tuberculous meningitis has been attained by various regimens. Lincoln and co-workers,1 in 1948, reported one of the most favorable early series, with six surviving out of seven patients, using intramuscular http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1954.02050090261002
Publisher site
See Article on Publisher Site

Abstract

THIS REPORT presents the results of the treatment of two series of infants and children with tuberculous meningitis. The first, consisting of 19 patients, was treated from May, 1947, to February, 1952, with use of a regimen of intramuscular and intrathecal streptomycin, plus oral paraaminosalicylic acid and/or thiazolsulfone (Promizole). The current series of six patients has been treated since May, 1952, with the use of a regimen of intramuscular streptomycin and oral paraaminosalicylic acid and isoniazid, without intrathecal streptomycin. Serum and cerebrospinal fluid isoniazid levels and other laboratory studies are included for the first three patients of the second series and for a fourth patient with only miliary tuberculosis, who served as a control. Success in the treatment of tuberculous meningitis has been attained by various regimens. Lincoln and co-workers,1 in 1948, reported one of the most favorable early series, with six surviving out of seven patients, using intramuscular

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Mar 1, 1954

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