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Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa

Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa Abstract • The function of the blood-retinal barrier was assessed by vitreous fluorophotometry in 12 patients with various genetic types of retinitis pigmentosa and in 11 normal subjects. The measurements were corrected to minimize the effect of artifacts. We evaluated the inward penetration of fluorescein sodium across the blood-retinal barrier and determined the outward permeability coefficient for fluorescein by interpreting the data with a pharmacokinetic computer model. Patients with retinitis pigmentosa had increased inward permeability and decreased outward permeability to fluorescein in comparison with values of normal subjects. References 1. Cunha-Vaz JG: The blood-ocular barriers . Surv Ophthalmol 1979;23:279-296.Crossref 2. Cunha-Vaz JG: Vitreous fluorophotometry , in Cunha-Vaz JG (ed): The Blood-Retinal Barriers . New York, Plenum Press, 1980, pp 195-210. 3. Cunha-Vaz JG, Goldberg MF, Vygantas C, et al: Early detection of retinal involvement in diabetes by vitreous fluorophotometry . Ophthalmology 1979;86:264-275.Crossref 4. Braude LS, Cunha-Vaz JG, Goldberg MF, et al: Diagnosing acute retrobulbar neuritis by vitreous fluorophotometry . Am J Ophthalmol 1981; 91:764-773. 5. Mahlberg PA, Cunha-Vaz JG, Tessler HH: Vitreous fluorophotometry in pars planitis . Am J Ophthalmol 1983;95:189-196.Crossref 6. Jampol LM, White S, Cunha-Vaz JG: Vitreous fluorophotometry in patients with hypertension . Arch Ophthalmol 1983;101:888-890.Crossref 7. Gieser DK, Fishman GA, Cunha-Vaz JG: X-linked recessive retinitis pigmentosa and vitreous fluorophotometry: A study of female heterozygotes . Arch Ophthalmol 1980;98:307-310.Crossref 8. Fishman GA, Cunha-Vaz JG: Carriers of X-linked recessive retinitis pigmentosa: Investigation by vitreous fluorophotometry . Int Ophthalmol 1981;4:37-44.Crossref 9. Fishman GA, Cunha-Vaz JG, Salzano T: Vitreous fluorophotometry in patients with retinitis pigmentosa . Arch Ophthalmol 1981;99:1202-1207.Crossref 10. Brooks AMV: Experiences with fluorophotometry . Aust J Ophthalmol 1982;10:41-51.Crossref 11. Fishman GA, Cunha-Vaz JG, Travassos AC: Vitreous fluorophotometry in patients with fundus flavimaculatus . Arch Ophthalmol 1982; 100:1086-1088.Crossref 12. Miyake Y, Gto S, Ando F, et al: Vitreous fluorophotometry in congenital stationary night blindness . Arch Ophthalmol 1983;101:574-576.Crossref 13. Jones CW, Cunha-Vaz JG, Zweig KO, et al: Kinetic vitreous fluorophotometry in experimental diabetes . Arch Ophthalmol 1979;97:1941-1943.Crossref 14. Zweig K, Cunha-Vaz JG, Peyman G, et al: Effect of argon laser photocoagulation on fluorescein transport across the blood-retinal barrier . Exp Eye Res 1981;32:323-329.Crossref 15. Anstadt B, Blair NP, Rusin M, et al: Alteration of the blood-retinal barrier by sodium iodate: Kinetic vitreous fluorophotometry and horseradish peroxidase studies . Exp Eye Res 1982;35:653-662.Crossref 16. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: I. Description and evaluation of a new fluorophotometer . Arch Ophthalmol 1983;101:1753-1756.Crossref 17. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: II. Methodology of data acquisition and processing . Arch Ophthalmol 1983;101:1757-1761.Crossref 18. Mota MC, Gray JR, Leite E, et al: Studies on fluorescein concentration decay in human plasma , abstracted. Invest Ophthalmol Vis Sci 1983;24 ( (suppl) ):250. 