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TREATMENT OF DARIER'S DISEASE (KERATOSIS FOLLICULARIS)

TREATMENT OF DARIER'S DISEASE (KERATOSIS FOLLICULARIS) Abstract Treatment in many cases of Darier's disease (keratosis follicularis) has been unsatisfactory. Although vitamin A therapy as reported by Peck and associates1 is helpful, not all persons with the disease respond. It was in such a patient that the treatment of a daily bath with hypertonic saline solution, as advised by Gordon2 for ichthyosis, was tried. It has relieved the itching, removed most of the hyperkeratotic tissue, and controlled the severe outbreaks. REPORT OF A CASE J. C., aged 28, first had the eruption eight years ago. There was no family history of skin eruption. Biopsy confirmed the diagnosis of keratosis follicularis. He had been receiving large dosages of vitamin A, 100,000 to 200,000 units a day, in oil and aqueous preparations with and without polysorbate 80 (monitan®). Locally, sulfur and salicylic acid ointments, vitamin A ointments, and x-ray therapy had been used. The last produced References 1. Peck, S. M.; Glick, A. W., and Chargin, I.: Vitamin A Studies in Cases of Ichthyosis , Arch. Dermat. & Syph. 48:32-34 ( (July) ) 1943. 2. Gordon, H. H.: Treatment of Ichthyosis , Arch. Dermat. & Syph. 52:178-179 ( (Sept.) ) 1945. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

TREATMENT OF DARIER'S DISEASE (KERATOSIS FOLLICULARIS)

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TREATMENT OF DARIER'S DISEASE (KERATOSIS FOLLICULARIS)

Abstract

Abstract Treatment in many cases of Darier's disease (keratosis follicularis) has been unsatisfactory. Although vitamin A therapy as reported by Peck and associates1 is helpful, not all persons with the disease respond. It was in such a patient that the treatment of a daily bath with hypertonic saline solution, as advised by Gordon2 for ichthyosis, was tried. It has relieved the itching, removed most of the hyperkeratotic tissue, and controlled the severe outbreaks. REPORT OF A CASE J....
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1952.01530300074008
Publisher site
See Article on Publisher Site

Abstract

Abstract Treatment in many cases of Darier's disease (keratosis follicularis) has been unsatisfactory. Although vitamin A therapy as reported by Peck and associates1 is helpful, not all persons with the disease respond. It was in such a patient that the treatment of a daily bath with hypertonic saline solution, as advised by Gordon2 for ichthyosis, was tried. It has relieved the itching, removed most of the hyperkeratotic tissue, and controlled the severe outbreaks. REPORT OF A CASE J. C., aged 28, first had the eruption eight years ago. There was no family history of skin eruption. Biopsy confirmed the diagnosis of keratosis follicularis. He had been receiving large dosages of vitamin A, 100,000 to 200,000 units a day, in oil and aqueous preparations with and without polysorbate 80 (monitan®). Locally, sulfur and salicylic acid ointments, vitamin A ointments, and x-ray therapy had been used. The last produced References 1. Peck, S. M.; Glick, A. W., and Chargin, I.: Vitamin A Studies in Cases of Ichthyosis , Arch. Dermat. & Syph. 48:32-34 ( (July) ) 1943. 2. Gordon, H. H.: Treatment of Ichthyosis , Arch. Dermat. & Syph. 52:178-179 ( (Sept.) ) 1945.

Journal

A.M.A. Archives of Dermatology & Syphilology – American Medical Association

Published: Nov 1, 1952

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