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TREATMENT OF HYPERTHYROIDISM WITH 1-METHYL-2-MERCAPTOIMIDAZOLE

TREATMENT OF HYPERTHYROIDISM WITH 1-METHYL-2-MERCAPTOIMIDAZOLE We have used a new antithyroid drug, 1-methyl-2-mercaptoimidazole (tapazol), in the treatment of 18 patients with hyperthyroidism during a six month period and have found it fully as efficient as thiouracil and propylthiouracil in this condition. Toxic reactions were not observed. The new compound is one of the imidazoles and differs from the well known antithyroid drugs in that it has a five-membered rather than a six-membered ring. (See the accompanying structural formulas.) Its powerful antithyroid activity was noted by Stanley and Astwood1 when they were testing a number of similar compounds by the radioactive iodine technic.2 A pronounced effect on iodine accumulation in the thyroid was noted with as little as 0.5 mg. of the compound, and 5.0 mg. completely inhibited the uptake of iodine for nearly twenty-four hours. Comparative studies place the action of the drug above that of thiouracil, methylthiouracil, propylthiouracil and 2-mercaptoimidazole and rate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

TREATMENT OF HYPERTHYROIDISM WITH 1-METHYL-2-MERCAPTOIMIDAZOLE

REVENO, WILLIAM S.; ROSENBAUM, HERBERT
JAMA , Volume 143 (16) – Aug 19, 1950
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1950.02910510025006
Publisher site
See Article on Publisher Site

Abstract

We have used a new antithyroid drug, 1-methyl-2-mercaptoimidazole (tapazol), in the treatment of 18 patients with hyperthyroidism during a six month period and have found it fully as efficient as thiouracil and propylthiouracil in this condition. Toxic reactions were not observed. The new compound is one of the imidazoles and differs from the well known antithyroid drugs in that it has a five-membered rather than a six-membered ring. (See the accompanying structural formulas.) Its powerful antithyroid activity was noted by Stanley and Astwood1 when they were testing a number of similar compounds by the radioactive iodine technic.2 A pronounced effect on iodine accumulation in the thyroid was noted with as little as 0.5 mg. of the compound, and 5.0 mg. completely inhibited the uptake of iodine for nearly twenty-four hours. Comparative studies place the action of the drug above that of thiouracil, methylthiouracil, propylthiouracil and 2-mercaptoimidazole and rate

Journal

JAMA – American Medical Association

Published: Aug 19, 1950

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