19. Zeimer RC, Blair NP, Cunha-Vaz JG: Pharmacokinetic interpretation of vitreous fluorophotometry . Invest Ophthalmol Vis Sci 1983; 24:1374-1381. 20. Sokal RR, Rohlf FJ: Nested analysis of variance , in Biometry: The Principles and Practice of Statistics in Biological Research , ed 2. San Francisco, WH Freeman & Co, 1981, pp 271-320. 21. Prager TC, Chu HH, Garcia CA, et al: The influence of vitreous change on vitreous fluorophotometry . Arch Ophthalmol 1982;100:594-596.Crossref 22. Yoshida A, Furukawa H, Delori FC, et al: Effect of vitreous detachment on vitreous fluorophotometry , abstracted. Invest Ophthalmol Vis Sci 1983;24 ( (suppl) ):210. 23. Caldwell RB, McLaughlin BJ, Boykins LG: Intramembrane changes in retinal pigment epithelial cell junctions of the dystrophic rat retina . Invest Ophthalmol Vis Sci 1982;23:305-318. 24. Caldwell RB, McLaughlin BJ: Permeability of retinal pigment epithelial cell junctions in the dystrophic rat retina . Exp Eye Res 1983;36:415-427.Crossref 25. Essner E, Pino RM, Griewski RA: Breakdown of blood retinal barrier in RCS rats with inherited retinal degeneration . Lab Invest 1980; 43:418-426. 26. Palestine AG, Brubaker RF: Pharmacokinetics of fluorescein in the vitreous . Invest Ophthalmol Vis Sci 1981;21:542-549. 27. Blair NP, Zeimer RC, Rusin MM, et al: Outward transport of fluorescein from the vitreous in normal human subjects . Arch Ophthalmol 1983;101:1117-1121.Crossref 28. Cunha-Vaz JG, Maurice DM: The active transport of fluorescein by the retinal vessels and the retina . J Physiol 1967;191:467-486. 29. Irish JM III, Grantham JJ: Renal handling of organic anions and cations , in Brenner BM, Rector FC Jr (eds): The Kidney , ed 2. Philadelphia, WB Saunders Co, 1981, pp 619-649. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030547013
Publisher site
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Abstract

Abstract • The function of the blood-retinal barrier was assessed by vitreous fluorophotometry in 12 patients with various genetic types of retinitis pigmentosa and in 11 normal subjects. The measurements were corrected to minimize the effect of artifacts. We evaluated the inward penetration of fluorescein sodium across the blood-retinal barrier and determined the outward permeability coefficient for fluorescein by interpreting the data with a pharmacokinetic computer model. Patients with retinitis pigmentosa had increased inward permeability and decreased outward permeability to fluorescein in comparison with values of normal subjects. References 1. Cunha-Vaz JG: The blood-ocular barriers . Surv Ophthalmol 1979;23:279-296.Crossref 2. Cunha-Vaz JG: Vitreous fluorophotometry , in Cunha-Vaz JG (ed): The Blood-Retinal Barriers . New York, Plenum Press, 1980, pp 195-210. 3. Cunha-Vaz JG, Goldberg MF, Vygantas C, et al: Early detection of retinal involvement in diabetes by vitreous fluorophotometry . Ophthalmology 1979;86:264-275.Crossref 4. Braude LS, Cunha-Vaz JG, Goldberg MF, et al: Diagnosing acute retrobulbar neuritis by vitreous fluorophotometry . Am J Ophthalmol 1981; 91:764-773. 