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Treatment of Behçet Disease With Chlorambucil: A Follow-Up Report

Treatment of Behçet Disease With Chlorambucil: A Follow-Up Report Abstract • In Behçet disease the eyes are involved in most cases, and progression to blindness is almost the rule. When the central nervous system is involved, the prognosis for life is grave. In a preliminary report, 11 patients had the disease arrested as a result of treatment with chlorambucil. Some of these patients had long-term follow-up and are included in this report. Nine others received the same treatment, resulting in arrest of the disease in eight and pronounced improvement in one. Long-term follow-up, in some patients for more than five years after arrest of the disease, has not disclosed any recurrence. These results may appear more important if it is noted that blindness in Behçet disease occurs an average of 3.36 years after onset of eye symptoms. References 1. Mamo JG, Azzam SA: Treatment of Behçet's disease with chlorambucil . Arch Ophthalmol 84:446-450, 1970.Crossref 2. Rosselet E, Saudan Y, Zenklusen G: Les effets de l'azathioprine (Imuran) dans la maladie de Behçet . Ophthalmologica 156:218-226, 1968.Crossref 3. Wong VG: Immunosuppressive therapy of ocular inflammatory diseases . Arch Ophthalmol 81:628-637, 1969.Crossref 4. Pivetti-Pezzi P, Bisantis C, Moschini GB, et al: La nostra esperienza sulla terapia immunosopressiva nella malattia di Behçet . Boll Oculist 48:886-895, 1969. 5. Buckley CE, Gills JP: Cyclophosphamide therapy of Behçet's disease . J Allergy 43:273, 1969.Crossref 6. Abdalla M, el-D Bahoat N: Long-lasting remission of Behçet's disease after chlorambucil therapy . Br J Ophthalmol 57:706-711, 1973.Crossref 7. Godfrey WA, Epstein WV, O'Connor GR, et al: The use of chlorambucil in intractable idiopathic uveitis . Am J Ophthalmol 78:415-428, 1974. 8. Mamo JG, Baghdassarian A: Behçet's disease: A report of 28 cases . Arch Ophthalmol 71:4-14, 1964.Crossref 9. Nazzaro P: Cutaneous manifestations of Behçet's disease: Nonspecific skin sensitivity , in Monacelli M, Nazzaro P (eds): Behçet's Disease . Basel, Switzerland, S. Karger, 1966, p 23. 10. Mamo JG: The rate of visual loss in Behçet's disease . Arch Ophthalmol 84:451-452, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Treatment of Behçet Disease With Chlorambucil: A Follow-Up Report

Archives of Ophthalmology , Volume 94 (4) – Apr 1, 1976

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1976.03910030274004
Publisher site
See Article on Publisher Site

Abstract

Abstract • In Behçet disease the eyes are involved in most cases, and progression to blindness is almost the rule. When the central nervous system is involved, the prognosis for life is grave. In a preliminary report, 11 patients had the disease arrested as a result of treatment with chlorambucil. Some of these patients had long-term follow-up and are included in this report. Nine others received the same treatment, resulting in arrest of the disease in eight and pronounced improvement in one. Long-term follow-up, in some patients for more than five years after arrest of the disease, has not disclosed any recurrence. These results may appear more important if it is noted that blindness in Behçet disease occurs an average of 3.36 years after onset of eye symptoms. References 1. Mamo JG, Azzam SA: Treatment of Behçet's disease with chlorambucil . Arch Ophthalmol 84:446-450, 1970.Crossref 2. Rosselet E, Saudan Y, Zenklusen G: Les effets de l'azathioprine (Imuran) dans la maladie de Behçet . Ophthalmologica 156:218-226, 1968.Crossref 3. Wong VG: Immunosuppressive therapy of ocular inflammatory diseases . Arch Ophthalmol 81:628-637, 1969.Crossref 4. Pivetti-Pezzi P, Bisantis C, Moschini GB, et al: La nostra esperienza sulla terapia immunosopressiva nella malattia di Behçet . Boll Oculist 48:886-895, 1969. 5. Buckley CE, Gills JP: Cyclophosphamide therapy of Behçet's disease . J Allergy 43:273, 1969.Crossref 6. Abdalla M, el-D Bahoat N: Long-lasting remission of Behçet's disease after chlorambucil therapy . Br J Ophthalmol 57:706-711, 1973.Crossref 7. Godfrey WA, Epstein WV, O'Connor GR, et al: The use of chlorambucil in intractable idiopathic uveitis . Am J Ophthalmol 78:415-428, 1974. 8. Mamo JG, Baghdassarian A: Behçet's disease: A report of 28 cases . Arch Ophthalmol 71:4-14, 1964.Crossref 9. Nazzaro P: Cutaneous manifestations of Behçet's disease: Nonspecific skin sensitivity , in Monacelli M, Nazzaro P (eds): Behçet's Disease . Basel, Switzerland, S. Karger, 1966, p 23. 10. Mamo JG: The rate of visual loss in Behçet's disease . Arch Ophthalmol 84:451-452, 1970.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1976

References