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TREATMENT OF ADDISON'S DISEASE

TREATMENT OF ADDISON'S DISEASE Abstract ONE HUNDRED years has elapsed since Thomas Addison published his epochal report "On the Constitutional and Local Effects of Disease of the Suprarenal Capsules."1 The remarkable progress of medical science in the past century is in no way better exemplified than by the advances that have been made in our knowledge of the effects and the treatment of adrenal insufficiency. Although there is still much to be learned of the normal and pathological physiology of the adrenal glands, from the practical viewpoint of therapy their destruction or removal no longer presents a danger to life or even to normal health. These advances have been made possible by a remarkable series of collaborative enterprises among biochemists, physiologists, and physicians during the past 30 years. Prior to this era of collaboration attention had been directed principally to the development of extracts of adrenal glands to provide replacement therapy. Sir William Osler, References 1. Addison, T.: On the Constitutional and Local Effects of Disease of the Suprarenal Capsules , London, D. Highley, 1855. 2. Osler, W.: On 6 Cases of Addison's Disease, with the Report of a Case Greatly Benefited by the Use of Suprarenal Extract , Internat. M. Magazine 5:3, 1896. 3. Hartman, F. A.; MacArthur, C. G., and Hartman, W. E.: A Substance Which Prolongs the Life of Adrenalectomized Cats , Proc. Soc. Exper. Biol. & Med. 25:69, 1927. 4. Rogoff, J. M., and Stewart, G. N.: The Influence of Adrenal Extracts on the Survival Period of Adrenalectomized Dogs , Science 66:327, 1927. 5. Swingle, W. W., and Pfiffner, J. J.: An Aqueous Extract of the Suprarenal Cortex Which Maintains the Life of Bilaterally Adrenalectomized Cats , Science 71:321, 1930. 6. Loeb, R. F.: Effect of Sodium Chloride in Treatment of Patient with Addison's Disease , Proc. Soc. Exper. Biol. & Med. 30:808, 1933. 7. Harrop, G. A.; Weinstein, A.; Soffer, L. J., and Trescher, J. H.: Diagnosis and Treatment of Addison's Disease , J.A.M.A. 100:1850, 1933. 8. Steiger, M., and Reichstein, T.: Desoxy-Cortico-Steron (21-Oxy-Progesteron) aus △ 5-3Oxy-Atio-Cholensaure , Helvet. chim. acta 20:1164, 1937. 9. Kendall, E. C.; Mason, H. L.; Hoehn, W. M., and McKenzie, B. F.: Studies in Chemistry of Suprarenal Cortex: Structure and Physiologic Activity of Compound B: Its Relation to Compound A and Reichstein's Corticosterone , Proc. Staff Meet. Mayo Clin. 12:136, 1937. 10. Goldfien, A.; Laidlaw, J. C.; Haydar, N. A.; Renold, A. E., and Thorn, G. W.: Fluorohydrocortisone and Chlorohydrocortisone, Highly Potent Derivatives of Compound F , New England J. Med. 252:415-421, 1955. 11. Thorn, G. W.; Forsham, P. H.; Frawley, T. F.; Wilson, D. L.; Renold, A. E.; Fredrickson, D. S., and Jenkins, D.: Advances in the Diagnosis and Treatment of Adrenal Insufficiency , Am. J. Med. 10:595, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

TREATMENT OF ADDISON'S DISEASE

A.M.A. Archives of Internal Medicine , Volume 98 (1) – Jul 1, 1956

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1956.00250250106014
Publisher site
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Abstract

Abstract ONE HUNDRED years has elapsed since Thomas Addison published his epochal report "On the Constitutional and Local Effects of Disease of the Suprarenal Capsules."1 The remarkable progress of medical science in the past century is in no way better exemplified than by the advances that have been made in our knowledge of the effects and the treatment of adrenal insufficiency. Although there is still much to be learned of the normal and pathological physiology of the adrenal glands, from the practical viewpoint of therapy their destruction or removal no longer presents a danger to life or even to normal health. These advances have been made possible by a remarkable series of collaborative enterprises among biochemists, physiologists, and physicians during the past 30 years. Prior to this era of collaboration attention had been directed principally to the development of extracts of adrenal glands to provide replacement therapy. Sir William Osler, References 1. Addison, T.: On the Constitutional and Local Effects of Disease of the Suprarenal Capsules , London, D. Highley, 1855. 2. Osler, W.: On 6 Cases of Addison's Disease, with the Report of a Case Greatly Benefited by the Use of Suprarenal Extract , Internat. M. Magazine 5:3, 1896. 3. Hartman, F. A.; MacArthur, C. G., and Hartman, W. E.: A Substance Which Prolongs the Life of Adrenalectomized Cats , Proc. Soc. Exper. Biol. & Med. 25:69, 1927. 4. Rogoff, J. M., and Stewart, G. N.: The Influence of Adrenal Extracts on the Survival Period of Adrenalectomized Dogs , Science 66:327, 1927. 5. Swingle, W. W., and Pfiffner, J. J.: An Aqueous Extract of the Suprarenal Cortex Which Maintains the Life of Bilaterally Adrenalectomized Cats , Science 71:321, 1930. 6. Loeb, R. F.: Effect of Sodium Chloride in Treatment of Patient with Addison's Disease , Proc. Soc. Exper. Biol. & Med. 30:808, 1933. 7. Harrop, G. A.; Weinstein, A.; Soffer, L. J., and Trescher, J. H.: Diagnosis and Treatment of Addison's Disease , J.A.M.A. 100:1850, 1933. 8. Steiger, M., and Reichstein, T.: Desoxy-Cortico-Steron (21-Oxy-Progesteron) aus △ 5-3Oxy-Atio-Cholensaure , Helvet. chim. acta 20:1164, 1937. 9. Kendall, E. C.; Mason, H. L.; Hoehn, W. M., and McKenzie, B. F.: Studies in Chemistry of Suprarenal Cortex: Structure and Physiologic Activity of Compound B: Its Relation to Compound A and Reichstein's Corticosterone , Proc. Staff Meet. Mayo Clin. 12:136, 1937. 10. Goldfien, A.; Laidlaw, J. C.; Haydar, N. A.; Renold, A. E., and Thorn, G. W.: Fluorohydrocortisone and Chlorohydrocortisone, Highly Potent Derivatives of Compound F , New England J. Med. 252:415-421, 1955. 11. Thorn, G. W.; Forsham, P. H.; Frawley, T. F.; Wilson, D. L.; Renold, A. E.; Fredrickson, D. S., and Jenkins, D.: Advances in the Diagnosis and Treatment of Adrenal Insufficiency , Am. J. Med. 10:595, 1951.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Jul 1, 1956

References