Abstract My colleagues and I recently described the successful treatment of keratoacanthoma (KA) with intralesional1,2 and topical 20% fluorouracil cream.3 The latter preparation is commercially unavailable and cumbersome to prepare. Therefore, we evaluated the use of topical 5% fluorouracil cream for the treatment of KA, and our results are described herein. Patients and Methods Patient data are shown in the Table. Rapidly growing lesions of 4 to 16 mm developed during periods of three to six weeks in 13 patients who ranged in age from 58 to 86 years. One patient had three such lesions when he was examined. All patients met the criteria for the clinical diagnosis of KA, namely, (1) rapid growth of the lesion for two to six weeks, (2) morphologic characteristics of a dome-shaped, smooth, skin-colored or erythematous nodule with a central keratin-filled crater, and (3) subsequent prompt response to topical fluorouracil therapy with at References 1. Odom RB, Goette DK: Treatment of keratoacanthomas with intralesional fluorouracil . Arch Dermatol 1978;114:1779-1783.Crossref 2. Goette DK, Odom RB: Successful treatment of keratoacanthoma with intralesional fluorouracil . J Am Acad Dermatol 1980;2:212-216.Crossref 3. Goette DK, Odom RB, Arrot J, et al: Treatment of keratoacanthomas with topical fluorouracil . Arch Dermatol 1982; 118:309-311.Crossref 4. Ebner H: Treatment of skin epitheliomas with 5-fluorouracil ointment: Influence of therapeutic design on recurrence of lesions . Dermatologica 1970;140( (suppl 1) ):42-46.Crossref 5. Midana A, Leigheb G: 5-Fluorouracil ointment in the treatment of benign and malignant skin lesions . Dermatologica 1970;140( (suppl 1) ):75-81.Crossref 6. Llombart Bosch M, Espinosa Cabanero JA: Preliminary experience with 5-fluorouracil ointment in the treatment of neoplasias and precancerous lesions of the skin . Dermatologica 1970;140( (suppl 1) ):82-89.Crossref 7. Banazzi M: Clinical and structural evaluation of the treatment of some hyperplastic and enoplastic skin diseases with 5-fluorouracil ointment . Dermatologica 1970;140( (suppl 1) ):90-96.Crossref 8. Woodridge WE, Frerichs JB: Multiple adenoid squamous cell carcinomas . Arch Dermatol 1971;104:202-206.Crossref 9. Williams AL: Topical 5FU: A new approach to skin cancer . Ann Surg 1971;173:864-871.Crossref 10. Grupper C: Treatment of keratoacanthomas by local applications of 5-fluorouracil ointment . Dermatologica 1970;140( (suppl 1) ):127-132.Crossref 11. Ebner H, Mischer P: Lokalbehandlung des Keratoacanthoms mit 5-Fluorouracil . Hautarzt 1975;26:585-588.
Archives of Dermatology – American Medical Association
Published: Nov 1, 1983