Abstract Experimental, superficial, streptococcal cutaneous infections were produced by repeated stripping of the skin of hairless mice before inoculation with a broth containing streptococci. Fifteen or more strippings were necessary to produce a crusted lesion. Pathological examination of biopsies taken from the denuded skin of mice inoculated with live streptococci immediately after stripping, showed that the bacteria delayed the process of reepithelialization in the stripped wound. References 1. Jackson Memorial Laboratories, Bar Harbor, Me. 2. Albini Laboratories, Brooklyn, NY. 3. Schwab, J. H., and Cromartie, W. J.: Studies on a Toxic Cellular Component of Group A Streptococci , J Bact 74:673-679, 1957. 4. Krasner, R. I., and Young, G.: Role of Hyaluronidase and the Hyaluronic Acid Capsule in the Survival and Dissemination of Group A Streptococci in the Hamster Cheek Pouch , J Bact 76:349-354, 1958.Crossref 5. Miles, A. A.; Miles, E. M.; and Burke, J.: The Value and Duration of Defence Reactions of the Skin to the Primary Lodgement of Bacteria , Brit J Exp Path 38:79-96, 1957. 6. Miles, A. A., and Miles, E. M.: The State of Lymphatic Capillaries in Acute Inflammatory Lesions , J Path Bact 76:21-35, 1958.Crossref 7. Eagle, H.; Fleischman, R.; and Levy, M.: Continuous vs Discontinuous Therapy With Penicillin: The Effect of the Interval Between Injections in Therapeutic Efficacy , New Eng J Med 248:481-488, 1953.Crossref 8. Eagle, H.: Experimental Approach to the Problem of Treatment Failure With Penicillin: I. Group A Streptococcal Infection in Mice , Amer J Med 13:389-399, 1952.Crossref 9. Wolf, J.: Das Oberfläscherelief der Menlischen Haut , Z Mikr anat Forsch 47:351-400, 1940. 10. Pinkus, H.: Examination of the Epidermis by the Strip Method of Removing Horny Layers: I. Observations on Thickness of the Horny Layer, and on Mitotic Activity After Stripping , J Invest Derm 16:383-386, 1951.
Archives of Dermatology – American Medical Association
Published: Sep 1, 1963