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Treatment of Patent Ductus Arteriosus With Indomethacin

Treatment of Patent Ductus Arteriosus With Indomethacin Abstract Sir.—In the March issue of AJDC, Ramsay et al1 reported that nine of 19 infants required ductus ligation because of initial treatment failure or relapse after indomethacin administration for a patent ductus arteriosus (PDA). Their treatment regimen with indomethacin consisted of an initial dose of 0.2 mg/kg followed by two doses of 0.1 mg/kg at 12- and 24-hour intervals. Ramsay et al speculated that the success rate of the treatment could be improved by increasing the amount of the first and/or subsequent indomethacin doses. We would like to report our experience with indomethacin given in three doses of 0.2 mg/kg every eight hours. In our unit, PDA is suspected if an infant has consistent clinical signs or cannot be weaned from the ventilator and after the primary cause for administration of mechanical ventilation has resolved. The diagnosis is always confirmed with contrast echocardiography2 or echo-Doppler cardiography. The References 1. Ramsay JM, Murphy DJ, Vick GW III, et al: Response of the patent ductus arteriosus to indomethacin treatment . AJDC 1987;141:294-297. 2. Elzenga NJ, Spritzer R: Countercurrent arterial contrast echocardiography in the assessment of left to right ductal shunting in preterm infants . Arch Dis Child 1984;59:533-536.Crossref 3. Yanagi RM, Wilson A, Newfeld EA, et al: Indomethacin treatment for symptomatic patent ductus arteriosus: A double blind control study . Pediatrics 1981;67:647-652. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Treatment of Patent Ductus Arteriosus With Indomethacin

Treatment of Patent Ductus Arteriosus With Indomethacin

Abstract

Abstract Sir.—In the March issue of AJDC, Ramsay et al1 reported that nine of 19 infants required ductus ligation because of initial treatment failure or relapse after indomethacin administration for a patent ductus arteriosus (PDA). Their treatment regimen with indomethacin consisted of an initial dose of 0.2 mg/kg followed by two doses of 0.1 mg/kg at 12- and 24-hour intervals. Ramsay et al speculated that the success rate of the treatment could be improved by increasing the amount of...
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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1988.02150020020013
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—In the March issue of AJDC, Ramsay et al1 reported that nine of 19 infants required ductus ligation because of initial treatment failure or relapse after indomethacin administration for a patent ductus arteriosus (PDA). Their treatment regimen with indomethacin consisted of an initial dose of 0.2 mg/kg followed by two doses of 0.1 mg/kg at 12- and 24-hour intervals. Ramsay et al speculated that the success rate of the treatment could be improved by increasing the amount of the first and/or subsequent indomethacin doses. We would like to report our experience with indomethacin given in three doses of 0.2 mg/kg every eight hours. In our unit, PDA is suspected if an infant has consistent clinical signs or cannot be weaned from the ventilator and after the primary cause for administration of mechanical ventilation has resolved. The diagnosis is always confirmed with contrast echocardiography2 or echo-Doppler cardiography. The References 1. Ramsay JM, Murphy DJ, Vick GW III, et al: Response of the patent ductus arteriosus to indomethacin treatment . AJDC 1987;141:294-297. 2. Elzenga NJ, Spritzer R: Countercurrent arterial contrast echocardiography in the assessment of left to right ductal shunting in preterm infants . Arch Dis Child 1984;59:533-536.Crossref 3. Yanagi RM, Wilson A, Newfeld EA, et al: Indomethacin treatment for symptomatic patent ductus arteriosus: A double blind control study . Pediatrics 1981;67:647-652.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1988

References