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Treatment of Mumps Orchitis with Adrenal Hormones: Report of Twenty-Three Cases with a Note on Hepatic Involvement in Mumps

Treatment of Mumps Orchitis with Adrenal Hormones: Report of Twenty-Three Cases with a Note on... Abstract Epididymo-orchitis occurs as a complication in the course of mumps in 18% to 43% of postpubertal males.1-4 Not only is gonadal involvement accompanied by severe local pain and systemic discomfort, but testicular atrophy is a sequel in about one-half of the cases, and sterility can result, although this is probably unusual.5,6 Of the various prophylactic measures that have been tried in males with epidemic parotitis, the administration of diethylstilbestrol has given encouraging results,7,8 and early injection of γ-globulin prepared from mumps convalescent serum has resulted in definite reduction in the incidence of orchitis.9 The treatment of established orchitis, however, has remained unsatisfactory. Antibiotics,10-14 pooled plasma,15-17 convalescent serum,18 estrogens,7 and surgical decompression 19-21 have been irregularly effective. At present, the usual regimen consists of analgesic and antipyretic drugs with local application of cold and the use of various suspensory devices. The few available descriptions of the histologie characteristics of mumps orchitis20 References 1. McGuiness, A. C., and Gall, E. A.: Mumps at Army Camps in 1943 , War Med. 5:95-104, 1944. 2. Riley, H. D., Jr.: Complications of Mumps , U. S. Armed Forces M. J. 3:1887-1891, 1952. 3. Greene, J. A., and Heeren, A. H.: Mumps: The Incidence of Palpable Splenic Enlargement and of "Complications," and Their Relation to Salivary Gland Involvement as Evidence that the Disease is a Systemic Infection , J. Lab. & Clin. Med. 23:129-134, 1937. 4. Eagles, A. Y.: Analysis of a 4 Year Epidemic of Mumps , Arch. Int. Med. 80:374-387, 1947. 5. Werner, C. A.: Mumps Orchitis and Testicular Atrophy: II. A Factor in Male Sterility , Ann. Int. Med. 32:1075-1086, 1950. 6. Michelson, L., and Michelson, R. P.: Fertility Studies of the Male in Barren Marriages , J. A. M. A. 134:941-944, 1947. 7. Hoyne, A. L.; Diamond, J. H., and Christian, J. R.: Diethylstilbestrol in Mumps Orchitis: Prophylactic and Therapeutic Use , J. A. M. A. 140:662-665, 1949. 8. Savran, J.: Diethylstilbestrol in the Prevention of Orchitis Following Mumps , Rhode Island M. J. 29:662, 1946. 9. Gellis, S. S.; McGuiness, A. C., and Peters, M.: A Study on the Prevention of Mumps Orchitis by Gamma Globulin , Am. J. M. Sc. 210:661-664, 1945. 10. Sutliff, W. D., and Barnes, Z. B.: Aureomycin, Chloramphenicol, and Oxytetracycline ("Terramycin") in Mumps , A. M. A. Arch. Int. Med. 91:68-77, 1953. 11. Homer, L., and Donovan, W. N.: Aureomycin in Mumps , J. A. M. A. 150:465-467, 1952. 12. Redewill, F. H.: Chloromycetin in the Successful Treatment of Recurring Epididymitis , J. Urol. 62:581-589, 1949. 13. Spinelli, N. P. R.; Cressy, N. L., and Kunkel, P.: Aureomycin in the Treatment of Mumps Orchitis and Encephalitis , Connecticut M. J. 15: 113-116, 1951. 14. Sayer, R. J.; Michel, J. C.; Moll, F. C., and Kirby, W. M. M.: Terramycin: Clinical, Pharmacologic, and Bacteriologic Studies , Am. J. M. Sc. 221:256-263, 1951. 15. Smith, R. S.: Plasma Treatment of Mumps Orchitis , U. S. Nav. M. Bull. 44:159-160, 1945. 16. Huie, R. E., Jr.: Mumps Orchitis Treated with Reactivated Pooled Plasma: Report of 5 Cases , U. S. Nav. M. Bull. 48:897-900, 1948. 17. Rambar, A. C.: Pooled Plasma Treatment of Mumps Orchitis , U. S. Nav. M. Bull. 42:871-873, 1944. 18. Rambar, A. C.: Mumps: Use of Convalescent Serum in the Treatment and Prophylaxis of Orchitis , Am. J. Dis. Child. 71:1-13, 1946. 19. Finn, H. G., and Palmberg, K. J.: Surgical Treatment of Severe Mumps Orchitis , U. S. Nav. M. Bull. 42:1388-1390, 1944. 20. Smith, G. G.: Two Cases of Orchitis Due to Mumps Treated by Operation , Boston M. & S. J. 167:323-325, 1912. 