I read the article by Gordon et al1 with great interest. I agree that further studies are necessary to assess the safety and efficacy of combinations of chelating agents in humans. In a rat model, Flora et al2 found that the combined regimen of calcium disodium EDTA and meso-2,3 dimercaptosuccinic acid elicited a greater urinary lead elimination and a lower blood lead level than either agent alone. However, the combined regimen was associated with an elevation of the serum transaminase and creatinine levels. Did Gordon et al monitor renal and hepatic functions during the treatment of their patient? If so, were abnormalities noted? References 1. Gordon RARoberts GAmin ZWilliams RHPaloucek FP Aggressive approach in the treatment of acute lead encephalopathy with an extraordinarily high concentration of lead. Arch Pediatr Adolesc Med. 1998;1521100- 1104Google ScholarCrossref 2. Flora SJSBhattacharya RVijayaraghavan R Combined therapeutic potential of meso-2,3 dimercaptosuccinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats. Fundam Appl Toxicol. 1995;25233- 240Google ScholarCrossref
Archives of Pediatrics & Adolescent Medicine – American Medical Association
Published: Nov 1, 1999
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