Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Treatment of Atopic Dermatitis With Topically Applied Caffeine

Treatment of Atopic Dermatitis With Topically Applied Caffeine Abstract To the Editor.— Locally applied B-adrenergic agents suppress the immediate skin test reaction in atopic patients, presumably by increasing skin levels of cyclic adenosine monophosphate.1 Caffeine, a methylxanthine, increases cyclic adenosine monophosphate by inhibiting cyclic nucleotide phosphodiesterase, the enzyme that degrades cyclic adenosine monophosphate. It seemed to us that using topical caffeine to increase skin levels of cyclic adenosine monophosphate might lessen the symptoms of atopic dermatitis.Patients with the typical flexural crease manifestations of atopic dermatitis were selected. The purpose of the study was explained to all patients, and written consent was obtained. Each patient was instructed to apply a cream labeled "R" to the right-sided lesions three times a day and at night, and to apply a cream labeled "L" to the left-sided lesions three times a day and at night. One side was treated with caffeine, 10%, in hydrophilic base, and the other side References 1. Shereff RH, Harwell W, Lieberman P, et al: Effect of B-adrenergic stimulation and blockade on immediate hypersensitivity skin test reactions . J Allergy Clin Immunol 52:328, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Treatment of Atopic Dermatitis With Topically Applied Caffeine

Loading next page...
 
/lp/american-medical-association/treatment-of-atopic-dermatitis-with-topically-applied-caffeine-q3NdMO3RAC
Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630300076020
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Locally applied B-adrenergic agents suppress the immediate skin test reaction in atopic patients, presumably by increasing skin levels of cyclic adenosine monophosphate.1 Caffeine, a methylxanthine, increases cyclic adenosine monophosphate by inhibiting cyclic nucleotide phosphodiesterase, the enzyme that degrades cyclic adenosine monophosphate. It seemed to us that using topical caffeine to increase skin levels of cyclic adenosine monophosphate might lessen the symptoms of atopic dermatitis.Patients with the typical flexural crease manifestations of atopic dermatitis were selected. The purpose of the study was explained to all patients, and written consent was obtained. Each patient was instructed to apply a cream labeled "R" to the right-sided lesions three times a day and at night, and to apply a cream labeled "L" to the left-sided lesions three times a day and at night. One side was treated with caffeine, 10%, in hydrophilic base, and the other side References 1. Shereff RH, Harwell W, Lieberman P, et al: Effect of B-adrenergic stimulation and blockade on immediate hypersensitivity skin test reactions . J Allergy Clin Immunol 52:328, 1973.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1976

References