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TREATMENT OF SYPHILIS WITH PHENARSINE HYDROCHLORIDE: PRELIMINARY REPORT

TREATMENT OF SYPHILIS WITH PHENARSINE HYDROCHLORIDE: PRELIMINARY REPORT Abstract The therapeutic efficiency of any arsenical preparation for the treatment of syphilis is judged largely from the response of early syphilis (primary and secondary) to its use. In order to evaluate a new drug the most important factors to consider are: (1) the rapid control of infectiousness, (2) the healing of lesions, (3) the rate and permanence of serologic response, (4) the prevention of infectious or serologic relapse and progression of the disease, (5) low incidence of involvement of the central nervous system in early syphilis, (6) a beneficial effect on late syphilis and (7) a low incidence of untoward or toxic reactions. A drug which would meet these requirements would indeed be ideal. Arsphenamine is, even today, the most active of the arsenical preparations in common use, and yet, because of the difficulties encountered in its administration and its untoward effects, it has been largely replaced by drugs which References 1. Tatum, A. L., and Cooper, G. A.: An Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as an Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198 ( (Feb.) ) 1934. 2. Foerster, O. H.; McIntosh, R. L.; Weider, L. M.; Foerster, L. M., and Cooper, G. A.: Mapharsen in the Treatment of syphilis , Arch. Dermat. & Syph. 32:868 ( (Dec.) ) 1935. 3. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirillosen , Berlin, Julius Springer, 1910. 4. Stokes, J. H.; Beerman, H., and Ingrem, N. R., Jr.: The Trivalent Arsenicals in Syphilis , Am. J. M. Sc. 201:611 ( (April) ) 1941. 5. Tompsett, R. R.; Downs, W. G.; McDermott, W., and Webster, B.: The Use of Clorarsen in the Treatment of Syphilis , J. Pharmacol. & Exper. Therap. 73:412 ( (Dec.) ) 1941. 6. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C Thomas, Publisher, 1941, chap. 31 , p. 346. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

TREATMENT OF SYPHILIS WITH PHENARSINE HYDROCHLORIDE: PRELIMINARY REPORT

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Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1943.01500200070006
Publisher site
See Article on Publisher Site

Abstract

Abstract The therapeutic efficiency of any arsenical preparation for the treatment of syphilis is judged largely from the response of early syphilis (primary and secondary) to its use. In order to evaluate a new drug the most important factors to consider are: (1) the rapid control of infectiousness, (2) the healing of lesions, (3) the rate and permanence of serologic response, (4) the prevention of infectious or serologic relapse and progression of the disease, (5) low incidence of involvement of the central nervous system in early syphilis, (6) a beneficial effect on late syphilis and (7) a low incidence of untoward or toxic reactions. A drug which would meet these requirements would indeed be ideal. Arsphenamine is, even today, the most active of the arsenical preparations in common use, and yet, because of the difficulties encountered in its administration and its untoward effects, it has been largely replaced by drugs which References 1. Tatum, A. L., and Cooper, G. A.: An Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as an Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198 ( (Feb.) ) 1934. 2. Foerster, O. H.; McIntosh, R. L.; Weider, L. M.; Foerster, L. M., and Cooper, G. A.: Mapharsen in the Treatment of syphilis , Arch. Dermat. & Syph. 32:868 ( (Dec.) ) 1935. 3. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirillosen , Berlin, Julius Springer, 1910. 4. Stokes, J. H.; Beerman, H., and Ingrem, N. R., Jr.: The Trivalent Arsenicals in Syphilis , Am. J. M. Sc. 201:611 ( (April) ) 1941. 5. Tompsett, R. R.; Downs, W. G.; McDermott, W., and Webster, B.: The Use of Clorarsen in the Treatment of Syphilis , J. Pharmacol. & Exper. Therap. 73:412 ( (Dec.) ) 1941. 6. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C Thomas, Publisher, 1941, chap. 31 , p. 346.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Feb 1, 1943

References