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Treatment of Traumatic War Neurosis With Phenelzine

Treatment of Traumatic War Neurosis With Phenelzine Abstract • Traumatic war neurosis may become a chronic, debilitating condition that resists treatment interventions. Five patients with traumatic war neurosis had favorable therapeutic responses to phenelzine sulfate. These patients did not respond to multiple previous therapeutic trials with antipsychotics, tricyclic antidepressants, and psychotherapy with or without medication. With phenelzine, the patients felt calmer and stopped having nightmares and flashbacks of traumatic war material. Startle reactions and aggressive, violent outbursts also ceased. References 1. Kardiner A: War Stress and Neurotic Illness . New York, Paul B Hoeber Inc, 1947. 2. Archibald HC, Lang DM, Miller C, et al: Gross stress reaction in combat: A 15-year follow-up . Am J Psychiatry 111:317-322, 1962. 3. Archibald HC, Tuddenham RD: Persistent stress reaction after combat: A 20-year follow-up . Arch Gen Psychiatry 12:475-481, 1965.Crossref 4. Van Putten T, Emory WH: Traumatic neuroses in Vietnam returnees: A forgotten diagnosis? Arch Gen Psychiatry 29:695-698, 1973.Crossref 5. Doobs D, Wilson WP: Observations on persistence of war neurosis . Dis Nerv Syst 21:686-691, 1960. 6. Leahy MR, Martin ICA: Successful hypnotic abreaction after 20 years . Br J Psychiatry 113:383-385, 1967.Crossref 7. Little JC, James B: Abreaction of conditioned fear reaction after 18 years . Behav Res Ther 2:59-63, 1964.Crossref 8. Grinker RR, Spiegel JP: Men Under Stress . New York, McGraw-Hill Book Co, 1963. 9. Glass A: Introduction , in Bourne P (ed): the Psychology and Physiology of Stress With Reference to Special Studies of the Viet Nam War . New York, Academic Press Inc, 1969, pp xiv-xxx. 10. Robinson DS, Nies A, Ravaris CL, et al: Clinical pharmacology of phenelzine . Arch Gen Psychiatry 35:629-635, 1978.Crossref 11. West ED, Dally PJ: Effects of iproniazid in depressive syndromes . Br Med J 1:1491-1494, 1959.Crossref 12. Sargant W, Dally PJ: Treatment of anxiety states by antidepressant drugs . Br Med J 1:6-9, 1962.Crossref 13. Tyrer P, Candy J, Kelly D: Phenelzine in phobic anxiety: A controlled trial . Psychol Med 3:120-124, 1973.Crossref 14. Klein DF: Psychopharmacologic treatment and delineation of borderline disorders , in Hortocollis P (ed): Borderline Personality Disorders: The Concept, The Syndrome, The Patient . New York, International Universities Press Inc, 1977, pp 365-383. 15. Klein DF, Davis JM: Dia&osis and Drug Treatment of Psychiatric Disorders . Baltimore, Williams'& Wilkins Co, 1969, pp 308-309. 16. Robinson DS, Nies A, Ravaris CL, et al: The monoamine oxidase inhibitor, phenelzine, in the treatment of depressive anxiety states: A controlled clinical trial . Arch Gen Psychiatry 29:407-413, 1973.Crossref 17. Klein DF: Delineation of two drug-responsive anxiety syndromes . Psychopharmacologia 5:397-408, 1964.Crossref 18. Wyatt RJ, Kupfer DJ, Snyder F: Total prolonged drug-induced REM sleep suppression in anxious-depressed patients . Arch Gen Psychiatry 24:145-155, 1971.Crossref 19. Dunleavy DLF, Oswald I: Phenelzine, mood response, and sleep . Arch Gen Psychiatry 28:353-356, 1973.Crossref 20. Fisher C: Experimental and clinical approaches to the mind-body problem through recent research in sleep and dreaming , in Rosenzweig N, Griscom H (eds): Psychopharmacology and Psychotherapy: Synthesis or Antithesis? New York, Human Sciences Press, 1978, pp 61-69. 21. Fisher C, Kahn E, Edwards A, et al: A psychophysiological study of nightmares and night terrors . J Nerv Ment Dis 157:75-98, 1973.Crossref 22. Greenberg R, Pearlman CA, Gampel D: War neuroses and the adaptive function of REM sleep . Br J Med Psychol 45:27-33, 1972.Crossref 23. Lavie P, Hefez A, Halperin G, et al: Long-term effects of traumatic war-related events on sleep . Am J Psychiatry 136:175-178, 1979. 24. Kleitman N: Sleep and Wakefulness . Chicago, University of Chicago Press, 1963. 25. Friedman S, Fisher C: On the presence of a rhythmic diurnal, oral instinctual drive cycle in man . J Am Psychoanal Assoc 15:317-343, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Treatment of Traumatic War Neurosis With Phenelzine

