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Treatment of Bowen's Disease With Topical 5-Fluorouracil Under Occlusion

Treatment of Bowen's Disease With Topical 5-Fluorouracil Under Occlusion Abstract Therapy with topically administered 5-fluorouracil under occlusion proved remarkably successful in resolving a large protuberant 8 × 10-cm lesion of Bowen's disease on the thigh of an 83-year-old man. Within 12 days, the lesion had sloughed and by one month the epidermis had returned to normal. Further trials with this agent under occlusion are warranted for the treatment of superficial malignancies. References 1. Dillaha, C.T.; Jansen, G.T.; and Honeycutt, W.M.: Topical Therapy With Fluorouracil , Progr Derm 1:1, 1966. 2. Dillaha, C.J., et al: Selective Cytotoxic Effect of Topical 5-Fluorouracil , Arch Derm 88:247-256, 1963.Crossref 3. Dillaha, C.J., et al: Further Studies With Topical 5-Fluorouracil , Arch Derm 92:410-417, 1965.Crossref 4. Jansen, G.T.; Dillaha, C.T.; and Honeycutt, W.M.: Bowenoid Conditions of the Skin: Treatment With Topical 5-Fluorouracil , Southern Med J 60:185, 1967.Crossref 5. Klein, E., et al: Tumors of the Skin: V. Local Administration of Anti-Tumor Agents to Multiple Superficial Basal Cell Carcinomas , J Invest Derm 45:489-497, 1965.Crossref 6. Klein, E., et al: Tumors of the Skin: VI. Study on Effects of Local Administration of 5-Fluorouracil in Basal Cell Carcinoma , J Invest Derm 47:22-26, 1966.Crossref 7. Nurse, D.S.: Effect of Antimetabolites on Epidermal Structures , Arch Derm 87:258-265, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Treatment of Bowen's Disease With Topical 5-Fluorouracil Under Occlusion

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1968.01610080082016
Publisher site
See Article on Publisher Site

Abstract

Abstract Therapy with topically administered 5-fluorouracil under occlusion proved remarkably successful in resolving a large protuberant 8 × 10-cm lesion of Bowen's disease on the thigh of an 83-year-old man. Within 12 days, the lesion had sloughed and by one month the epidermis had returned to normal. Further trials with this agent under occlusion are warranted for the treatment of superficial malignancies. References 1. Dillaha, C.T.; Jansen, G.T.; and Honeycutt, W.M.: Topical Therapy With Fluorouracil , Progr Derm 1:1, 1966. 2. Dillaha, C.J., et al: Selective Cytotoxic Effect of Topical 5-Fluorouracil , Arch Derm 88:247-256, 1963.Crossref 3. Dillaha, C.J., et al: Further Studies With Topical 5-Fluorouracil , Arch Derm 92:410-417, 1965.Crossref 4. Jansen, G.T.; Dillaha, C.T.; and Honeycutt, W.M.: Bowenoid Conditions of the Skin: Treatment With Topical 5-Fluorouracil , Southern Med J 60:185, 1967.Crossref 5. Klein, E., et al: Tumors of the Skin: V. Local Administration of Anti-Tumor Agents to Multiple Superficial Basal Cell Carcinomas , J Invest Derm 45:489-497, 1965.Crossref 6. Klein, E., et al: Tumors of the Skin: VI. Study on Effects of Local Administration of 5-Fluorouracil in Basal Cell Carcinoma , J Invest Derm 47:22-26, 1966.Crossref 7. Nurse, D.S.: Effect of Antimetabolites on Epidermal Structures , Arch Derm 87:258-265, 1963.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1968

References