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Treatment of Cutaneous Sarcoidosis With Isotretinoin

Treatment of Cutaneous Sarcoidosis With Isotretinoin Abstract • A patient with chronic cutaneous and pulmonary sarcoidosis, unresponsive to oral corticosteroid therapy, was treated with isotretinoin. The patient's cutaneous manifestations of sarcoidosis showed consistent improvement during the course of retinoid therapy. The lesions that responded earliest either resolved or showed the greatest reduction in size. The patient's WBC count increased and her angiotensin-converting enzyme level decreased during the first two months of isotretinoin therapy; both returned to pretreatment levels during the third month of therapy. Pulmonary function tests were unchanged after four months of treatment. isotretinoin may be a useful therapeutic agent for cutaneous sarcoidosis. However, the possibility of spontaneous remission of the disease during the course of therapy cannot be excluded. (Arch Dermatol 1983;119:1003-1005) References 1. Hanno R, Callen JP: Sarcoidosis . Med Clin North Am 1980;64:847-866. 2. Morse SI, Cohn ZA, Hirsch JG, et al: The treatment of sarcoidosis with chloroquine . Am J Med 1961;30:779-784.Crossref 3. Siltzbach LE, Teirstein AS: Chloroquine therapy in 43 patients with intrathoracic and cutaneous sarcoidosis . Acta Med Scand Suppl 1964;425:302-306. 4. Rosof BM: Allopurinol for sarcoid? N Engl J Med 1976; 294:447. 5. Veien NK, Brodthagen H: Cutaneous sarcoidosis treated with methotrexate . Br J Dermatol 1977;97:213-216.Crossref 6. Orfanos CE: Oral retinoids-present status . Br J Dermatol 1980;103:473-480.Crossref 7. James DG: Dermatological aspects of sarcoidosis . Q J Med 1959;28:109-124. 8. Jones M, Israel HL: Course and prognosis of sarcoidosis . Am J Med 1960;29:84-93.Crossref 9. DeRemee RA, Rohrbach MS: Serum angiotensin converting enzyme activity in evaluating the clincial course of sarcoidosis . Ann Intern Med 1980;92:361-364.Crossref 10. Elias PM, Williams ML: Retinoids, cancer, and the skin . Arch Dermatol 1981;117:160-180.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Treatment of Cutaneous Sarcoidosis With Isotretinoin

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650360049012
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient with chronic cutaneous and pulmonary sarcoidosis, unresponsive to oral corticosteroid therapy, was treated with isotretinoin. The patient's cutaneous manifestations of sarcoidosis showed consistent improvement during the course of retinoid therapy. The lesions that responded earliest either resolved or showed the greatest reduction in size. The patient's WBC count increased and her angiotensin-converting enzyme level decreased during the first two months of isotretinoin therapy; both returned to pretreatment levels during the third month of therapy. Pulmonary function tests were unchanged after four months of treatment. isotretinoin may be a useful therapeutic agent for cutaneous sarcoidosis. However, the possibility of spontaneous remission of the disease during the course of therapy cannot be excluded. (Arch Dermatol 1983;119:1003-1005) References 1. Hanno R, Callen JP: Sarcoidosis . Med Clin North Am 1980;64:847-866. 2. Morse SI, Cohn ZA, Hirsch JG, et al: The treatment of sarcoidosis with chloroquine . Am J Med 1961;30:779-784.Crossref 3. Siltzbach LE, Teirstein AS: Chloroquine therapy in 43 patients with intrathoracic and cutaneous sarcoidosis . Acta Med Scand Suppl 1964;425:302-306. 4. Rosof BM: Allopurinol for sarcoid? N Engl J Med 1976; 294:447. 5. Veien NK, Brodthagen H: Cutaneous sarcoidosis treated with methotrexate . Br J Dermatol 1977;97:213-216.Crossref 6. Orfanos CE: Oral retinoids-present status . Br J Dermatol 1980;103:473-480.Crossref 7. James DG: Dermatological aspects of sarcoidosis . Q J Med 1959;28:109-124. 8. Jones M, Israel HL: Course and prognosis of sarcoidosis . Am J Med 1960;29:84-93.Crossref 9. DeRemee RA, Rohrbach MS: Serum angiotensin converting enzyme activity in evaluating the clincial course of sarcoidosis . Ann Intern Med 1980;92:361-364.Crossref 10. Elias PM, Williams ML: Retinoids, cancer, and the skin . Arch Dermatol 1981;117:160-180.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1983

References