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Treatment of Diabetes Insipidus with Synthetic Vasopressin

Treatment of Diabetes Insipidus with Synthetic Vasopressin THE CHRONIC NATURE of diabetes insipidus necessitates an indefinite course of treatment. Hormonal substitution is obviously the preferred form of therapy. Nevertheless some patients cannot tolerate the natural vasopressor substance or, for other reasons are unable to receive intramuscular injections of the hormone for months or years. The alternative nasal vasopressin frequently injures the nasal mucosa and may cause a distressing rhinorrhea. To overcome these difficulties other methods of treatment have been suggested. Aminopyrine and members of the chlorthiazide group have been found advantageous for short term therapy but their use is limited. A more suitable substance would be a vasopressin, relatively free of side effects, which could be administered by means other than injection. Such a preparation, 8-lysine vasopressin nasal spray, proved effective in a patient with diabetes insipidus who experienced generalized allergic reactions to the natural hormone. His favorable clinical response to the 8-lysine vasopressin nasal spray, a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Treatment of Diabetes Insipidus with Synthetic Vasopressin

JAMA , Volume 184 (8) – May 25, 1963

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1963.73700210020020a
Publisher site
See Article on Publisher Site

Abstract

THE CHRONIC NATURE of diabetes insipidus necessitates an indefinite course of treatment. Hormonal substitution is obviously the preferred form of therapy. Nevertheless some patients cannot tolerate the natural vasopressor substance or, for other reasons are unable to receive intramuscular injections of the hormone for months or years. The alternative nasal vasopressin frequently injures the nasal mucosa and may cause a distressing rhinorrhea. To overcome these difficulties other methods of treatment have been suggested. Aminopyrine and members of the chlorthiazide group have been found advantageous for short term therapy but their use is limited. A more suitable substance would be a vasopressin, relatively free of side effects, which could be administered by means other than injection. Such a preparation, 8-lysine vasopressin nasal spray, proved effective in a patient with diabetes insipidus who experienced generalized allergic reactions to the natural hormone. His favorable clinical response to the 8-lysine vasopressin nasal spray, a

Journal

JAMAAmerican Medical Association

Published: May 25, 1963

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