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Treatment of Group A Streptococcal Pharyngitis in Children: Comparison of Lincomycin and Penicillin G Given Orally and Benzathine Penicillin G Given Intramuscularly

Treatment of Group A Streptococcal Pharyngitis in Children: Comparison of Lincomycin and... Abstract Two hundred twenty-eight children with group A β-streptococcal pharyngitis, or carrier state, were treated with one of three treatment regimes from September 1969 to March 1970 and followed-up with throat cultures at 5, 14, 31, and 60 days. Treatment groups were benzathine penicillin G given intramuscularly, and penicillin G potassium and lincomycin hydrochloride monohydrate, administered orally. Lincomycin hydrochloride monohydrate given orally in recommended dosages for ten days was found to be as effective as benzathine penicillin G given intramuscularly (cure rates at 31 days, 86.8% and 88.9%, respectively). Both drugs were more effective than penicillin G given orally for ten days (31-day cure rate, 70%). The 60-day cure rates were 84% for lincomycin given orally, 72% for benzathine penicillin G given intramuscularly, and 60% for penicillin G given orally. References 1. Breese BB: Treatment of β-hemolytic streptococcic infections in the home: Relative value of available methods . JAMA 152:10-14, 1953.Crossref 2. Haight TH: Erythromycin therapy of respiratory infections: Controlled studies on the comparative efficacy of erythromycin and penicillin in scarlet fever . J Lab Clin Med 43:15-30, 1954. 3. Brink WR, Rammelkamp CH Jr, Denny FW, et al: Effect of penicillin and aureomycin on the natural course of streptococcal tonsillitis and pharyngitis . Amer J Med 10:300-308, 1951.Crossref 4. Breese BB, Disney FA: Penicillin in the treatment of streptococcal infections: A comparison of effectiveness of five different oral and one parenteral form . New Eng J Med 259:57-62, 1958.Crossref 5. Breese BB, Disney FA: A comparison of intramuscular and oral benzathine penicillin G in the treatment of streptococcal infections in children . J Pediat 51:157-163, 1957.Crossref 6. Edmond EW, Cramblett HG, Siewers CMF, et al: Pediatric pharmacology and therapeutics: Comparison of efficacy of phenoxymethyl penicillin and buffered penicillin G in treatment of streptococcal pharyngitis . J Pediat 68:442-447, 1966.Crossref 7. Mohler DN, Wallin DG, Dreyfus EG, et al: Studies in the home treatment of steptococcal disease: II. A comparison of the efficacy of oral administration of penicillin and intramuscular injection of benzathine penicillin in the treatment of streptococcal pharyngitis . New Eng J Med 254:45-50, 1956.Crossref 8. Mortimer EA Jr, Boxerbaum B: Diagnosis and treatment: Group A streptococcal infections . Pediatrics 36:930-932, 1965. 9. Bergman AB, Werner RJ: Failure of children to receive penicillin by mouth . New Eng J Med 268:1334-1338, 1963.Crossref 10. Charney E, Bynum R, Eldredge D, et al: How well do patients take oral penicillin? A collaborative study in private practice . Pediatrics 40:188-195, 1967. 11. Green JL, Ray SP, Charney E: Recurrence rate of streptococcal pharyngitis related to oral penicillin . J Pediat 75:292-294, 1969.Crossref 12. Breese BB, Disney FA, Talpey WB, et al: β-Hemolytic streptococcal infection: Comparison of penicillin and lincomycin in the treatment of recurrent infections or the carrier state . Amer J Dis Child 117:147-152, 1969.Crossref 13. Randolph MF, DeHaan RM: A comparison of lincomycin and penicillin in the treatment of group A streptococcal infections: Speculation on the 'L' form as a mechanism of recurrence . Delaware Med J 41:51-62, 1969. 14. Breese BB, Disney FA, Talpey WB: β-Hemolytic streptococcal illness: Comparison of lincomycin, ampicillin, and potassium penicillin G in treatment . Amer J Dis Child 112:21-27, 1966.Crossref 15. Randolph MF, Redys JJ, Hibbard E: Streptococcal pharyngitis: Part 3. Streptococcal recurrence rate following therapy with penicillin or with clindamycin (7-chlorolincomycin) . Delaware Med J 42:87-92, 1970. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Treatment of Group A Streptococcal Pharyngitis in Children: Comparison of Lincomycin and Penicillin G Given Orally and Benzathine Penicillin G Given Intramuscularly

