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Treatment of Eczema Herpeticum With Acyclovir

Treatment of Eczema Herpeticum With Acyclovir Abstract • Eczema herpeticum is a serious herpes simplex virus infection that may have a fatal outcome. Effective antiviral therapy is therefore imperative. Acyclvoir (9-[2-hydroxyethoxymethyl]-guanine) is a new antiviral agent with high potency and low toxic effect. We treated three cases of eczema herpeticum successfully with acyclovir. (Arch Dermatol 1983;119:13-16) References 1. Hazen PG, Bennet-Epprs R: Eczema herpeticum caused by herpesvirus type 2 . Arch Dermatol 1977;113:1085-1086.Crossref 2. Wheeler CE, Abele DC, Hill C: Eczema herpeticum primary and recurrent . Arch Dermatol 1966;93:162-171.Crossref 3. Brian RT: The clinical vagaries of the herpes virus . Br Med J 1956;1:1061-1068.Crossref 4. Chang TW, Weinstein L: Eczema herpeticum treatment with methylene blue and light . Arch Dermatol 1975;11:1174-1175.Crossref 5. Juel-Jensen BE, MacCallum FO: Herpes Simplex, Varicella and Zoster . Philadelphia, JB Lippincott Co, 1972, pp 154-157. 6. Peters ACB, Versteeg J: Den Hartog-Jager Color Atlas of CSF Cytopathology . New York, Elsevier North Holland Inc, 1980. 7. Antiviral treatment of varicella, zoster and herpes simplex . Lancet 1980;1:1337-1339. 8. Hirsch MS, Swarts MN: Antiviral agents . N Engl J Med 1980;302:903-907, 949-953.Crossref 9. Whitley RJ, Soong S, Dolin R, et al: Adenine arabinoside therapy of biopsy proved herpes simples encephalitis . N Engl J Med 1977;297:289-294.Crossref 10. Taulbee KS, Johnson SC: Disseminated cutaneous herpes simplex infection in cutaneous T-cell lymphoma . Arch Dermatol 1981;117:114-115.Crossref 11. Schaeffer HJ, Beauchamp L, De Miranda P, et al: 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group . Nature 1978;272:583-585.Crossref 12. Pavan-Langston D, Campbell R, Lass J: Acyclic antimetabolite therapy for experimental herpes simplex keratitis . Am J Opthalmol 1978;86:618-623. 13. Elion GB, Furman PA, Fyfe JA, et al: Selectivity of action of an antiherpetic agent 9-(2-hydroxyethoxymethyl) guanine . Proc Natl Acad Sci USA 1977;74:5716-5720.Crossref 14. Oosterhuis JA, Versteeg J, Kruit PJ, et al: Acyclovir treatment in experimental herpetic keratitis in rabbits . Ophthalmic Res 1980;12:38-44.Crossref 15. Park NH, Pavan-Langston D, MacLean SL, et al: Therapy of experimental herpes simplex encephalitis with acyclovir in mice . Antimicrob Agents Chemother 1979;16:775-779.Crossref 16. Park NH, Pavan-Langston D, MacLean SL, et al: Acyclovir topical therapy of cutaneous herpes simplex virus infection in guinea pigs . Arch Dermatol 1980;116:672-675.Crossref 17. Van der Meer JWM, Thompson J, Tan WD, et al: Treatment of chickenpox pneumonia with acyclovir . Lancet 1980;2:473-474.Crossref 18. Selby PJ, Powles RL, Jameson B, et al: Parenteral acyclovir therapy for herpes virus infection in man . Lancet 1979;2:1267-1270.Crossref 19. Mitchell CD, Gentry SR, Boen JR, et al: Ayclovir therapy for mucocutaneous herpes simplex infections in immunocompromised patients . Lancet 1981;1:1389-1392.Crossref 20. Chou S, Gallagher JG, Merigan TC: Controlled clinical trial of intravenous acyclovir in heart-transplant patients with mucocutaneous herpes simplex infections . Lancet 1981;1:1392-1394.Crossref 21. Saral R, Burns WH, Laskin OL, et al: Acyclovir prophylaxis of herpes-simplex virus infections . N Engl J Med 1981;301:63-67.Crossref 22. Peterslund NA, Ippen J, Schonheyder H, et al: Acyclovir in herpes zoster . Lancet 1981;2:827-830.Crossref 23. Chapman JR, Bidgen D: Transient viral impairment during intravenous acyclovir therapy . Lancet 1981;2:1103.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650250017008
Publisher site
See Article on Publisher Site

