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Orr Hc (1936)
ACETYLCHOLINE IN TOBACCO AMBLYOPIA.BMJ, 2
F. Carroll (1935)
ANALYSIS OF FIFTY-FIVE CASES OF TOBACCO-ALCOHOL AMBLYOPIAArchives of Ophthalmology, 14
W. Duggan (1937)
ACETYLCHOLINE IN THE TREATMENT OF ACUTE RETROBULBAR NEURITISArchives of Ophthalmology, 17
In a recent article,1 evidence was outlined for the hypothesis that tobacco amblyopia is due to a vascular spasm in the visual pathway. This etiology was suggested by A. Maitland Ramsay prior to 1896 and later by Parsons, Aubaret and Sedan, Scalinci, Farnarier and others. In 1930 Pflimlin2 reported fifteen cases in which toxic amblyopia was treated with intravenous injections of sodium nitrite twice weekly for from three to eleven weeks. Eleven patients (73.3 per cent) attained vision of 6/12 or better in one or both eyes in an average time of thirty-six days, and seven patients (46.6 per cent) attained vision of 6/6 in one or both eyes in approximately the same average time. This was the first report to appear in the literature of the systematic use of vasodilators in the treatment of this disease. It was Pflimlin's impression that with abstinence alone a year would
JAMA – American Medical Association
Published: Oct 23, 1937
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