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Transient Thyroid Suppression Associated With Topically Applied Povidone-Iodine

Transient Thyroid Suppression Associated With Topically Applied Povidone-Iodine Abstract The value of neonatal thyroid-screening programs is in the early detection of hypothyroidism due to a variety of causes.1 However, thyroid suppression associated with topical iodine applications has not been reported in any review of thyroid screening, to the best of our knowledge. Report of a Case.—An infant boy was born at term, weighing 2.9 kg, to nonconsanguineous parents. The mother had had a normal pregnancy and had not taken any medications. There was no family history of thyroid disease. The baby fed poorly, and on the second day passed several brownish, blood-stained stools. He had a tender, distended, edematous abdomen. Abdominal roentgenogram showed air in the intestinal wall, and necrotizing enterocolitis was diagnosed. On the third day, during laparotomy, the descending colon was perforated and an ileostomy was performed. At 8 days of age, the abdominal wound broke down; at 10 days, povidone-iodine (Betadine) was applied topically References 1. Dussault JH, Mitchell ML, LaFranchi S, et al: Regional screening for congenital hypothyroidism: Results of screening 1 million North American infants with filter paper spot T4-TSH , in Burrow GN, Dussault JH (eds): Neonatal Thyroid Screening . New York, Raven Press, 1980, pp 155-165. 2. Chabrolle JP, Rossier A: Transient neonatal hypothyroidism . Pediatrics 1978;62:857. 3. Hulse JA, Grant DB, Clayton BE, et al: Population screening for congenital hypothyroidism . Br Med J 1980;1:675-678.Crossref 4. Pyati SP, Ramamurthy RS, Krauss MT, et al: Absorption of iodine in the neonate following topical use of povidone iodine . J Pediatr 1977;91:825-828.Crossref 5. Prager EM, Gardner RE: Iatrogenic hypothyroidism from topical iodine-containing medications . West J Med 1979;130:553-555. 6. Lavelle KJ, Doedens DJ, Kleit SA, et al: Iodine absorption in burn patients treated topically with povidone-iodine . Clin Pharmacol Ther 1975;17:355-362. 7. King IR, Diddle AW: Protein-bound iodine and T4 tests after vaginal application of povidone-iodine containing medications . Am J Obstet Gynecol 1970;108:1175-1177. 8. Chabrolle JP, Rossier A: Goiter and hypothyroidism in the newborn after cutaneous absorption of iodine . Arch Dis Child 1978;53:495-498.Crossref 9. Higgins HP, Hawks GH, O'Sullivan M, et al: The effect of povidone-iodine on serum protein-bound iodine, when used as a surgical preparation on intact skin . Can Med Assoc J 1964;90:1298-1300. 10. Wolff J: Iodide goiter and the pharmacologic effects of excess iodine . Am J Med 1969;47:101-124.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Transient Thyroid Suppression Associated With Topically Applied Povidone-Iodine

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1982.03970400087025
Publisher site
See Article on Publisher Site

Abstract

Abstract The value of neonatal thyroid-screening programs is in the early detection of hypothyroidism due to a variety of causes.1 However, thyroid suppression associated with topical iodine applications has not been reported in any review of thyroid screening, to the best of our knowledge. Report of a Case.—An infant boy was born at term, weighing 2.9 kg, to nonconsanguineous parents. The mother had had a normal pregnancy and had not taken any medications. There was no family history of thyroid disease. The baby fed poorly, and on the second day passed several brownish, blood-stained stools. He had a tender, distended, edematous abdomen. Abdominal roentgenogram showed air in the intestinal wall, and necrotizing enterocolitis was diagnosed. On the third day, during laparotomy, the descending colon was perforated and an ileostomy was performed. At 8 days of age, the abdominal wound broke down; at 10 days, povidone-iodine (Betadine) was applied topically References 1. Dussault JH, Mitchell ML, LaFranchi S, et al: Regional screening for congenital hypothyroidism: Results of screening 1 million North American infants with filter paper spot T4-TSH , in Burrow GN, Dussault JH (eds): Neonatal Thyroid Screening . New York, Raven Press, 1980, pp 155-165. 2. Chabrolle JP, Rossier A: Transient neonatal hypothyroidism . Pediatrics 1978;62:857. 3. Hulse JA, Grant DB, Clayton BE, et al: Population screening for congenital hypothyroidism . Br Med J 1980;1:675-678.Crossref 4. Pyati SP, Ramamurthy RS, Krauss MT, et al: Absorption of iodine in the neonate following topical use of povidone iodine . J Pediatr 1977;91:825-828.Crossref 5. Prager EM, Gardner RE: Iatrogenic hypothyroidism from topical iodine-containing medications . West J Med 1979;130:553-555. 6. Lavelle KJ, Doedens DJ, Kleit SA, et al: Iodine absorption in burn patients treated topically with povidone-iodine . Clin Pharmacol Ther 1975;17:355-362. 7. King IR, Diddle AW: Protein-bound iodine and T4 tests after vaginal application of povidone-iodine containing medications . Am J Obstet Gynecol 1970;108:1175-1177. 8. Chabrolle JP, Rossier A: Goiter and hypothyroidism in the newborn after cutaneous absorption of iodine . Arch Dis Child 1978;53:495-498.Crossref 9. Higgins HP, Hawks GH, O'Sullivan M, et al: The effect of povidone-iodine on serum protein-bound iodine, when used as a surgical preparation on intact skin . Can Med Assoc J 1964;90:1298-1300. 10. Wolff J: Iodide goiter and the pharmacologic effects of excess iodine . Am J Med 1969;47:101-124.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1982

References

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