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Abstract • Twenty-one episodes of status epilepticus (SE) were each treated with 1 to 9 mg (mean, 4 mg) of intravenous lorazepam. All patients with generalized tonicclonic (GTC) SE responded within 15 minutes. Nine (82%) of the 11 patients with episodes of partial SE with altered responsiveness responded poorly. Respiratory depression occurred in five instances (two requiring intubation) and was associated with transient loss of brain-stem reflexes, hypotension, and decorticate posturing in three cases. Generalized tonic-clonic SE was transformed into partial SE with altered responsiveness in three patients. In an additional four patients, marked lethargy developed. Lorazepam appears effective in controlling GTC SE but only occasionally effective in partial SE with altered responsiveness. References 1. Delgado-Escueta AV, Bajorek JG: Status epilepticus: Mechanisms of brain damage and rational management . Epilepsia 1982;23( (suppl 1) ):S29-S41.Crossref 2. 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Drugs 1981;21:161-200.Crossref 25. Cormack RS, Milledge JS, Hanning CD: Respiratory effects and amnesia after premedication with morphine or lorazepam . Br J Anaesth 1977;49:351-361.Crossref 26. Elliott HW, Nomof N, Navarro G, et al: Central nervous system and cardiovascular effects of lorazepam in man . Clin Pharmacol Ther 1971;12:468-481. 27. Denaut M, Yernault JC, DeCoster A: Double-blind comparison of the respiratory effects of parenteral lorazepam and diazepam in patients with chronic obstructive lung disease . Curr Med Res Opin 1975;2:611-615.Crossref 28. Guerrero-Figueroa R, Guerrero-Figueroa E, Sneed GA, et al: Effects of lorazepam on CNS structures: Neurophysiological and behavioral correlations . Curr Ther Res 1974;16:137-146. 29. Browne TR, Penry JK: Benzodiazepines in the treatment of epilepsy . Epilepsia 1973;14:277-310.Crossref 30. Jaffe R, Christoff NJ: Intravenous diazepam in seizure disorders . Electroencephalogr Clin Neurophysiol 1967;23:77-97.Crossref 31. 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Archives of Neurology – American Medical Association
Published: Jun 1, 1984
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