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Treatment of Group A Streptococcal Infections: Comparison of Sulfamethoxazole and Buffered Penicillin G

Treatment of Group A Streptococcal Infections: Comparison of Sulfamethoxazole and Buffered... Abstract DEMONSTRATION of the unique role of group A streptococcal respiratory infection in the precipitation of rheumatic fever led to the development of methods of preventing rheumatic fever by penicillin treatment of streptococcal infection. Instances in which penicillin treatment fails to prevent subsequent rheumatic fever usually can be related to the reappearance of the infecting strain in the throat or nose.1-3 Therefore, if any method of therapy of streptococcal infection is to be effective in the prevention of rheumatic fever, it should eradicate the group A Streptococcus from the tissues. Early studies with sulfonamides indicated that treatment of group A streptococcal infections with these drugs did not prevent rheumatic fever.4,5 Subsequently, these results seemed to be explained by the fact that sulfanilamide, sulfadiazine, and other sulfonamides, in contrast to penicillin, are bacteriostatic rather than bactericidal for group A streptococci. Thus, although streptococci in tissues of the upper respiratory tract References 1. Massell, B.F., et al: Prevention of Rheumatic Fever by Prompt Penicillin Therapy of Hemolytic Streptococcic Respiratory Infections , JAMA 146: 1469-1474 ( (Aug 18) ) 1951.Crossref 2. Houser, H.B., and Eckhardt, G.C.: Recent Developments in the Prevention of Rheumatic Fever , Ann Intern Med 37:1035-1043 ( (Nov) ) 1952.Crossref 3. Catanzaro, F.J.; Rammelkamp, C.H., Jr.; and Chamovitz, R.: Prevention of Rheumatic Fever by Treatment of Streptococcal Infections: II. Factors Responsible for Failures , New Eng J Med 259:51-57 ( (July 10) ) 1958.Crossref 4. Massell, B.F., and Jones, T.D.: The Effect of Sulfanilamide on Rheumatic Fever and Chorea , New Eng J Med 218:876-878 ( (May 26) ) 1938.Crossref 5. Coburn, A.F., and Moore, L.V.: The Propylactic Use of Sulfanilamide in Streptococcal Respiratory Infections, With Especial Reference to Rheumatic Fever , J Clin Invest 18:147-155 ( (Jan) ) 1939.Crossref 6. Plummer, N., et al: Penicillin Therapy in Hemolytic Streptococcic Pharyngitis and Tonsillitis , JAMA 127:369-374 ( (Feb 17) ) 1945.Crossref 7. Commission on Acute Respiratory Diseases: A Study of a Food-borne Epidemic of Tonsillitis and Pharyngitis Due to Beta Hemolytic Streptococcus, Type 5 , Bull Hopkins Hosp 77:143-210, 1945. 