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Transient Hypoparathyroidism in an Infant of a Mother With a Renal Transplant

Transient Hypoparathyroidism in an Infant of a Mother With a Renal Transplant Abstract Since the first successful delivery of a viable infant from a mother who received a kidney transplant in 1958,1 there has been an increasing number of babies born to renal transplant recipients.2 Literature is accumulating regarding the special problems of the fetus and infant born to a parent having renal transplantation. These problems are most commonly related to compromised maternal renal status or immunosuppressive therapy necessary to ensure transplant viability. We report a case of transient hypoparathyroidism and tetany in an infant born to a mother who had a renal transplant. The mother was subsequently shown to have hyperparathyroidism. Report of a Case.—A 6-week-old girl was admitted to Good Samaritan Hospital with a two-week history of increasing irritability, jitteriness, and multifocal seizures. The infant was the product of a term pregnancy, complicated only by mild thirdtrimester vaginal spotting. The infant's mother was a 40-year-old gravida 3, para References 1. Murray JE, Reid DE, Harrison JH, et al: Successful pregnancies after human renal transplantation . N Engl J Med 269:341-343, 1963.Crossref 2. Barnes BA, Bergan JJ, Braun WE, et al: The 12th report of the human renal transplant registry . JAMA 233:787-796, 1975.Crossref 3. Wong ET, Lindall AW: Subcellular location of human parathyroid hormone immunoreactive peptides and preliminary evidence for a precursor to human PTH . Proc Soc Exp Biol Med 148:387-392, 1975. 4. Arnaud CD, Tsao HS, Littledike T: Radioimmunoassay of human parathyroid hormone in serum . J Clin Invest 50:21-34, 1971.Crossref 5. Ludwig GD: Hyperparathyroidism in relation to pregnancy . N Engl J Med 267:637-642, 1962.Crossref 6. Dorey LG, Gell JW: Primary hyperparathyroidism during the third trimester of pregnancy . Obstet Gynecol 45:469-472, 1975. 7. Delmonico FL, Neer RM, Cosimi AB, et al: Hyperparathyroidism during pregnancy . Am J Surg 131:328-337, 1976.Crossref 8. Hutchin P, Kessner DM: Diagnostic lead to hyperparathyroidism in the mother . Ann Intern Med 61:1109-1115, 1964.Crossref 9. David DS, Sakai S, Brennan BL, et al: Hypercalcemia after renal transplantation . N Engl J Med 289:398-401, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Transient Hypoparathyroidism in an Infant of a Mother With a Renal Transplant

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120300090023
Publisher site
See Article on Publisher Site

Abstract

Abstract Since the first successful delivery of a viable infant from a mother who received a kidney transplant in 1958,1 there has been an increasing number of babies born to renal transplant recipients.2 Literature is accumulating regarding the special problems of the fetus and infant born to a parent having renal transplantation. These problems are most commonly related to compromised maternal renal status or immunosuppressive therapy necessary to ensure transplant viability. We report a case of transient hypoparathyroidism and tetany in an infant born to a mother who had a renal transplant. The mother was subsequently shown to have hyperparathyroidism. Report of a Case.—A 6-week-old girl was admitted to Good Samaritan Hospital with a two-week history of increasing irritability, jitteriness, and multifocal seizures. The infant was the product of a term pregnancy, complicated only by mild thirdtrimester vaginal spotting. The infant's mother was a 40-year-old gravida 3, para References 1. Murray JE, Reid DE, Harrison JH, et al: Successful pregnancies after human renal transplantation . N Engl J Med 269:341-343, 1963.Crossref 2. Barnes BA, Bergan JJ, Braun WE, et al: The 12th report of the human renal transplant registry . JAMA 233:787-796, 1975.Crossref 3. Wong ET, Lindall AW: Subcellular location of human parathyroid hormone immunoreactive peptides and preliminary evidence for a precursor to human PTH . Proc Soc Exp Biol Med 148:387-392, 1975. 4. Arnaud CD, Tsao HS, Littledike T: Radioimmunoassay of human parathyroid hormone in serum . J Clin Invest 50:21-34, 1971.Crossref 5. Ludwig GD: Hyperparathyroidism in relation to pregnancy . N Engl J Med 267:637-642, 1962.Crossref 6. Dorey LG, Gell JW: Primary hyperparathyroidism during the third trimester of pregnancy . Obstet Gynecol 45:469-472, 1975. 7. Delmonico FL, Neer RM, Cosimi AB, et al: Hyperparathyroidism during pregnancy . Am J Surg 131:328-337, 1976.Crossref 8. Hutchin P, Kessner DM: Diagnostic lead to hyperparathyroidism in the mother . Ann Intern Med 61:1109-1115, 1964.Crossref 9. David DS, Sakai S, Brennan BL, et al: Hypercalcemia after renal transplantation . N Engl J Med 289:398-401, 1973.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1978

References