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Transfusion-Associated HIV Infection in a Neonate From a Seronegative Donor

Transfusion-Associated HIV Infection in a Neonate From a Seronegative Donor Abstract Sir.—In response to the recent editorial by Dr Hilgartner1 concerning acquired immunodeficiency syndrome (AIDS) in the transfused patient, we would like to relate an anecdotal experience that confirms the need for second-generation tests to improve the sensitivity and specificity of human immunodeficiency virus (HIV) antibody screening tests. Patient Report.—Monozygotic twin girls were born after a 31-week gestation to a mother with O-negative blood type and no risk factors for HIV infection. On day 26, twin B developed a bullous cellulitis of the right foot; a wound culture yielded Staphy-lococcus aureus. On day 45, her absolute neutrophil count was 0 and her platelets had fallen to 45×109/L (45 000/mm3). References 1. Hilgartner MW: AIDS in the transfused patient . AJDC 1987;141:194-198. 2. Ammann AJ, Wara DW, Dritz S, et al: Acquired immunodeficiency in an infant: Possible transmission by means of blood products . Lancet 1983;1:956-958.Crossref 3. Saulsbury FT, Boyle RJ, Wykoff RF, et al: Thrombocytopenia as the presenting manifestation of a human T-lymphotropic virus type III infection in infants . J Pediatr 1986;109:30-34.Crossref 4. Transfusion-associated human T-lymphotropic virus type III/lymphadenopathy-associated virus infection from a seronegative donor—Colorado . MMWR 1986;35:389-391. 5. Ward JW, Grindon AJ, Feorino PM, et al: Laboratory and epidemiologic evaluation of an enzyme immunoassay for antibodies to HTLV-III . JAMA 1986;256:357-361.Crossref 6. Salahuddin SZ, Groopman JE, Markham PD, et al: HTLV-III in symptom-free seronegative persons . Lancet 1984;2:1418-1420.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Transfusion-Associated HIV Infection in a Neonate From a Seronegative Donor

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460110015001
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—In response to the recent editorial by Dr Hilgartner1 concerning acquired immunodeficiency syndrome (AIDS) in the transfused patient, we would like to relate an anecdotal experience that confirms the need for second-generation tests to improve the sensitivity and specificity of human immunodeficiency virus (HIV) antibody screening tests. Patient Report.—Monozygotic twin girls were born after a 31-week gestation to a mother with O-negative blood type and no risk factors for HIV infection. On day 26, twin B developed a bullous cellulitis of the right foot; a wound culture yielded Staphy-lococcus aureus. On day 45, her absolute neutrophil count was 0 and her platelets had fallen to 45×109/L (45 000/mm3). References 1. Hilgartner MW: AIDS in the transfused patient . AJDC 1987;141:194-198. 2. Ammann AJ, Wara DW, Dritz S, et al: Acquired immunodeficiency in an infant: Possible transmission by means of blood products . Lancet 1983;1:956-958.Crossref 3. Saulsbury FT, Boyle RJ, Wykoff RF, et al: Thrombocytopenia as the presenting manifestation of a human T-lymphotropic virus type III infection in infants . J Pediatr 1986;109:30-34.Crossref 4. Transfusion-associated human T-lymphotropic virus type III/lymphadenopathy-associated virus infection from a seronegative donor—Colorado . MMWR 1986;35:389-391. 5. Ward JW, Grindon AJ, Feorino PM, et al: Laboratory and epidemiologic evaluation of an enzyme immunoassay for antibodies to HTLV-III . JAMA 1986;256:357-361.Crossref 6. Salahuddin SZ, Groopman JE, Markham PD, et al: HTLV-III in symptom-free seronegative persons . Lancet 1984;2:1418-1420.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1987

References