8. Meads, M., et al: Penicillin Treatment of Scarlet Fever: Bacteriologic Study of the Nose and Throat of Patients Treated Intramuscularly or by Spray With Penicillin and a Comparison With Sulfadiazine , JAMA 129:785-789 ( (Nov 17) ) 1945.Crossref 9. Hamburger, M., Jr., and Lemon, H.M.: The Problem of the Dangerous Carrier of Hemolytic Streptococci: III. The Chemotherapeutic Control of Nasal Carriers , JAMA 130:836-841 ( (March 30) ) 1946.Crossref 10. Morris, A.J., et al: Prevention of Rheumatic Fever by Treatment of Previous Streptococcic Infections: Effect of Sulfadiazine , JAMA 160:114-116 ( (Jan 14) ) 1956.Crossref 11. Breese, B.B.: Treatment of Beta Hemolytic Streptococcic Infections in the Home: Relative Value of Available Methods , JAMA 152:10-14 ( (May 2) ) 1953.Crossref 12. LaBocetta, A.C., et al: Scarlet Fever: Results of a Controlled Study of 609 Patients Treated With Penicillin and Sulfisoxazole , Amer J Med 22:458-468 ( (March) ) 1957.Crossref 13. Braden, B., and Colmore, J.P.: Comparison of a New Sulfonamide and Penicillin in the Treatment of Acute Streptococcal Pharyngitis , J Okla Med Assoc 57:7-10 ( (Jan) ) 1964. 14. Peters, J.H.: Treatment of Streptococcus Pyogenes Infections With a New Sulfonamide, 5-methyl-3-sulfanilamido-isoxazole , Antimicrob Agents Chemother ( (1961) ), pp 406-413, 1962. 15. Reichelderfer, T.E.: Clinical Studies and Therapeutic Use of Sulfamethoxazole in a Pediatric Out-Patient Clinic , Clin Med 71:1045-1055 ( (June) ) 1964. 16. Alban, J.: Treatment of β-Hemolytic Streptococcal Infection: A Study of the Pediatric Use of Sulfamethoxazole , Amer J Dis Child 109:304-307 ( (April) ) 1965.Crossref 17. Miller, J.M.; Stancer, S.L.; and Massell, B.F.: A Controlled Study of Beta Hemolytic Streptococcal Infection in Rheumatic Families: I. Streptococcal Disease Among Healthy Siblings , Amer J Med 25:825-844 ( (Dec) ) 1958.Crossref 18. Swift, H.F.; Wilson, A.T.; and Lancefield, R.C.: Typing Group A Hemolytic Streptococci by M Precipitin Reactions in Capillary Pipettes , J Exp Med 78:127-133 ( (Aug 1) ) 1943.Crossref 19. Massell, B.F.; Amezcua, J.; and Michael, J.G.: Home Cultures as an Aid in the Diagnosis of Streptococcal Respiratory Infection: Evaluation of the Filter-Paper Strip as a Transport Medium , New Eng J Med 271:581-585 ( (Sept 17) ) 1964.Crossref 20. Hill, A.B.: Principles of Medical Statistics , ed 5, London: The Lancet Ltd., 1950, p 139. 21. Fisher, R.A.: Statistical Methods for Research Workers , ed 10, Edinburgh: Oliver & Boyd Ltd., 1946, p 96. 22. Committee Report, American Heart Association, Prevention of Rheumatic Fever and Bacterial Endocarditis Through Control of Streptococcal Infections , Circulation 21:151-155 ( (Jan) ) 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Treatment of Group A Streptococcal Infections: Comparison of Sulfamethoxazole and Buffered Penicillin G

