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Transferrin Receptor Expression by Retinal Pigment Epithelial Cells in Proliferative Vitreoretinopathy

Transferrin Receptor Expression by Retinal Pigment Epithelial Cells in Proliferative... Abstract To the Editor. —We were interested in the study by Jaffe and associates,1 disclosing the potential use of immunotoxins to inhibit the growth of retinal pigment epithelial cells in patients with proliferative vitreoretinopathy (PVR). Exposing the proliferating retinal pigment epithelial cells to an immunotoxin composed of a monoclonal antibody directed against transferrin receptor and conjugated to ricin A chain, caused a significant decrease in the number of cells and affected their morphologic appearance. This study was based on the hypothesis that transferrin receptors, which are expressed at high density on various types of proliferating cells, could constitute a useful target for immunotoxins, whereby proliferating retinal pigment epithelial cells would be inhibited during PVR.This hypothesis, however, was investigated by studying the cells in vitro, not in vivo, so that it could be determined whether such antiproliferative agents might be used in patients with PVR. We have been studying PVR References 1. Jaffe GJ, Earnest K, Fulcher S, Lui GM, Houston LL. Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells . Arch Ophthalmol . 1990;108:1163-1168.Crossref 2. Baudouin C, Fredj-Reygrobellet D, Baudouin F, Lapalus P, Gastaud P. Immunopathological study on proliferative vitreoretinopathy . Am J Ophthalmol . 1989;108:387-394. 3. Baudouin C, Fredj-Reygrobellet D, Gordon WC, et al. Immunohistologic study of epiretinal membranes in proliferative vitreoretinopathy . Am J Ophthalmol . 1990;110:593-598. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Transferrin Receptor Expression by Retinal Pigment Epithelial Cells in Proliferative Vitreoretinopathy

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1991.01080090017007
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We were interested in the study by Jaffe and associates,1 disclosing the potential use of immunotoxins to inhibit the growth of retinal pigment epithelial cells in patients with proliferative vitreoretinopathy (PVR). Exposing the proliferating retinal pigment epithelial cells to an immunotoxin composed of a monoclonal antibody directed against transferrin receptor and conjugated to ricin A chain, caused a significant decrease in the number of cells and affected their morphologic appearance. This study was based on the hypothesis that transferrin receptors, which are expressed at high density on various types of proliferating cells, could constitute a useful target for immunotoxins, whereby proliferating retinal pigment epithelial cells would be inhibited during PVR.This hypothesis, however, was investigated by studying the cells in vitro, not in vivo, so that it could be determined whether such antiproliferative agents might be used in patients with PVR. We have been studying PVR References 1. Jaffe GJ, Earnest K, Fulcher S, Lui GM, Houston LL. Antitransferrin receptor immunotoxin inhibits proliferating human retinal pigment epithelial cells . Arch Ophthalmol . 1990;108:1163-1168.Crossref 2. Baudouin C, Fredj-Reygrobellet D, Baudouin F, Lapalus P, Gastaud P. Immunopathological study on proliferative vitreoretinopathy . Am J Ophthalmol . 1989;108:387-394. 3. Baudouin C, Fredj-Reygrobellet D, Gordon WC, et al. Immunohistologic study of epiretinal membranes in proliferative vitreoretinopathy . Am J Ophthalmol . 1990;110:593-598.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1991

References

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