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Treatment and Prophylaxis Failure of Erythromycin in Pertussis

Treatment and Prophylaxis Failure of Erythromycin in Pertussis Abstract Sir.—The report by Halsey and associates (Journal 134:521-522, 1980) deserves critical review. They observed an infant with clinical pertussis, the culture being positive; after only seven days of erythromycin therapy, the infant was found on the eighth day to have a positive culture for Bordetella pertussis. The fluorescent antibody (FA) test on the same sample was negative. This does not necessarily indicate an erythromycin treatment failure. Short courses of erythromycin are often followed by bacteriologic relapse. We observed such a relapse in the first of ten patients treated with erythromycin in our study of pertussis.1 This patient had negative culture and FA test after 48 hours of treatment. She was treated for ten days, and one day after stopping erythromycin therapy she again had positive culture and FA test; this persisted for four days. We did not (and have not since) observed a bacteriologic relapse in patients treated for References 1. Bass JW, Klenk EL, Kotheimer JB, et al: Antimicrobial treatment of pertussis . J Pediatr 75:768-781, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Treatment and Prophylaxis Failure of Erythromycin in Pertussis

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130240058022
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—The report by Halsey and associates (Journal 134:521-522, 1980) deserves critical review. They observed an infant with clinical pertussis, the culture being positive; after only seven days of erythromycin therapy, the infant was found on the eighth day to have a positive culture for Bordetella pertussis. The fluorescent antibody (FA) test on the same sample was negative. This does not necessarily indicate an erythromycin treatment failure. Short courses of erythromycin are often followed by bacteriologic relapse. We observed such a relapse in the first of ten patients treated with erythromycin in our study of pertussis.1 This patient had negative culture and FA test after 48 hours of treatment. She was treated for ten days, and one day after stopping erythromycin therapy she again had positive culture and FA test; this persisted for four days. We did not (and have not since) observed a bacteriologic relapse in patients treated for References 1. Bass JW, Klenk EL, Kotheimer JB, et al: Antimicrobial treatment of pertussis . J Pediatr 75:768-781, 1969.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Dec 1, 1980

References