Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Ronchese (1954)
ACTH and Cortisone in the Treatment of KeloidsNew England J. Med., 250
H. T. Behrman (1950)
Skin Complications of Cortisone and ACTH TherapyJ. A. M. A., 144
R. Degos , V. Vial-Weissenbach (1953)
Traitement de chéloïdes par injections locales d'hydrocortisone, in transactions of Société Française de Dermatologie et de SyphiligraphiePresse méd., 61
H. Conway (1952)
Corticotropin (ACTH) in Treatment of KeloidsA. M. A. Arch. Surg., 64
G. Asboe-Hansen
Fifth Conference, New York, Josiah Macy, Jr., Foundation, 1954
E. H. De Kleine (1952)
Observations on the Effect of Cortisone on Wound Healing and Scar FormationPlast. & Reconstruct. Surg., 9
Abstract Fresh keloids consist of dense bundles of collagenous fibrils and an ample mucinous ground substance with a high content of mucopolysaccharides. Mast cells and fibroblasts are present in large numbers. Keloids of longer standing are less cellular, with fibril bundles predominating, whereas the ground substance is less ample. Since cortisone and hydrocortisone are known to influence the chemistry and morphology of connective tissue cells and to inhibit their production of intercellular substance,1 it is reasonable to expect that keloids would be susceptible to treatment with adrenocortical steroids. In patients with Cushing's syndrome wounds and scars are apt to become distended. This is also observed in patients on systemic treatment with corticotropin (ACTH) and cortisone. In such patients softening of keloids has been noted as well.* This effect is, however, too slight and undependable to acquire any therapeutic importance. A more marked effect must be expected References 1. References 2, 5, and 6. 2. Hydrocortisat Leo, supplied through the courtesy of Leo Pharmaceutical Products, Copenhagen. 3. Asboe-Hansen, G.: Hormonal Effects on Connective Tissues , in Connective Tissues, Transactions of the Fifth Conference, New York, Josiah Macy, Jr., Foundation, 1954 . 4. Behrman, H. T., and Goodman, J. J.: Skin Complications of Cortisone and ACTH Therapy , J. A. M. A. 144:218, 1950.Crossref 5. Conway, H., and Stark, R. B.: Corticotropin (ACTH) in Treatment of Keloids , A. M. A. Arch. Surg. 64:47, 1952.Crossref 6. Degos, R.; Vial-Weissenbach, V., and Grupper, C.: Traitement de chéloïdes par injections locales d'hydrocortisone, in transactions of Société Française de Dermatologie et de Syphiligraphie , Presse méd. 61:1157, 1953. 7. De Kleine, E. H.: Observations on the Effect of Cortisone on Wound Healing and Scar Formation , Plast. & Reconstruct. Surg. 9:473, 1952. 8. Ronchese, F., and Kern, A. B.: ACTH and Cortisone in the Treatment of Keloids , New England J. Med. 250:238, 1954.
A.M.A. Archives of Dermatology – American Medical Association
Published: Feb 1, 1956
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.