Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Treatment of Psoriasis With Topically Applied Tretinoin and Steroid Ointment

Treatment of Psoriasis With Topically Applied Tretinoin and Steroid Ointment Abstract The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study. The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees. Irritancy from the high-strength tretinoin was a potentially troublesome sideeffect. Care must be taken to avoid drug contact on areas that are easily irritated. References 1. Von Beer P: Untersuchungen Über die wirkung der Vitamin-A-Säure . Dermatologica 124:192-195, 1962.Crossref 2. Frost P, Weinstein GD: Topical administration of vitamin A acid for ichthyosiform dermatoses and psoriasis . JAMA 207:1863-1868, 1969.Crossref 3. Fry L, Macdonald A, McMinn RMH: Effect of retinoic acid in psoriasis . Br J Dermatol 83:391-396, 1970.Crossref 4. Fredriksson T: Antipsoriatic activity of retinoic acid (vitamin A acid) . Dermatologica 142:133-136, 1971.Crossref 5. Peck GL, Key DJ, Guss SB: Topical vitamin A acid in the treatment of psoriasis . Arch Dermatol 107:245-248, 1973.Crossref 6. Orfanos CE, Schmidt HW, Mahrle G, et al: Retinoic acid in psoriasis: Its value for topical therapy with and without corticosteroids: Clinical, histological and electron microscopical studies on forty-four hospitalized patients with extensive psoriasis . Br J Dermatol 88:167-182, 1973.Crossref 7. Macdonald A, Fry L: Retinoic acid in the treatment of psoriasis . Br J Dermatol 86:524-527, 1972.Crossref 8. Plewig G, Wolff HH, Braum-Falco 0: Lokalbehandlung normaler und pathologischer menschlicher Haut mit Vitamin A-Säure: Klinische, histologische und elektronenmikroskopische Untersuchungen . Arch Klin Exp Dermatol 239:390-413, 1971.Crossref 9. Kaidbey KH, Kligman AM, Yoshida H: Effects of intensive application of retinoic acid on human skin . Br J Dermatol , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Treatment of Psoriasis With Topically Applied Tretinoin and Steroid Ointment

Loading next page...
 
/lp/american-medical-association/treatment-of-psoriasis-with-topically-applied-tretinoin-and-steroid-SAPLpU3LG2
Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1975.01630200061006
Publisher site
See Article on Publisher Site

Abstract

Abstract The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study. The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees. Irritancy from the high-strength tretinoin was a potentially troublesome sideeffect. Care must be taken to avoid drug contact on areas that are easily irritated. References 1. Von Beer P: Untersuchungen Über die wirkung der Vitamin-A-Säure . Dermatologica 124:192-195, 1962.Crossref 2. Frost P, Weinstein GD: Topical administration of vitamin A acid for ichthyosiform dermatoses and psoriasis . JAMA 207:1863-1868, 1969.Crossref 3. Fry L, Macdonald A, McMinn RMH: Effect of retinoic acid in psoriasis . Br J Dermatol 83:391-396, 1970.Crossref 4. Fredriksson T: Antipsoriatic activity of retinoic acid (vitamin A acid) . Dermatologica 142:133-136, 1971.Crossref 5. Peck GL, Key DJ, Guss SB: Topical vitamin A acid in the treatment of psoriasis . Arch Dermatol 107:245-248, 1973.Crossref 6. Orfanos CE, Schmidt HW, Mahrle G, et al: Retinoic acid in psoriasis: Its value for topical therapy with and without corticosteroids: Clinical, histological and electron microscopical studies on forty-four hospitalized patients with extensive psoriasis . Br J Dermatol 88:167-182, 1973.Crossref 7. Macdonald A, Fry L: Retinoic acid in the treatment of psoriasis . Br J Dermatol 86:524-527, 1972.Crossref 8. Plewig G, Wolff HH, Braum-Falco 0: Lokalbehandlung normaler und pathologischer menschlicher Haut mit Vitamin A-Säure: Klinische, histologische und elektronenmikroskopische Untersuchungen . Arch Klin Exp Dermatol 239:390-413, 1971.Crossref 9. Kaidbey KH, Kligman AM, Yoshida H: Effects of intensive application of retinoic acid on human skin . Br J Dermatol , to be published.

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1975

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month