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100030453012
Publisher site
See Article on Publisher Site

Abstract

Abstract DEMONSTRATION of the unique role of group A streptococcal respiratory infection in the precipitation of rheumatic fever led to the development of methods of preventing rheumatic fever by penicillin treatment of streptococcal infection. Instances in which penicillin treatment fails to prevent subsequent rheumatic fever usually can be related to the reappearance of the infecting strain in the throat or nose.1-3 Therefore, if any method of therapy of streptococcal infection is to be effective in the prevention of rheumatic fever, it should eradicate the group A Streptococcus from the tissues. Early studies with sulfonamides indicated that treatment of group A streptococcal infections with these drugs did not prevent rheumatic fever.4,5 Subsequently, these results seemed to be explained by the fact that sulfanilamide, sulfadiazine, and other sulfonamides, in contrast to penicillin, are bacteriostatic rather than bactericidal for group A streptococci. Thus, although streptococci in tissues of the upper respiratory tract References 1. Massell, B.F., et al: Prevention of Rheumatic Fever by Prompt Penicillin Therapy of Hemolytic Streptococcic Respiratory Infections , JAMA 146: 1469-1474 ( (Aug 18) ) 1951.Crossref 2. Houser, H.B., and Eckhardt, G.C.: Recent Developments in the Prevention of Rheumatic Fever , Ann Intern Med 37:1035-1043 ( (Nov) ) 1952.Crossref 3. Catanzaro, F.J.; Rammelkamp, C.H., Jr.; and Chamovitz, R.: Prevention of Rheumatic Fever by Treatment of Streptococcal Infections: II. Factors Responsible for Failures , New Eng J Med 259:51-57 ( (July 10) ) 1958.Crossref 4. Massell, B.F., and Jones, T.D.: The Effect of Sulfanilamide on Rheumatic Fever and Chorea , New Eng J Med 218:876-878 ( (May 26) ) 1938.Crossref 5. Coburn, A.F., and Moore, L.V.: The Propylactic Use of Sulfanilamide in Streptococcal Respiratory Infections, With Especial Reference to Rheumatic Fever , J Clin Invest 18:147-155 ( (Jan) ) 1939.Crossref 6. Plummer, N., et al: Penicillin Therapy in Hemolytic Streptococcic Pharyngitis and Tonsillitis , JAMA 127:369-374 ( (Feb 17) ) 1945.Crossref 7. Commission on Acute Respiratory Diseases: A Study of a Food-borne Epidemic of Tonsillitis and Pharyngitis Due to Beta Hemolytic Streptococcus, Type 5 , Bull Hopkins Hosp 77:143-210, 1945. 8. Meads, M., et al: Penicillin Treatment of Scarlet Fever: Bacteriologic Study of the Nose and Throat of Patients Treated Intramuscularly or by Spray With Penicillin and a Comparison With Sulfadiazine , JAMA 129:785-789 ( (Nov 17) ) 1945.Crossref 9. Hamburger, M., Jr., and Lemon, H.M.: The Problem of the Dangerous Carrier of Hemolytic Streptococci: III. The Chemotherapeutic Control of Nasal Carriers , JAMA 130:836-841 ( (March 30) ) 1946.Crossref 10. Morris, A.J., et al: Prevention of Rheumatic Fever by Treatment of Previous Streptococcic Infections: Effect of Sulfadiazine , JAMA 160:114-116 ( (Jan 14) ) 1956.Crossref 11. Breese, B.B.: Treatment of Beta Hemolytic Streptococcic Infections in the Home: Relative Value of Available Methods , JAMA 152:10-14 ( (May 2) ) 1953.Crossref 12. LaBocetta, A.C., et al: Scarlet Fever: Results of a Controlled Study of 609 Patients Treated With Penicillin and Sulfisoxazole , Amer J Med 22:458-468 ( (March) ) 1957.Crossref 13. Braden, B., and Colmore, J.P.: Comparison of a New Sulfonamide and Penicillin in the Treatment of Acute Streptococcal Pharyngitis , J Okla Med Assoc 57:7-10 ( (Jan) ) 1964. 14. Peters, J.H.: Treatment of Streptococcus Pyogenes Infections With a New Sulfonamide, 5-methyl-3-sulfanilamido-isoxazole , Antimicrob Agents Chemother ( (1961) ), pp 406-413, 1962. 15. Reichelderfer, T.E.: Clinical Studies and Therapeutic Use of Sulfamethoxazole in a Pediatric Out-Patient Clinic , Clin Med 71:1045-1055 ( (June) ) 1964. 16. Alban, J.: Treatment of β-Hemolytic Streptococcal Infection: A Study of the Pediatric Use of Sulfamethoxazole , Amer J Dis Child 109:304-307 ( (April) ) 1965.Crossref 17. Miller, J.M.; Stancer, S.L.; and Massell, B.F.: A Controlled Study of Beta Hemolytic Streptococcal Infection in Rheumatic Families: I. Streptococcal Disease Among Healthy Siblings , Amer J Med 25:825-844 ( (Dec) ) 1958.Crossref 18. Swift, H.F.; Wilson, A.T.; and Lancefield, R.C.: Typing Group A Hemolytic Streptococci by M Precipitin Reactions in Capillary Pipettes , J Exp Med 78:127-133 ( (Aug 1) ) 1943.Crossref 19. Massell, B.F.; Amezcua, J.; and Michael, J.G.: Home Cultures as an Aid in the Diagnosis of Streptococcal Respiratory Infection: Evaluation of the Filter-Paper Strip as a Transport Medium , New Eng J Med 271:581-585 ( (Sept 17) ) 1964.Crossref 20. Hill, A.B.: Principles of Medical Statistics , ed 5, London: The Lancet Ltd., 1950, p 139. 21. Fisher, R.A.: Statistical Methods for Research Workers , ed 10, Edinburgh: Oliver & Boyd Ltd., 1946, p 96. 22. Committee Report, American Heart Association, Prevention of Rheumatic Fever and Bacterial Endocarditis Through Control of Streptococcal Infections , Circulation 21:151-155 ( (Jan) ) 1960.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1969

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