5. Mahlberg PA, Cunha-Vaz JG, Tessler HH: Vitreous fluorophotometry in pars planitis . Am J Ophthalmol 1983;95:189-196.Crossref 6. Jampol LM, White S, Cunha-Vaz JG: Vitreous fluorophotometry in patients with hypertension . Arch Ophthalmol 1983;101:888-890.Crossref 7. Gieser DK, Fishman GA, Cunha-Vaz JG: X-linked recessive retinitis pigmentosa and vitreous fluorophotometry: A study of female heterozygotes . Arch Ophthalmol 1980;98:307-310.Crossref 8. Fishman GA, Cunha-Vaz JG: Carriers of X-linked recessive retinitis pigmentosa: Investigation by vitreous fluorophotometry . Int Ophthalmol 1981;4:37-44.Crossref 9. Fishman GA, Cunha-Vaz JG, Salzano T: Vitreous fluorophotometry in patients with retinitis pigmentosa . Arch Ophthalmol 1981;99:1202-1207.Crossref 10. Brooks AMV: Experiences with fluorophotometry . Aust J Ophthalmol 1982;10:41-51.Crossref 11. Fishman GA, Cunha-Vaz JG, Travassos AC: Vitreous fluorophotometry in patients with fundus flavimaculatus . Arch Ophthalmol 1982; 100:1086-1088.Crossref 12. Miyake Y, Gto S, Ando F, et al: Vitreous fluorophotometry in congenital stationary night blindness . Arch Ophthalmol 1983;101:574-576.Crossref 13. Jones CW, Cunha-Vaz JG, Zweig KO, et al: Kinetic vitreous fluorophotometry in experimental diabetes . Arch Ophthalmol 1979;97:1941-1943.Crossref 14. Zweig K, Cunha-Vaz JG, Peyman G, et al: Effect of argon laser photocoagulation on fluorescein transport across the blood-retinal barrier . Exp Eye Res 1981;32:323-329.Crossref 15. Anstadt B, Blair NP, Rusin M, et al: Alteration of the blood-retinal barrier by sodium iodate: Kinetic vitreous fluorophotometry and horseradish peroxidase studies . Exp Eye Res 1982;35:653-662.Crossref 16. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: I. Description and evaluation of a new fluorophotometer . Arch Ophthalmol 1983;101:1753-1756.Crossref 17. Zeimer RC, Blair NP, Cunha-Vaz JG: Vitreous fluorophotometry for clinical research: II. Methodology of data acquisition and processing . Arch Ophthalmol 1983;101:1757-1761.Crossref 18. Mota MC, Gray JR, Leite E, et al: Studies on fluorescein concentration decay in human plasma , abstracted. Invest Ophthalmol Vis Sci 1983;24 ( (suppl) ):250. 19. Zeimer RC, Blair NP, Cunha-Vaz JG: Pharmacokinetic interpretation of vitreous fluorophotometry . Invest Ophthalmol Vis Sci 1983; 24:1374-1381. 20. Sokal RR, Rohlf FJ: Nested analysis of variance , in Biometry: The Principles and Practice of Statistics in Biological Research , ed 2. San Francisco, WH Freeman & Co, 1981, pp 271-320. 21. Prager TC, Chu HH, Garcia CA, et al: The influence of vitreous change on vitreous fluorophotometry . Arch Ophthalmol 1982;100:594-596.Crossref 22. Yoshida A, Furukawa H, Delori FC, et al: Effect of vitreous detachment on vitreous fluorophotometry , abstracted. Invest Ophthalmol Vis Sci 1983;24 ( (suppl) ):210. 23. Caldwell RB, McLaughlin BJ, Boykins LG: Intramembrane changes in retinal pigment epithelial cell junctions of the dystrophic rat retina . Invest Ophthalmol Vis Sci 1982;23:305-318. 24. Caldwell RB, McLaughlin BJ: Permeability of retinal pigment epithelial cell junctions in the dystrophic rat retina . Exp Eye Res 1983;36:415-427.Crossref 25. Essner E, Pino RM, Griewski RA: Breakdown of blood retinal barrier in RCS rats with inherited retinal degeneration . Lab Invest 1980; 43:418-426. 26. Palestine AG, Brubaker RF: Pharmacokinetics of fluorescein in the vitreous . Invest Ophthalmol Vis Sci 1981;21:542-549. 27. Blair NP, Zeimer RC, Rusin MM, et al: Outward transport of fluorescein from the vitreous in normal human subjects . Arch Ophthalmol 1983;101:1117-1121.Crossref 28. Cunha-Vaz JG, Maurice DM: The active transport of fluorescein by the retinal vessels and the retina . J Physiol 1967;191:467-486. 29. Irish JM III, Grantham JJ: Renal handling of organic anions and cations , in Brenner BM, Rector FC Jr (eds): The Kidney , ed 2. Philadelphia, WB Saunders Co, 1981, pp 619-649.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1984

References