Abstract The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study. The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees. Irritancy from the high-strength tretinoin was a potentially troublesome sideeffect. Care must be taken to avoid drug contact on areas that are easily irritated. References 1. Von Beer P: Untersuchungen Über die wirkung der Vitamin-A-Säure . Dermatologica 124:192-195, 1962.Crossref 2. Frost P, Weinstein GD: Topical administration of vitamin A acid for ichthyosiform dermatoses and psoriasis . JAMA 207:1863-1868, 1969.Crossref 3. Fry L, Macdonald A, McMinn RMH: Effect of retinoic acid in psoriasis . Br J Dermatol 83:391-396, 1970.Crossref 4. Fredriksson T: Antipsoriatic activity of retinoic acid (vitamin A acid) . Dermatologica 142:133-136, 1971.Crossref 5. Peck GL, Key DJ, Guss SB: Topical vitamin A acid in the treatment of psoriasis . Arch Dermatol 107:245-248, 1973.Crossref 6. Orfanos CE, Schmidt HW, Mahrle G, et al: Retinoic acid in psoriasis: Its value for topical therapy with and without corticosteroids: Clinical, histological and electron microscopical studies on forty-four hospitalized patients with extensive psoriasis . Br J Dermatol 88:167-182, 1973.Crossref 7. Macdonald A, Fry L: Retinoic acid in the treatment of psoriasis . Br J Dermatol 86:524-527, 1972.Crossref 8. Plewig G, Wolff HH, Braum-Falco 0: Lokalbehandlung normaler und pathologischer menschlicher Haut mit Vitamin A-Säure: Klinische, histologische und elektronenmikroskopische Untersuchungen . Arch Klin Exp Dermatol 239:390-413, 1971.Crossref 9. Kaidbey KH, Kligman AM, Yoshida H: Effects of intensive application of retinoic acid on human skin . Br J Dermatol , to be published.
Archives of Dermatology – American Medical Association
Published: Aug 1, 1975
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