Abstract THE TREATMENT of histoplasmosis, particularly of the progressive disseminated type, has been for the most part unsuccessful. In vitro studies by Seabury and Artis 1 revealed that stilbamidine is an effective histoplasmocidal agent, and Snapper has shown that 2-hydroxystilbamidine inhibits the growth of histoplasma capsulatum in vitro in concentrations of 20 to 40 γ per milliliter.2 Because of these findings and inferred benefit from stilbamidine in disseminated cases, we felt that a clinical trial with 2-hydroxystilbamidine was indicated in a case of localized histoplasmosis of the hard palate recently admitted to the Veterans Administration Hospital, Hines, Ill. REPORT OF A CASE A 53-year-old white man, a cattle farmer from Nebraska, first noted a painful area involving the gingiva in the region of his left upper premolar teeth in May, 1953. A small nodule developed in this area, and approximately one month after onset of symptoms it became ulcerated. At References 1. References 9 and 10. 2. Baker, L. A.; Edidin, B. D.; Kushner, D. S., and Snapper, I.: The Results of 2-Hydroxystilbamidine Therapy in Disseminated Coccidioidomycosis, unpublished data. 3. Seabury, J. H., and Artis, D.: In Vitro Susceptibility of Histoplasmosis to Therapeutic Agents , Proc. Soc. Exper. Biol. & Med. 61:15, 1946. 4. Snapper, I.; Schneid, B.; McVay, L., and Lieben, F.: Pharmacology and Therapeutic Value of Diamidine Derivatives, Particularly of 2-Hydroxystilbamidine , Tr. New York Acad. Sc. 14:269, 1952. 5. Christie, A.; Middleton, J. M.; Peterson, J. C., and McVickar, D. L.: Treatment of Disseminated Histoplasmosis with Ethyl Vanillate , Pediatrics 7:7, 1951. 6. Ellis, F. F., Jr.; Scott, J. R., and Miller, J. M.: Treatment of Progressive Disseminated Histoplasmosis with Ethyl Vanillate and Propamidine , Antibiotics & Chemother. 2:347, 1952. 7. Locket, S.; Atkinson, E. A., and Grieve, W. S. M.: Histoplasmosis in Great Britain: Description of a Second Case of Disseminated Histoplasmosis; Treatment by Ethyl Vanillate , Brit. M. J. 2:857, 1953. 8. Parsons, R. J., and Zarafonetis, C.: Histoplasmosis in Man , Arch. Int. Med. 75:1, 1945. 9. Seabury, J. H.: Stilbamidine in the Treatment of Histoplasmosis: Two Case Reports , Ann. Int. Med. 31:520, 1949. 10. Snapper, I.: Influence of 2-Hydroxystilbamidine on the Course of Multiple Myeloma , J. Mt. Sinai Hosp. 15:156, 1948. 11. Snapper, I., and McVay, L. V., Jr.: The Treatment of North America Blastomycosis with 2-Hydroxystilbamidine , Am. J. Med. 15:603, 1953. 12. Sutliff, W. D.; Kyle, J. W., and Hobson, J. L.: North American Blastomycosis: Clinical Forms of the Disease and Treatment with Stilbamidine and 2-Hydroxystilbamidine , Ann. Int. Med. 41:89, 1954.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Jan 1, 1955