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1981.01780290074008
Publisher site
See Article on Publisher Site

Abstract

Abstract • Traumatic war neurosis may become a chronic, debilitating condition that resists treatment interventions. Five patients with traumatic war neurosis had favorable therapeutic responses to phenelzine sulfate. These patients did not respond to multiple previous therapeutic trials with antipsychotics, tricyclic antidepressants, and psychotherapy with or without medication. With phenelzine, the patients felt calmer and stopped having nightmares and flashbacks of traumatic war material. Startle reactions and aggressive, violent outbursts also ceased. References 1. Kardiner A: War Stress and Neurotic Illness . New York, Paul B Hoeber Inc, 1947. 2. Archibald HC, Lang DM, Miller C, et al: Gross stress reaction in combat: A 15-year follow-up . Am J Psychiatry 111:317-322, 1962. 3. Archibald HC, Tuddenham RD: Persistent stress reaction after combat: A 20-year follow-up . Arch Gen Psychiatry 12:475-481, 1965.Crossref 4. Van Putten T, Emory WH: Traumatic neuroses in Vietnam returnees: A forgotten diagnosis? Arch Gen Psychiatry 29:695-698, 1973.Crossref 5. Doobs D, Wilson WP: Observations on persistence of war neurosis . Dis Nerv Syst 21:686-691, 1960. 6. Leahy MR, Martin ICA: Successful hypnotic abreaction after 20 years . Br J Psychiatry 113:383-385, 1967.Crossref 7. Little JC, James B: Abreaction of conditioned fear reaction after 18 years . Behav Res Ther 2:59-63, 1964.Crossref 8. Grinker RR, Spiegel JP: Men Under Stress . New York, McGraw-Hill Book Co, 1963. 9. Glass A: Introduction , in Bourne P (ed): the Psychology and Physiology of Stress With Reference to Special Studies of the Viet Nam War . New York, Academic Press Inc, 1969, pp xiv-xxx. 10. Robinson DS, Nies A, Ravaris CL, et al: Clinical pharmacology of phenelzine . Arch Gen Psychiatry 35:629-635, 1978.Crossref 11. West ED, Dally PJ: Effects of iproniazid in depressive syndromes . Br Med J 1:1491-1494, 1959.Crossref 12. Sargant W, Dally PJ: Treatment of anxiety states by antidepressant drugs . Br Med J 1:6-9, 1962.Crossref 13. Tyrer P, Candy J, Kelly D: Phenelzine in phobic anxiety: A controlled trial . Psychol Med 3:120-124, 1973.Crossref 14. Klein DF: Psychopharmacologic treatment and delineation of borderline disorders , in Hortocollis P (ed): Borderline Personality Disorders: The Concept, The Syndrome, The Patient . New York, International Universities Press Inc, 1977, pp 365-383. 15. Klein DF, Davis JM: Dia&osis and Drug Treatment of Psychiatric Disorders . Baltimore, Williams'& Wilkins Co, 1969, pp 308-309. 16. Robinson DS, Nies A, Ravaris CL, et al: The monoamine oxidase inhibitor, phenelzine, in the treatment of depressive anxiety states: A controlled clinical trial . Arch Gen Psychiatry 29:407-413, 1973.Crossref 17. Klein DF: Delineation of two drug-responsive anxiety syndromes . Psychopharmacologia 5:397-408, 1964.Crossref 18. Wyatt RJ, Kupfer DJ, Snyder F: Total prolonged drug-induced REM sleep suppression in anxious-depressed patients . Arch Gen Psychiatry 24:145-155, 1971.Crossref 19. Dunleavy DLF, Oswald I: Phenelzine, mood response, and sleep . Arch Gen Psychiatry 28:353-356, 1973.Crossref 20. Fisher C: Experimental and clinical approaches to the mind-body problem through recent research in sleep and dreaming , in Rosenzweig N, Griscom H (eds): Psychopharmacology and Psychotherapy: Synthesis or Antithesis? New York, Human Sciences Press, 1978, pp 61-69. 21. Fisher C, Kahn E, Edwards A, et al: A psychophysiological study of nightmares and night terrors . J Nerv Ment Dis 157:75-98, 1973.Crossref 22. Greenberg R, Pearlman CA, Gampel D: War neuroses and the adaptive function of REM sleep . Br J Med Psychol 45:27-33, 1972.Crossref 23. Lavie P, Hefez A, Halperin G, et al: Long-term effects of traumatic war-related events on sleep . Am J Psychiatry 136:175-178, 1979. 24. Kleitman N: Sleep and Wakefulness . Chicago, University of Chicago Press, 1963. 25. Friedman S, Fisher C: On the presence of a rhythmic diurnal, oral instinctual drive cycle in man . J Am Psychoanal Assoc 15:317-343, 1967.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Apr 1, 1981

References