Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

TREATMENT OF LOCALIZED HISTOPLASMOSIS WITH 2-HYDROXYSTILBAMIDINE

TREATMENT OF LOCALIZED HISTOPLASMOSIS WITH 2-HYDROXYSTILBAMIDINE Abstract THE TREATMENT of histoplasmosis, particularly of the progressive disseminated type, has been for the most part unsuccessful. In vitro studies by Seabury and Artis 1 revealed that stilbamidine is an effective histoplasmocidal agent, and Snapper has shown that 2-hydroxystilbamidine inhibits the growth of histoplasma capsulatum in vitro in concentrations of 20 to 40 γ per milliliter.2 Because of these findings and inferred benefit from stilbamidine in disseminated cases, we felt that a clinical trial with 2-hydroxystilbamidine was indicated in a case of localized histoplasmosis of the hard palate recently admitted to the Veterans Administration Hospital, Hines, Ill. REPORT OF A CASE A 53-year-old white man, a cattle farmer from Nebraska, first noted a painful area involving the gingiva in the region of his left upper premolar teeth in May, 1953. A small nodule developed in this area, and approximately one month after onset of symptoms it became ulcerated. At References 1. References 9 and 10. 2. Baker, L. A.; Edidin, B. D.; Kushner, D. S., and Snapper, I.: The Results of 2-Hydroxystilbamidine Therapy in Disseminated Coccidioidomycosis, unpublished data. 3. Seabury, J. H., and Artis, D.: In Vitro Susceptibility of Histoplasmosis to Therapeutic Agents , Proc. Soc. Exper. Biol. & Med. 61:15, 1946. 4. Snapper, I.; Schneid, B.; McVay, L., and Lieben, F.: Pharmacology and Therapeutic Value of Diamidine Derivatives, Particularly of 2-Hydroxystilbamidine , Tr. New York Acad. Sc. 14:269, 1952. 5. Christie, A.; Middleton, J. M.; Peterson, J. C., and McVickar, D. L.: Treatment of Disseminated Histoplasmosis with Ethyl Vanillate , Pediatrics 7:7, 1951. 6. Ellis, F. F., Jr.; Scott, J. R., and Miller, J. M.: Treatment of Progressive Disseminated Histoplasmosis with Ethyl Vanillate and Propamidine , Antibiotics & Chemother. 2:347, 1952. 7. Locket, S.; Atkinson, E. A., and Grieve, W. S. M.: Histoplasmosis in Great Britain: Description of a Second Case of Disseminated Histoplasmosis; Treatment by Ethyl Vanillate , Brit. M. J. 2:857, 1953. 8. Parsons, R. J., and Zarafonetis, C.: Histoplasmosis in Man , Arch. Int. Med. 75:1, 1945. 9. Seabury, J. H.: Stilbamidine in the Treatment of Histoplasmosis: Two Case Reports , Ann. Int. Med. 31:520, 1949. 10. Snapper, I.: Influence of 2-Hydroxystilbamidine on the Course of Multiple Myeloma , J. Mt. Sinai Hosp. 15:156, 1948. 11. Snapper, I., and McVay, L. V., Jr.: The Treatment of North America Blastomycosis with 2-Hydroxystilbamidine , Am. J. Med. 15:603, 1953. 12. Sutliff, W. D.; Kyle, J. W., and Hobson, J. L.: North American Blastomycosis: Clinical Forms of the Disease and Treatment with Stilbamidine and 2-Hydroxystilbamidine , Ann. Int. Med. 41:89, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

TREATMENT OF LOCALIZED HISTOPLASMOSIS WITH 2-HYDROXYSTILBAMIDINE

Loading next page...
 
/lp/american-medical-association/treatment-of-localized-histoplasmosis-with-2-hydroxystilbamidine-KpzAqB000X
Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1955.00250070053006
Publisher site
See Article on Publisher Site

Abstract

Abstract THE TREATMENT of histoplasmosis, particularly of the progressive disseminated type, has been for the most part unsuccessful. In vitro studies by Seabury and Artis 1 revealed that stilbamidine is an effective histoplasmocidal agent, and Snapper has shown that 2-hydroxystilbamidine inhibits the growth of histoplasma capsulatum in vitro in concentrations of 20 to 40 γ per milliliter.2 Because of these findings and inferred benefit from stilbamidine in disseminated cases, we felt that a clinical trial with 2-hydroxystilbamidine was indicated in a case of localized histoplasmosis of the hard palate recently admitted to the Veterans Administration Hospital, Hines, Ill. REPORT OF A CASE A 53-year-old white man, a cattle farmer from Nebraska, first noted a painful area involving the gingiva in the region of his left upper premolar teeth in May, 1953. A small nodule developed in this area, and approximately one month after onset of symptoms it became ulcerated. At References 1. References 9 and 10. 2. Baker, L. A.; Edidin, B. D.; Kushner, D. S., and Snapper, I.: The Results of 2-Hydroxystilbamidine Therapy in Disseminated Coccidioidomycosis, unpublished data. 3. Seabury, J. H., and Artis, D.: In Vitro Susceptibility of Histoplasmosis to Therapeutic Agents , Proc. Soc. Exper. Biol. & Med. 61:15, 1946. 4. Snapper, I.; Schneid, B.; McVay, L., and Lieben, F.: Pharmacology and Therapeutic Value of Diamidine Derivatives, Particularly of 2-Hydroxystilbamidine , Tr. New York Acad. Sc. 14:269, 1952. 5. Christie, A.; Middleton, J. M.; Peterson, J. C., and McVickar, D. L.: Treatment of Disseminated Histoplasmosis with Ethyl Vanillate , Pediatrics 7:7, 1951. 6. Ellis, F. F., Jr.; Scott, J. R., and Miller, J. M.: Treatment of Progressive Disseminated Histoplasmosis with Ethyl Vanillate and Propamidine , Antibiotics & Chemother. 2:347, 1952. 7. Locket, S.; Atkinson, E. A., and Grieve, W. S. M.: Histoplasmosis in Great Britain: Description of a Second Case of Disseminated Histoplasmosis; Treatment by Ethyl Vanillate , Brit. M. J. 2:857, 1953. 8. Parsons, R. J., and Zarafonetis, C.: Histoplasmosis in Man , Arch. Int. Med. 75:1, 1945. 9. Seabury, J. H.: Stilbamidine in the Treatment of Histoplasmosis: Two Case Reports , Ann. Int. Med. 31:520, 1949. 10. Snapper, I.: Influence of 2-Hydroxystilbamidine on the Course of Multiple Myeloma , J. Mt. Sinai Hosp. 15:156, 1948. 11. Snapper, I., and McVay, L. V., Jr.: The Treatment of North America Blastomycosis with 2-Hydroxystilbamidine , Am. J. Med. 15:603, 1953. 12. Sutliff, W. D.; Kyle, J. W., and Hobson, J. L.: North American Blastomycosis: Clinical Forms of the Disease and Treatment with Stilbamidine and 2-Hydroxystilbamidine , Ann. Int. Med. 41:89, 1954.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1955

References