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Treatment of Some Dermatoses by Local Injection of Vitamin A: Histologic Effect on Human Epidermis: Effective Treatment of Plantar Warts

Treatment of Some Dermatoses by Local Injection of Vitamin A: Histologic Effect on Human... Abstract Despite a voluminous literature on the role of vitamin A in the biochemistry of the skin there are few reports of histologic studies of human epidermis after local injection of vitamin A and the effect of local injections in treatment of certain dermatoses. These considerations are the purpose of this study. Methods and Materials A commercial vitamin A palmitate solution (Keramin)* especially formulated for injection of cutaneous lesions was employed. This solution has an activity of 50,000 U.S.P. units per cubic centimeter in a vehicle consisting of 11% polysorbate 80, U.S.P. (solubilizing agent), 0.4% dl-alpha-tocopherol, N.F., 0.03% butylatedhydroxyanisole, and 0.5% chlorobutanol, U.S.P., (preservative and antioxidants). A sterile solution containing all ingredients except vitamin A was used for control injection. Effect on Normal Human Epidermis.— The normal skin of two persons was injected intracutaneously with Keramin 0.1 cc. At another site 0.1 cc. of the control solution was injected. These injections References 1. Keramin and control solution were supplied by Campbell Pharmaceuticals, Inc., New York. 2. Kuhn, B. H.: Combined Systemic and Local Treatment of Warts , South. M.J. 52:211 ( (Feb.) ) 1959.Crossref 3. Steinberg, M. D.: A New Treatment for Resistant Warts , Surgery 39:642 ( (April) ) 1956. 4. Gilbert, R. S., and Williams, M. J.: Local Injection of Vitamin A (Keramin) for Plantar Verruca , U.S. Armed Forces M.J. 10:843 ( (July) ) 1959. 5. Lehman, R. A., and Manning, M. M.: Treatment of Plantar Warts by Local Injection of Vitamin A , Clin. Med. 6:1153 ( (July) ) 1959. 6. Lyell, A., and Myles, J. A. R.: Myrmecia: A Study of Inclusion Bodies of Warts , Brit. M.J. 1:912 ( (April) ) 1951.Crossref 7. Silverman, A. H.; Arancia, L. J., and Steiner, J. W.: The Place of an Intradermal Vitamin A Injection in the Routine Management of Helomata , J. Am. Podiatry Assoc. 48:408 ( (Sept.) ) 1958. 8. Straumfjord, J. V.: Lesions of Vitamin A Deficiency: Their Local Character and Chronicity , Northwest. Med. 41:229 ( (July) ) 1942. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Treatment of Some Dermatoses by Local Injection of Vitamin A: Histologic Effect on Human Epidermis: Effective Treatment of Plantar Warts

A.M.A. Archives of Dermatology , Volume 81 (2) – Feb 1, 1960

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730020089014
Publisher site
See Article on Publisher Site

Abstract

Abstract Despite a voluminous literature on the role of vitamin A in the biochemistry of the skin there are few reports of histologic studies of human epidermis after local injection of vitamin A and the effect of local injections in treatment of certain dermatoses. These considerations are the purpose of this study. Methods and Materials A commercial vitamin A palmitate solution (Keramin)* especially formulated for injection of cutaneous lesions was employed. This solution has an activity of 50,000 U.S.P. units per cubic centimeter in a vehicle consisting of 11% polysorbate 80, U.S.P. (solubilizing agent), 0.4% dl-alpha-tocopherol, N.F., 0.03% butylatedhydroxyanisole, and 0.5% chlorobutanol, U.S.P., (preservative and antioxidants). A sterile solution containing all ingredients except vitamin A was used for control injection. Effect on Normal Human Epidermis.— The normal skin of two persons was injected intracutaneously with Keramin 0.1 cc. At another site 0.1 cc. of the control solution was injected. These injections References 1. Keramin and control solution were supplied by Campbell Pharmaceuticals, Inc., New York. 2. Kuhn, B. H.: Combined Systemic and Local Treatment of Warts , South. M.J. 52:211 ( (Feb.) ) 1959.Crossref 3. Steinberg, M. D.: A New Treatment for Resistant Warts , Surgery 39:642 ( (April) ) 1956. 4. Gilbert, R. S., and Williams, M. J.: Local Injection of Vitamin A (Keramin) for Plantar Verruca , U.S. Armed Forces M.J. 10:843 ( (July) ) 1959. 5. Lehman, R. A., and Manning, M. M.: Treatment of Plantar Warts by Local Injection of Vitamin A , Clin. Med. 6:1153 ( (July) ) 1959. 6. Lyell, A., and Myles, J. A. R.: Myrmecia: A Study of Inclusion Bodies of Warts , Brit. M.J. 1:912 ( (April) ) 1951.Crossref 7. Silverman, A. H.; Arancia, L. J., and Steiner, J. W.: The Place of an Intradermal Vitamin A Injection in the Routine Management of Helomata , J. Am. Podiatry Assoc. 48:408 ( (Sept.) ) 1958. 8. Straumfjord, J. V.: Lesions of Vitamin A Deficiency: Their Local Character and Chronicity , Northwest. Med. 41:229 ( (July) ) 1942.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1960

References