21. Wesselhoeft, C., and Vose, S. N.: Surgical Treatment of Severe Orchitis in Mumps , N. England J. Med. 227:277-280, 1942.Crossref 22. Wesselhoeft, C.: Mumps , in Virus and Rickettsial Diseases: Harvard School of Public Health Symposium Volume , Cambridge, Mass., Harvard University Press, 1943, pp. 309-348. 23. Candel, S.: Epididymitis in Mumps, Including Orchitis: Further Clinical Studies and Comments , Ann. Int. Med. 34:20-36, 1951.Crossref 24. Applebaum, I. L.: Serum Amylase in Mumps , Ann. Int. Med. 21:35-43, 1944.Crossref 25. Bennett, I. L., Jr.: The Significance of Fever in Infections , Yale J. Biol. & Med. 26:491-505, 1954. 26. Kinsell, L. W., and Jahn, J. P.: The Use of Corticoids in Association with Antibiotics in the Management of Unusually Severe Infections , Ann. New York Acad. Sc. 61:397-407, 1955. 27. Principles of Internal Medicine , edited by T. R. Harrison, Ed. 2, New York, The Blakiston Company, 1954, pp. 681-682. 28. Jahn, J. P.; Boling. L.; Meagher, T. R.; Peterson, H. H.; Thomas, G.; Fisher, B. M.; Thill, A. E.; Leovy, W. A.; Balch, H. E., and Kinsell, L. W.: The Combination of ACTH-Cortisone-Hydrocortisone with Antibiotics in the Management of Overwhelmingly Severe Infections: Theory and Practice Based on 3 Years' Experience , J. Pediat. 44:640-657, 1954. 29. Solem, J. H.: The Effect of Corticotropin in the Orchitis of Mumps; A Preliminary Report , Acta med. scandinav. 149:341-344, 1954. 30. Bloodworth, A. F., and Cohen, S. L.: Cortisone in Treatment of Acute Pancreatitis Associated with Mumps: Epidemic Parotitis , U. S. Armed Forces M. J. 7:285-287, 1956. 31. Hloucal, L., and Zácek, K.: Über atypische Mumpsmanifestationen, insbesondere die Mumpsmeningoencephalitis , Schweiz. med. Wchnschr. 85:634-637, 1955. 32. Infective Hepatitis Following Mumps, Letters to the Editor , Lancet 1:195, 1947. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Treatment of Mumps Orchitis with Adrenal Hormones: Report of Twenty-Three Cases with a Note on Hepatic Involvement in Mumps

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1957.00260020058010
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Abstract

Abstract Epididymo-orchitis occurs as a complication in the course of mumps in 18% to 43% of postpubertal males.1-4 Not only is gonadal involvement accompanied by severe local pain and systemic discomfort, but testicular atrophy is a sequel in about one-half of the cases, and sterility can result, although this is probably unusual.5,6 Of the various prophylactic measures that have been tried in males with epidemic parotitis, the administration of diethylstilbestrol has given encouraging results,7,8 and early injection of γ-globulin prepared from mumps convalescent serum has resulted in definite reduction in the incidence of orchitis.9 The treatment of established orchitis, however, has remained unsatisfactory. Antibiotics,10-14 pooled plasma,15-17 convalescent serum,18 estrogens,7 and surgical decompression 19-21 have been irregularly effective. At present, the usual regimen consists of analgesic and antipyretic drugs with local application of cold and the use of various suspensory devices. The few available descriptions of the histologie characteristics of mumps orchitis20 References 1. McGuiness, A. C., and Gall, E. A.: Mumps at Army Camps in 1943 , War Med. 5:95-104, 1944. 2. Riley, H. D., Jr.: Complications of Mumps , U. S. Armed Forces M. J. 3:1887-1891, 1952. 3. Greene, J. A., and Heeren, A. H.: Mumps: The Incidence of Palpable Splenic Enlargement and of "Complications," and Their Relation to Salivary Gland Involvement as Evidence that the Disease is a Systemic Infection , J. Lab. & Clin. Med. 23:129-134, 1937. 4. Eagles, A. Y.: Analysis of a 4 Year Epidemic of Mumps , Arch. Int. Med. 80:374-387, 1947. 