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Treatment of Severe Cutaneous Small-Vessel Vasculitis With Mycophenolate Mofetil

Treatment of Severe Cutaneous Small-Vessel Vasculitis With Mycophenolate Mofetil THE CUTTING EDGE: CHALLENGES IN MEDICAL AND SURGICAL THERAPIES SECTION EDITOR: EDWARD W. COWEN, MD, MHSc; ASSISTANT SECTION EDITORS: MURAD ALAM, MD; RUTH ANN VLEUGELS, MD Treatment of Severe Cutaneous Small-Vessel Vasculitis With Mycophenolate Mofetil M. Tye Haeberle, MD; William B. Adams, MD; Jeffrey P. Callen, MD; Division of Dermatology, Department of Medicine (Drs Adams and Callen), University of Louisville School of Medicine (Dr Haeberle), Louisville, Kentucky. Antineutrophilic cytoplasmic antibody (ANCA)-negative, or serum protein electrophoresis. Serologic findings were cutaneous,small-vesselvasculitis(CSVV)isawell-described negative for cryoglobulins; ANCA; and anti-Smith, anti- disease with a variety of treatment options. Mycophenolate Scl-70, anti-Ro (SS-A), anti-La (SS-B), antihistone, anti– mofetil (MMF) is an often-used immunosuppressive drug Jo-1, and anticentromeric antibodies. Urinalysis find- forinflammatoryailments.Hereinwedescribethefirstcase ings were positive for 2 blood, 2 protein, and 11 to 30 of ANCA-negative CSVV treated successfully with MMF. red blood cells per high-powered field, consistent with the microscopic hematuria in the patient’s history. Find- ings of direct immunofluorescence studies of a biopsy REPORT OF A CASE specimen taken from the presumed newest lesion on the left thigh were scantly positive for IgM in blood vessels A 46-year-old man presented with a 5-week history of and negative for IgA and IgG; C3 findings were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Treatment of Severe Cutaneous Small-Vessel Vasculitis With Mycophenolate Mofetil

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archdermatol.2011.3037
pmid
22911181
Publisher site
See Article on Publisher Site

Abstract

THE CUTTING EDGE: CHALLENGES IN MEDICAL AND SURGICAL THERAPIES SECTION EDITOR: EDWARD W. COWEN, MD, MHSc; ASSISTANT SECTION EDITORS: MURAD ALAM, MD; RUTH ANN VLEUGELS, MD Treatment of Severe Cutaneous Small-Vessel Vasculitis With Mycophenolate Mofetil M. Tye Haeberle, MD; William B. Adams, MD; Jeffrey P. Callen, MD; Division of Dermatology, Department of Medicine (Drs Adams and Callen), University of Louisville School of Medicine (Dr Haeberle), Louisville, Kentucky. Antineutrophilic cytoplasmic antibody (ANCA)-negative, or serum protein electrophoresis. Serologic findings were cutaneous,small-vesselvasculitis(CSVV)isawell-described negative for cryoglobulins; ANCA; and anti-Smith, anti- disease with a variety of treatment options. Mycophenolate Scl-70, anti-Ro (SS-A), anti-La (SS-B), antihistone, anti– mofetil (MMF) is an often-used immunosuppressive drug Jo-1, and anticentromeric antibodies. Urinalysis find- forinflammatoryailments.Hereinwedescribethefirstcase ings were positive for 2 blood, 2 protein, and 11 to 30 of ANCA-negative CSVV treated successfully with MMF. red blood cells per high-powered field, consistent with the microscopic hematuria in the patient’s history. Find- ings of direct immunofluorescence studies of a biopsy REPORT OF A CASE specimen taken from the presumed newest lesion on the left thigh were scantly positive for IgM in blood vessels A 46-year-old man presented with a 5-week history of and negative for IgA and IgG; C3 findings were

Journal

JAMA DermatologyAmerican Medical Association

Published: Aug 1, 2012

References