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1971 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1971.02100170059005
Publisher site
See Article on Publisher Site

Abstract

Abstract Two hundred twenty-eight children with group A β-streptococcal pharyngitis, or carrier state, were treated with one of three treatment regimes from September 1969 to March 1970 and followed-up with throat cultures at 5, 14, 31, and 60 days. Treatment groups were benzathine penicillin G given intramuscularly, and penicillin G potassium and lincomycin hydrochloride monohydrate, administered orally. Lincomycin hydrochloride monohydrate given orally in recommended dosages for ten days was found to be as effective as benzathine penicillin G given intramuscularly (cure rates at 31 days, 86.8% and 88.9%, respectively). Both drugs were more effective than penicillin G given orally for ten days (31-day cure rate, 70%). The 60-day cure rates were 84% for lincomycin given orally, 72% for benzathine penicillin G given intramuscularly, and 60% for penicillin G given orally. References 1. Breese BB: Treatment of β-hemolytic streptococcic infections in the home: Relative value of available methods . JAMA 152:10-14, 1953.Crossref 2. Haight TH: Erythromycin therapy of respiratory infections: Controlled studies on the comparative efficacy of erythromycin and penicillin in scarlet fever . J Lab Clin Med 43:15-30, 1954. 3. Brink WR, Rammelkamp CH Jr, Denny FW, et al: Effect of penicillin and aureomycin on the natural course of streptococcal tonsillitis and pharyngitis . Amer J Med 10:300-308, 1951.Crossref 4. Breese BB, Disney FA: Penicillin in the treatment of streptococcal infections: A comparison of effectiveness of five different oral and one parenteral form . New Eng J Med 259:57-62, 1958.Crossref 5. Breese BB, Disney FA: A comparison of intramuscular and oral benzathine penicillin G in the treatment of streptococcal infections in children . J Pediat 51:157-163, 1957.Crossref 6. Edmond EW, Cramblett HG, Siewers CMF, et al: Pediatric pharmacology and therapeutics: Comparison of efficacy of phenoxymethyl penicillin and buffered penicillin G in treatment of streptococcal pharyngitis . J Pediat 68:442-447, 1966.Crossref 7. Mohler DN, Wallin DG, Dreyfus EG, et al: Studies in the home treatment of steptococcal disease: II. A comparison of the efficacy of oral administration of penicillin and intramuscular injection of benzathine penicillin in the treatment of streptococcal pharyngitis . New Eng J Med 254:45-50, 1956.Crossref 8. Mortimer EA Jr, Boxerbaum B: Diagnosis and treatment: Group A streptococcal infections . Pediatrics 36:930-932, 1965. 9. Bergman AB, Werner RJ: Failure of children to receive penicillin by mouth . New Eng J Med 268:1334-1338, 1963.Crossref 10. Charney E, Bynum R, Eldredge D, et al: How well do patients take oral penicillin? A collaborative study in private practice . Pediatrics 40:188-195, 1967. 11. Green JL, Ray SP, Charney E: Recurrence rate of streptococcal pharyngitis related to oral penicillin . J Pediat 75:292-294, 1969.Crossref 12. Breese BB, Disney FA, Talpey WB, et al: β-Hemolytic streptococcal infection: Comparison of penicillin and lincomycin in the treatment of recurrent infections or the carrier state . Amer J Dis Child 117:147-152, 1969.Crossref 13. Randolph MF, DeHaan RM: A comparison of lincomycin and penicillin in the treatment of group A streptococcal infections: Speculation on the 'L' form as a mechanism of recurrence . Delaware Med J 41:51-62, 1969. 14. Breese BB, Disney FA, Talpey WB: β-Hemolytic streptococcal illness: Comparison of lincomycin, ampicillin, and potassium penicillin G in treatment . Amer J Dis Child 112:21-27, 1966.Crossref 15. Randolph MF, Redys JJ, Hibbard E: Streptococcal pharyngitis: Part 3. Streptococcal recurrence rate following therapy with penicillin or with clindamycin (7-chlorolincomycin) . Delaware Med J 42:87-92, 1970.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1971

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