Abstract

Abstract • Eczema herpeticum is a serious herpes simplex virus infection that may have a fatal outcome. Effective antiviral therapy is therefore imperative. Acyclvoir (9-[2-hydroxyethoxymethyl]-guanine) is a new antiviral agent with high potency and low toxic effect. We treated three cases of eczema herpeticum successfully with acyclovir. (Arch Dermatol 1983;119:13-16) References 1. Hazen PG, Bennet-Epprs R: Eczema herpeticum caused by herpesvirus type 2 . Arch Dermatol 1977;113:1085-1086.Crossref 2. Wheeler CE, Abele DC, Hill C: Eczema herpeticum primary and recurrent . Arch Dermatol 1966;93:162-171.Crossref 3. Brian RT: The clinical vagaries of the herpes virus . Br Med J 1956;1:1061-1068.Crossref 4. Chang TW, Weinstein L: Eczema herpeticum treatment with methylene blue and light . Arch Dermatol 1975;11:1174-1175.Crossref 5. Juel-Jensen BE, MacCallum FO: Herpes Simplex, Varicella and Zoster . Philadelphia, JB Lippincott Co, 1972, pp 154-157. 6. Peters ACB, Versteeg J: Den Hartog-Jager Color Atlas of CSF Cytopathology . New York, Elsevier North Holland Inc, 1980. 7. Antiviral treatment of varicella, zoster and herpes simplex . Lancet 1980;1:1337-1339. 8. Hirsch MS, Swarts MN: Antiviral agents . N Engl J Med 1980;302:903-907, 949-953.Crossref 9. Whitley RJ, Soong S, Dolin R, et al: Adenine arabinoside therapy of biopsy proved herpes simples encephalitis . N Engl J Med 1977;297:289-294.Crossref 10. Taulbee KS, Johnson SC: Disseminated cutaneous herpes simplex infection in cutaneous T-cell lymphoma . Arch Dermatol 1981;117:114-115.Crossref 11. Schaeffer HJ, Beauchamp L, De Miranda P, et al: 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group . Nature 1978;272:583-585.Crossref 12. Pavan-Langston D, Campbell R, Lass J: Acyclic antimetabolite therapy for experimental herpes simplex keratitis . Am J Opthalmol 1978;86:618-623. 13. Elion GB, Furman PA, Fyfe JA, et al: Selectivity of action of an antiherpetic agent 9-(2-hydroxyethoxymethyl) guanine . Proc Natl Acad Sci USA 1977;74:5716-5720.Crossref 14. Oosterhuis JA, Versteeg J, Kruit PJ, et al: Acyclovir treatment in experimental herpetic keratitis in rabbits . Ophthalmic Res 1980;12:38-44.Crossref 15. Park NH, Pavan-Langston D, MacLean SL, et al: Therapy of experimental herpes simplex encephalitis with acyclovir in mice . Antimicrob Agents Chemother 1979;16:775-779.Crossref 16. Park NH, Pavan-Langston D, MacLean SL, et al: Acyclovir topical therapy of cutaneous herpes simplex virus infection in guinea pigs . Arch Dermatol 1980;116:672-675.Crossref 17. Van der Meer JWM, Thompson J, Tan WD, et al: Treatment of chickenpox pneumonia with acyclovir . Lancet 1980;2:473-474.Crossref 18. Selby PJ, Powles RL, Jameson B, et al: Parenteral acyclovir therapy for herpes virus infection in man . Lancet 1979;2:1267-1270.Crossref 19. Mitchell CD, Gentry SR, Boen JR, et al: Ayclovir therapy for mucocutaneous herpes simplex infections in immunocompromised patients . Lancet 1981;1:1389-1392.Crossref 20. Chou S, Gallagher JG, Merigan TC: Controlled clinical trial of intravenous acyclovir in heart-transplant patients with mucocutaneous herpes simplex infections . Lancet 1981;1:1392-1394.Crossref 21. Saral R, Burns WH, Laskin OL, et al: Acyclovir prophylaxis of herpes-simplex virus infections . N Engl J Med 1981;301:63-67.Crossref 22. Peterslund NA, Ippen J, Schonheyder H, et al: Acyclovir in herpes zoster . Lancet 1981;2:827-830.Crossref 23. Chapman JR, Bidgen D: Transient viral impairment during intravenous acyclovir therapy . Lancet 1981;2:1103.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1983

References