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Treatment of Relapsing Polychondritis With Dapsone

Treatment of Relapsing Polychondritis With Dapsone Abstract • Three patients with relapsing polychondritis were treated successfully with dapsone. Mounting evidence suggests an immune-related pathogenesis for relapsing polychondritis. Dapsone may be effective in certain immune-related diseases because of its inhibition of lysosomal enzymes. (Arch Dermatol 112:1286-1288, 1976) References 1. Jaksch-Wartenhorst R: Polychondropathia . Wier Arch Inn Med 6:93-100, 1923. 2. Dolan DL, Lemmon GB, Teitelbaum SL: Relapsing polychondritis: Analytic literature review and studies on pathogenesis . Am J Med 41:285-299, 1966.Crossref 3. Rogers PH, Boden G, Tourtellotte CD: Relapsing polychondritis with insulin resistance and antibodies to cartilage . Am J Med 55:243-248, 1973.Crossref 4. Rajapakse DA, Bywaters EGL: Relapsing polychondritis and pulseless disease . Br J Med 4:488-489, 1973.Crossref 5. Herman JH, Dennis MV: Immunopathologic studies in relapsing polychondritis . J Clin Invest 52:549-558, 1973.Crossref 6. Thomas L, et al: Comparison of the effects of papain and vitamin A on cartilage: The effect in rabbits . J Exp Med 111:705-718, 1960.Crossref 7. Weissmann G, Dingle J: Release of lysosomal protease by ultra-violet irradiation and inhibition by hydrocortisone . Exp Cell Res 25:207-210, 1961.Crossref 8. Barranco VP: Inhibition of lysosomal enzymes by dapsone . Arch Dermatol 110:563-566, 1974.Crossref 9. Butcher RB, Tabb HG, Dunlap CE: Relapsing polychondritis . South Med Journal 67:1443-1449, 1974.Crossref 10. Glenn LE, Holborrow EJ: Conversion of tissue polysaccharides to autoantigens by group A beta-hemolytic streptococci . Lancet 2:449-451, 1952.Crossref 11. Arundell FW, Haserick JR: Familial chronic atrophic polychondritis . Arch Dermatol 82:439-440, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Treatment of Relapsing Polychondritis With Dapsone

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630330048013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Three patients with relapsing polychondritis were treated successfully with dapsone. Mounting evidence suggests an immune-related pathogenesis for relapsing polychondritis. Dapsone may be effective in certain immune-related diseases because of its inhibition of lysosomal enzymes. (Arch Dermatol 112:1286-1288, 1976) References 1. Jaksch-Wartenhorst R: Polychondropathia . Wier Arch Inn Med 6:93-100, 1923. 2. Dolan DL, Lemmon GB, Teitelbaum SL: Relapsing polychondritis: Analytic literature review and studies on pathogenesis . Am J Med 41:285-299, 1966.Crossref 3. Rogers PH, Boden G, Tourtellotte CD: Relapsing polychondritis with insulin resistance and antibodies to cartilage . Am J Med 55:243-248, 1973.Crossref 4. Rajapakse DA, Bywaters EGL: Relapsing polychondritis and pulseless disease . Br J Med 4:488-489, 1973.Crossref 5. Herman JH, Dennis MV: Immunopathologic studies in relapsing polychondritis . J Clin Invest 52:549-558, 1973.Crossref 6. Thomas L, et al: Comparison of the effects of papain and vitamin A on cartilage: The effect in rabbits . J Exp Med 111:705-718, 1960.Crossref 7. Weissmann G, Dingle J: Release of lysosomal protease by ultra-violet irradiation and inhibition by hydrocortisone . Exp Cell Res 25:207-210, 1961.Crossref 8. Barranco VP: Inhibition of lysosomal enzymes by dapsone . Arch Dermatol 110:563-566, 1974.Crossref 9. Butcher RB, Tabb HG, Dunlap CE: Relapsing polychondritis . South Med Journal 67:1443-1449, 1974.Crossref 10. Glenn LE, Holborrow EJ: Conversion of tissue polysaccharides to autoantigens by group A beta-hemolytic streptococci . Lancet 2:449-451, 1952.Crossref 11. Arundell FW, Haserick JR: Familial chronic atrophic polychondritis . Arch Dermatol 82:439-440, 1960.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1976

References