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Treatment of Keloids with Topical Injections of Hydrocortisone Acetate

Treatment of Keloids with Topical Injections of Hydrocortisone Acetate Abstract Fresh keloids consist of dense bundles of collagenous fibrils and an ample mucinous ground substance with a high content of mucopolysaccharides. Mast cells and fibroblasts are present in large numbers. Keloids of longer standing are less cellular, with fibril bundles predominating, whereas the ground substance is less ample. Since cortisone and hydrocortisone are known to influence the chemistry and morphology of connective tissue cells and to inhibit their production of intercellular substance,1 it is reasonable to expect that keloids would be susceptible to treatment with adrenocortical steroids. In patients with Cushing's syndrome wounds and scars are apt to become distended. This is also observed in patients on systemic treatment with corticotropin (ACTH) and cortisone. In such patients softening of keloids has been noted as well.* This effect is, however, too slight and undependable to acquire any therapeutic importance. A more marked effect must be expected References 1. References 2, 5, and 6. 2. Hydrocortisat Leo, supplied through the courtesy of Leo Pharmaceutical Products, Copenhagen. 3. Asboe-Hansen, G.: Hormonal Effects on Connective Tissues , in Connective Tissues, Transactions of the Fifth Conference, New York, Josiah Macy, Jr., Foundation, 1954 . 4. Behrman, H. T., and Goodman, J. J.: Skin Complications of Cortisone and ACTH Therapy , J. A. M. A. 144:218, 1950.Crossref 5. Conway, H., and Stark, R. B.: Corticotropin (ACTH) in Treatment of Keloids , A. M. A. Arch. Surg. 64:47, 1952.Crossref 6. Degos, R.; Vial-Weissenbach, V., and Grupper, C.: Traitement de chéloïdes par injections locales d'hydrocortisone, in transactions of Société Française de Dermatologie et de Syphiligraphie , Presse méd. 61:1157, 1953. 7. De Kleine, E. H.: Observations on the Effect of Cortisone on Wound Healing and Scar Formation , Plast. & Reconstruct. Surg. 9:473, 1952. 8. Ronchese, F., and Kern, A. B.: ACTH and Cortisone in the Treatment of Keloids , New England J. Med. 250:238, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Treatment of Keloids with Topical Injections of Hydrocortisone Acetate

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550020062009
Publisher site
See Article on Publisher Site

Abstract

Abstract Fresh keloids consist of dense bundles of collagenous fibrils and an ample mucinous ground substance with a high content of mucopolysaccharides. Mast cells and fibroblasts are present in large numbers. Keloids of longer standing are less cellular, with fibril bundles predominating, whereas the ground substance is less ample. Since cortisone and hydrocortisone are known to influence the chemistry and morphology of connective tissue cells and to inhibit their production of intercellular substance,1 it is reasonable to expect that keloids would be susceptible to treatment with adrenocortical steroids. In patients with Cushing's syndrome wounds and scars are apt to become distended. This is also observed in patients on systemic treatment with corticotropin (ACTH) and cortisone. In such patients softening of keloids has been noted as well.* This effect is, however, too slight and undependable to acquire any therapeutic importance. A more marked effect must be expected References 1. References 2, 5, and 6. 2. Hydrocortisat Leo, supplied through the courtesy of Leo Pharmaceutical Products, Copenhagen. 3. Asboe-Hansen, G.: Hormonal Effects on Connective Tissues , in Connective Tissues, Transactions of the Fifth Conference, New York, Josiah Macy, Jr., Foundation, 1954 . 4. Behrman, H. T., and Goodman, J. J.: Skin Complications of Cortisone and ACTH Therapy , J. A. M. A. 144:218, 1950.Crossref 5. Conway, H., and Stark, R. B.: Corticotropin (ACTH) in Treatment of Keloids , A. M. A. Arch. Surg. 64:47, 1952.Crossref 6. Degos, R.; Vial-Weissenbach, V., and Grupper, C.: Traitement de chéloïdes par injections locales d'hydrocortisone, in transactions of Société Française de Dermatologie et de Syphiligraphie , Presse méd. 61:1157, 1953. 7. De Kleine, E. H.: Observations on the Effect of Cortisone on Wound Healing and Scar Formation , Plast. & Reconstruct. Surg. 9:473, 1952. 8. Ronchese, F., and Kern, A. B.: ACTH and Cortisone in the Treatment of Keloids , New England J. Med. 250:238, 1954.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1956

References