5. Werner, C. A.: Mumps Orchitis and Testicular Atrophy: II. A Factor in Male Sterility , Ann. Int. Med. 32:1075-1086, 1950. 6. Michelson, L., and Michelson, R. P.: Fertility Studies of the Male in Barren Marriages , J. A. M. A. 134:941-944, 1947. 7. Hoyne, A. L.; Diamond, J. H., and Christian, J. R.: Diethylstilbestrol in Mumps Orchitis: Prophylactic and Therapeutic Use , J. A. M. A. 140:662-665, 1949. 8. Savran, J.: Diethylstilbestrol in the Prevention of Orchitis Following Mumps , Rhode Island M. J. 29:662, 1946. 9. Gellis, S. S.; McGuiness, A. C., and Peters, M.: A Study on the Prevention of Mumps Orchitis by Gamma Globulin , Am. J. M. Sc. 210:661-664, 1945. 10. Sutliff, W. D., and Barnes, Z. B.: Aureomycin, Chloramphenicol, and Oxytetracycline ("Terramycin") in Mumps , A. M. A. Arch. Int. Med. 91:68-77, 1953. 11. Homer, L., and Donovan, W. N.: Aureomycin in Mumps , J. A. M. A. 150:465-467, 1952. 12. Redewill, F. H.: Chloromycetin in the Successful Treatment of Recurring Epididymitis , J. Urol. 62:581-589, 1949. 13. Spinelli, N. P. R.; Cressy, N. L., and Kunkel, P.: Aureomycin in the Treatment of Mumps Orchitis and Encephalitis , Connecticut M. J. 15: 113-116, 1951. 14. Sayer, R. J.; Michel, J. C.; Moll, F. C., and Kirby, W. M. M.: Terramycin: Clinical, Pharmacologic, and Bacteriologic Studies , Am. J. M. Sc. 221:256-263, 1951. 15. Smith, R. S.: Plasma Treatment of Mumps Orchitis , U. S. Nav. M. Bull. 44:159-160, 1945. 16. Huie, R. E., Jr.: Mumps Orchitis Treated with Reactivated Pooled Plasma: Report of 5 Cases , U. S. Nav. M. Bull. 48:897-900, 1948. 17. Rambar, A. C.: Pooled Plasma Treatment of Mumps Orchitis , U. S. Nav. M. Bull. 42:871-873, 1944. 18. Rambar, A. C.: Mumps: Use of Convalescent Serum in the Treatment and Prophylaxis of Orchitis , Am. J. Dis. Child. 71:1-13, 1946. 19. Finn, H. G., and Palmberg, K. J.: Surgical Treatment of Severe Mumps Orchitis , U. S. Nav. M. Bull. 42:1388-1390, 1944. 20. Smith, G. G.: Two Cases of Orchitis Due to Mumps Treated by Operation , Boston M. & S. J. 167:323-325, 1912. 21. Wesselhoeft, C., and Vose, S. N.: Surgical Treatment of Severe Orchitis in Mumps , N. England J. Med. 227:277-280, 1942.Crossref 22. Wesselhoeft, C.: Mumps , in Virus and Rickettsial Diseases: Harvard School of Public Health Symposium Volume , Cambridge, Mass., Harvard University Press, 1943, pp. 309-348. 23. Candel, S.: Epididymitis in Mumps, Including Orchitis: Further Clinical Studies and Comments , Ann. Int. Med. 34:20-36, 1951.Crossref 24. Applebaum, I. L.: Serum Amylase in Mumps , Ann. Int. Med. 21:35-43, 1944.Crossref 25. Bennett, I. L., Jr.: The Significance of Fever in Infections , Yale J. Biol. & Med. 26:491-505, 1954. 26. Kinsell, L. W., and Jahn, J. P.: The Use of Corticoids in Association with Antibiotics in the Management of Unusually Severe Infections , Ann. New York Acad. Sc. 61:397-407, 1955. 27. Principles of Internal Medicine , edited by T. R. Harrison, Ed. 2, New York, The Blakiston Company, 1954, pp. 681-682. 28. Jahn, J. P.; Boling. L.; Meagher, T. R.; Peterson, H. H.; Thomas, G.; Fisher, B. M.; Thill, A. E.; Leovy, W. A.; Balch, H. E., and Kinsell, L. W.: The Combination of ACTH-Cortisone-Hydrocortisone with Antibiotics in the Management of Overwhelmingly Severe Infections: Theory and Practice Based on 3 Years' Experience , J. Pediat. 44:640-657, 1954. 29. Solem, J. H.: The Effect of Corticotropin in the Orchitis of Mumps; A Preliminary Report , Acta med. scandinav. 149:341-344, 1954. 30. Bloodworth, A. F., and Cohen, S. L.: Cortisone in Treatment of Acute Pancreatitis Associated with Mumps: Epidemic Parotitis , U. S. Armed Forces M. J. 7:285-287, 1956. 31. Hloucal, L., and Zácek, K.: Über atypische Mumpsmanifestationen, insbesondere die Mumpsmeningoencephalitis , Schweiz. med. Wchnschr. 85:634-637, 1955. 32. Infective Hepatitis Following Mumps, Letters to the Editor , Lancet 1:195, 1947.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1957

References